S1PR1 Antibody

Code CSB-PA020650GA01HU
Size US$685
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Product Details

Uniprot No. P21453
Target Names S1PR1
Alternative Names CD363 antibody; CHEDG 1 antibody; CHEDG1 antibody; D1S3362 antibody; ECGF 1 antibody; ECGF1 antibody; EDG 1 antibody; EDG1 antibody; endothelial differentiation G protein coupled receptor 1 antibody; Endothelial differentiation G-protein coupled receptor 1 antibody; Endothelial differentiation sphingolipid G protein coupled receptor 1 antibody; FLJ58121 antibody; G protein coupled sphingolipid receptor antibody; g protein-coupled receptor edg-1 antibody; S1P receptor 1 antibody; S1P receptor Edg 1 antibody; S1P receptor Edg-1 antibody; S1P receptor Edg1 antibody; S1P(1) receptor antibody; S1P1 antibody; s1pr1 antibody; S1PR1_HUMAN antibody; sphingolipid g-protein-coupled receptor 1 antibody; Sphingosine 1 phosphate receptor Edg 1 antibody; Sphingosine 1 phosphate receptor EDG1 antibody; sphingosine 1- phosphate receptor 1 antibody; Sphingosine 1-phosphate receptor 1 antibody; Sphingosine 1-phosphate receptor Edg-1 antibody; Sphingosine 1phosphate receptor type 1 S1P1 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Human S1PR1
Immunogen Species Homo sapiens (Human)
Isotype IgG
Purification Method Antigen Affinity purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer 0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications ELISA,WB
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Gene References into Functions
  1. Overexpression of S1PR1 promoted subcutaneous xenograft growth and pulmonary metastases and enhanced expression of epithelial-to-mesenchymal transition markers. PMID: 30453284
  2. Knockdown of BATF3 in HL cell lines revealed that BATF3 contributed to the transcriptional programme of primary HRS cells, including the upregulation of S1PR1. PMID: 28878352
  3. Data suggest that sphingosine-1-phosphate receptor 1 (S1P1) exhibits a inhibitory effect on kidney ischemia/reperfusion injury-inducedepithelial to mesenchymal transition (EMT) in the kidney by affecting the PI3K/Akt pathway. PMID: 29901713
  4. Extracellular alpha-synuclein induces sphingosine S1P1R uncoupled from inhibitory G-protein leaving beta-arrestin signal intact. PMID: 28300069
  5. These results demonstrated that ApoM protein mass were clearly higher in the NSCLC tissues than in non-small cell lung cancer (NSCLC) tissues. Overexpression of ApoM could promote NSCLC cell proliferation and invasion in vitro and tumor growth in vivo, which might be via upregulating S1PR1 and activating the ERK1/2 and PI3K/AKT signaling pathways. PMID: 29750961
  6. We conclude that S1P attenuates the invasion of C643 cells by activating S1P2 and the Rho-ROCK pathway, by decreasing calpain activity, and by decreasing the expression, secretion and activity of MMP2 and, to a lesser extent, MMP9. Our results thus unveil a novel function for the S1P2 receptor in attenuating thyroid cancer cell invasion. PMID: 29734379
  7. Elevated S1PR1 expression and STAT3 activation are also observed in human NB cells with acquired resistance to etoposide. We show in vitro and in human NB xenograft models that treatment with FTY720, an FDA-approved drug and antagonist of S1PR1, dramatically sensitizes drug-resistant cells to etoposide. PMID: 28716816
  8. this review discusses sphingosine-1-phosphate receptor as a novel therapeutic target in ulcerative colitis PMID: 27494562
  9. Astrocytic S1PR controls astrocyte neurotoxicity and monocyte recruitment and activation. PMID: 28167760
  10. High S1PR1 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis. PMID: 28206609
  11. Low S1PR1 expression is associated with Coxsackievirus B3-induced myocarditis. PMID: 28986246
  12. These findings are consistent with a model in which signalling via S1P and S1PR1 are integral components in the response of lymphatic endothelial cells to the stimulus provided by fluid flow. PMID: 27974574
