RPS6 Antibody

Code CSB-PA020463LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA020463LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA020463LA01HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA020463LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RPS6 Polyclonal antibody
Uniprot No.
Target Names
RPS6
Alternative Names
40S ribosomal protein S6 antibody; Air8 antibody; NP33 antibody; Phosphoprotein NP33 antibody; Pp30 antibody; Ribosomal protein S6 antibody; RP S6 antibody; rps6 antibody; RS6 antibody; RS6_HUMAN antibody; S6 antibody; S6 Ribosomal Protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 40S ribosomal protein S6 protein (35-229AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RPS6 Antibody (Product code: CSB-PA020463LA01HU) is Non-conjugated. For RPS6 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA020463LB01HU RPS6 Antibody, HRP conjugated ELISA
FITC CSB-PA020463LC01HU RPS6 Antibody, FITC conjugated
Biotin CSB-PA020463LD01HU RPS6 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA.
Gene References into Functions
  1. JMJD5 catalyzes stereoselective C-3 hydroxylation of arginine residues in sequences from human RCCD1 and ribosomal protein S6. PMID: 29563586
  2. single 60-min bout of peristaltic pulse external pneumatic compression transiently upregulates phosphorylated ribosomal protein s6 and the Akt-mTOR signalling cascade. PMID: 26769680
  3. MiR-129-5p sensitized Her-2-positive breast cancer to trastuzumab by downregulating rpS6. PMID: 29258115
  4. Dual PI3K/mTOR inhibition represents an effective therapeutic strategy in uterine leiomyosarcoma, and p-S6(S240) expression is a potential predictive biomarker for response to treatment. PMID: 28232476
  5. this study unveils an unprecedented correlation of mTOR activation with improved clinical outcome in patients with laryngeal carcinomas and uncovers the potential of p-S6 expression as a good prognostic biomarker and an inverse predictor of lymph node and distant metastases. PMID: 27119232
  6. the aggregation of rpS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase. PMID: 26639987
  7. Study examined baseline levels of S6 phosphorylated at Ser235/236 (pS6Ser235/236) or Ser240/244 (pS6Ser240/244)and a possible effect of tau pathology. Findings argue against the idea that high levels of pS6Ser235/236 in neurons are a consequence of a higher expression of S6 protein and speak for an increased phosphorylation of S6 in intensely pS6Ser235/236-labeled neurons. PMID: 28119058
  8. Data suggest ribosomal protein S6 (rpS6) as tumor marker for renal cell carcinoma. PMID: 26506236
  9. Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer PMID: 26490682
  10. p-rpS6 is a robust post-treatment indicator of HER2 pathway-targeted therapy resistance PMID: 26329528
  11. Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation. PMID: 25379021
  12. Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway. PMID: 25659153
  13. The expression levels of phospho-mTOR and phospho-S6RP may be potential predictive biomarkers for efficacy of everolimus in patients with metastatic renal cell carcinoma. PMID: 24886512
  14. we report that phosphorylation of ribosomal protein S6 is greatly increased in BRCA1 deficient cells resistant to PARP inhibition PMID: 24831086
  15. Suggest phosphorylated S6 as an immunohistochemical biomarker of vulvar intraepithelial neoplasia. PMID: 23765247
  16. Suggest that p-S6 and the ratio of p-S6/S6 are closely relevant to tumor progression and have prognostic significance in esophageal squamous cell carcinoma. PMID: 22996377
  17. S6 phosphorylation at S240/4 is strongly cell cycle-regulated. PMID: 23255058
  18. High Ribosomal Protein S6 is associated with renal cell carcinoma metastases. PMID: 21792700
  19. a novel mechanism for modulating the RPS6 function by PP1 and ATM which regulates cell growth and survival in response to DNA-damage stim PMID: 22451389
  20. Nearly 20-fold more neurons contain pS6-positive granules in Alzheimer's disease hippocampus compared to age-matched controls. PMID: 21968813
  21. Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6. PMID: 21765940
  22. Here, the authors show that ribosomal protein S6 (RPS6) interacts with LANA. PMID: 21734034
  23. The mTOR/S6 signal pathway is activated in refractory/relapsed aplastic anemia, and can be suppressed by rapamycin or CTLA-4Ig. PMID: 19954658
  24. RPS6 associates with multiple mRNAs containing a 5' terminal oligopyrimidine tract. These findings expand our understanding of the mechanism(s) involved in ribosomal biogenesis and deregulated protein synthesis in diffuse large B-cell lymphoma (DLBCL). PMID: 21102526
  25. S240/244-phosphorylated S6 is predominantly nuclear but detectable in the cytoplasm, whereas S235/236-phosphorylated S6 is exclusively localized to the nucleus. PMID: 20625781
  26. Regulation of ribosomal protein S6 phosphorylation by casein kinase 1 and protein phosphatase 1. PMID: 21233202
  27. Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. PMID: 21147110
  28. Data show that the mTOR effectors, 4EBP1, p70S6K and rpS6, are highly activated in cultured and primary FLT3-mutated acute myeloid leukemia (AML) cells. PMID: 21067588
  29. when exercise is performed in a fasted state, the increase in phosphorylation of signalling molecules such as p70(S6k) and the S6 ribosomal protein in human muscle depends on the exercise volume PMID: 20617335
  30. Genetic alterations of TP53 and RPS6 were different in different areas of the same oral squamous cell carcinoma tumor. PMID: 17565818
  31. Rheb is a mediator of RPS6. PMID: 12820960
  32. IFNgamma-activated p70 S6 kinase phosphorylates the 40S S6 ribosomal protein on serines 235/236, to regulate IFNgamma-dependent mRNA translation. PMID: 15051500
  33. Cortical tuber giant cells in a case of epileptogenic tuberous sclerosis showed predominantly nuclear hamartin, cytosolic tuberin, and hyperphosphorylation of S6. PMID: 15477556
  34. the phosphorylation of Tyr(1077) on LepRb during receptor activation, substantiate the hypothalamic regulation of STAT5 and S6 by leptin, and define the alternate LepRb signaling pathways PMID: 17726024
  35. Structure, localization and molecular assembly in vitro and in vivo of a human rpS6, were examined using antibodies (Abs) prepared by immunizing rabbits with synthetic peptides. PMID: 18039684
  36. The level of phosphorylated S6 ribosomal protein expression was predictive of early tumor response to the mammalian target of rapamycin (mTOR)inhibitor, suggesting that this is a promising new predictive sarcoma marker for targeted mTOR inhibitor therapy PMID: 18157089
  37. The results demonstrate that multiple muscarinic receptor subtypes regulate mTOR, and that both MAPK-dependent and -independent mechanisms may mediate the response in a cell context-specific manner. PMID: 18348264
  38. rpS6, especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis PMID: 18362888
  39. Resistance exercise decreases eIF2Bepsilon phosphorylation and potentiates the feeding-induced stimulation of p70S6K1 and rpS6 in young men. PMID: 18565837
  40. Basophilic inclusions from patients with adult-onset atypical motor neuron disease were distinctly labeled with the antibodies against poly(A)-binding protein 1, T cell intracellular antigen 1, and ribosomal protein S6. PMID: 18642007

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Protein Families
Eukaryotic ribosomal protein eS6 family
Database Links

HGNC: 10429

OMIM: 180460

KEGG: hsa:6194

STRING: 9606.ENSP00000369757

UniGene: Hs.408073

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