S100A3 Antibody

Code CSB-PA040284
Size US$100
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Product Details

Uniprot No.
Target Names
S100A3
Alternative Names
Protein S 100E antibody; Protein S-100E antibody; Protein S100 A3 antibody; Protein S100-A3 antibody; S100 calcium binding protein A3 antibody; S100 calcium-binding protein A3 antibody; S100a3 antibody; S100E antibody; S10A3_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human S-100A3.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
IHC, ELISA
Recommended Dilution
Application Recommended Dilution
IHC 1:100-1:300
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation.
Gene References into Functions
  1. S100A3 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  2. One disulfide bridge is between Cys30 in the N-terminal pseudo-EF-hand and Cys68 in the C-terminal EF-hand (SS1), and another disulfide bridge attaches Cys99 in the C-terminal coil structure to Cys81 in helix IV (SS2). PMID: 21377473
  3. crystal structure of S100A3 at 1.7-A resolution PMID: 12045193
  4. structure was solved by MIRAS phasing PMID: 12136135
  5. Purification and characterization of the S100A3 protein from human hair cuticles. PMID: 12470658
  6. cytoplasmic S100A3 within the cuticular layer is mostly co-localized with the type III isoform of peptidylarginine deiminase (PAD3) PMID: 18083705

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Subcellular Location
Cytoplasm.
Protein Families
S-100 family
Tissue Specificity
Skin specific, specifically expressed at the inner endocuticle of hair fibers.
Database Links

HGNC: 10493

OMIM: 176992

KEGG: hsa:6274

STRING: 9606.ENSP00000357701

UniGene: Hs.557609

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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