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| Code | CSB-PA03774D0Rb |
| Size | US$299 |
| Uniprot No. | P54725 |
| Protocols | ELISA Protocol |
| Immunogen | Recombinant Human UV excision repair protein RAD23 homolog A protein (2-201AA) |
| Raised in | Rabbit |
| Species Reactivity | Human |
| Tested Applications | ELISA |
| Relevance | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. |
| Form | Liquid |
| Conjugate | Biotin |
| Storage Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method | >95%, Protein G purified |
| Isotype | IgG |
| Clonality | Polyclonal |
| Alias | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A), RAD23A |
| Immunogen Species | Human |
| Research Area | Epigenetics and Nuclear Signaling |
| Target Names | RAD23A |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
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| Function | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; FUNCTION |
| Subcellular Location | Nucleus |
| Protein Families | RAD23 family |
| Database Links |
HGNC: 9812 OMIM: 600061 KEGG: hsa:5886 STRING: 9606.ENSP00000467024 UniGene: Hs.643267 |
| Pathway | Protein processing in endoplasmic reticulum |
RAD23A Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA03774A0Rb | RAD23A Antibody | Human | ELISA, WB, IHC |
| CSB-PA03774B0Rb | RAD23A Antibody, HRP conjugated | Human | ELISA |
| CSB-PA03774C0Rb | RAD23A Antibody, FITC conjugated | Human | ELISA |
RAD23A Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA019259GA01HU | RAD23A Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA040140 | RAD23A Antibody | Human,Mouse | WB,IF,ELISA |
RAD23A Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-EP019259HU | Recombinant Human UV excision repair protein RAD23 homolog A(RAD23A) | E.coli |
| CSB-YP019259HU | Recombinant Human UV excision repair protein RAD23 homolog A(RAD23A) | Yeast |
| CSB-BP019259HU CSB-MP019259HU |
Recombinant Human UV excision repair protein RAD23 homolog A(RAD23A) | Baculovirus Mammalian cell |
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