RAMP1 Antibody

Datasheet
Code CSB-PA019304GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. O60894
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunogen Human RAMP1
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,WB
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity Purified
Isotype IgG
Alias receptor (G protein-coupled) activity modifying protein 1;
Immunogen Species Homo sapiens (Human)
Target Names RAMP1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This protein is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
HGNC 9843
RGD 61870
MGI 1858418
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Function Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families RAMP family
Tissue Specificity Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.
Database Links

HGNC: 9843

OMIM: 605153

KEGG: hsa:10267

STRING: 9606.ENSP00000254661

UniGene: Hs.471783

Pathway Vascular smooth muscle contraction

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