  13. S1PR1/3 silencing alters proliferation, adhesion, viability and lateral motility in estrogen receptor-negative MCF-7 and estrogen receptor-positive MDA-MB-231 breast cancer cells. PMID: 28982858
  14. Activated S1PR1 signaling regulates the production of cellular adhesion molecules by inhibiting NF- kappaB activation via a beta-arrestin2-dependent manner PMID: 28399143
  15. Model recombinant HDL (rHDL) particles formed in vitro with S1P incorporated into the particle initiated the internalization of S1PR1, whereas rHDL without supplemented S1P did not, suggesting that S1P transported in HDL can selectively activate S1PR1. PMID: 27881715
  16. Blocking of S1PR activity and inhibition of S1P synthesis led to decreased expression of fibrosis and tissue remodeling-related proteins in primary cultures of orbital fibroblasts derived from patients with GO. PMID: 28492873
  17. a lipid molecule repeatedly entered the receptor between the extracellular ends of TM1 and TM7, providing important insights into the pathway of ligand entry into the S1PR1 . PMID: 28370663
  18. Mature human thymocytes rely on S1P-R1 to migrate toward S1P. Taken in the context of murine work demonstrating that S1P is required for thymocyte egress to the periphery. PMID: 27056271
  19. ApoM-bound sphingosine-1-phosphate regulates adhesion molecule abundance, leukocyte-endothelial adhesion, and endothelial barrier function via sphingosine-1-phosphate receptor1. PMID: 27879252
  20. The S1P1,3 activation results in Akt phosphorylation and subsequent activation of eNOS via phosphorylation at serine(1177) and dephosphorylation at threonine(495). PMID: 27282481
  21. HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 and S1P3 receptors on vascular endothelium. PMID: 28179022
  22. The present high prevalence of S1PR1 overexpression warrants the consideration of testicular diffuse large B-cell lymphoma as a distinct disease subtype and suggests the potential of the S1P/S1PR1 axis as a therapeutic target. PMID: 27061580
  23. S1PR1 inhibits the apoptosis of human myeloid leukemia cells and promotes their proliferation. PMID: 27572094
  24. These results suggest that S1P signaling plays a role in cell proliferation and drug resistance in multiple myeloma, and targeting this pathway will provide a new therapeutic direction for multiple myelomamanagement. PMID: 27785703
  25. Sphingosine 1-phosphate-induced IL-8 gene expression is mainly regulated via S1PR(1), and its secretion is regulated through S1PR(2) receptor subtype. PMID: 26321412
  26. multiple lines of evidence demonstrate that S1PR1 signaling sets the sensitivity of pDC amplification of IFN responses, thereby blunting pathogenic immune responses PMID: 26787880
  27. The results indicate that sphingosine 1-phosphate is involved in the migration of precursor T-cell lymphoblastic leukemia-lymphoma blasts in vitro, which is dependent on S1P1 expression. PMID: 26824863
  28. Overexpression of miR148a or inhibition of S1PR1 suppressed SKOV3 cell migration and invasion, while restoration of S1PR1 expression reversed the suppressive effect of miR148a upregulation on SKOV3 cell migration and invasion. PMID: 26004261
  29. the ability of ApoM(+)HDL to act as a biased agonist on S1P1 inhibits vascular inflammation, which may partially explain the cardiovascular protective functions of HDL. PMID: 26268607
  30. S1P receptor modulation reduces leukocyte migration across the endothelial barrier PMID: 26197437
  31. SGPL1 ratio correlated with increased cellular sphingosine-1-phosphate (S1P), and S1P correlated with drug resistance (IC50). PMID: 26493335
  32. The role of sphingosine-1-phosphate in the production of immature double-negative thymocytes in experimental and chronic Chagas disease is reported. PMID: 25330249
  33. Within lymphoid follicles, the S1P1 distribution pattern is complementary to that of CCR7/CXCR4, with strong immunoreactivity tightly restricted to mantle zone B cells. This may play a role in B-cell migration toward the S1p-enriched follicle center. PMID: 26282174
  34. Ponesimod, a selective S1P1 receptor modulator, causes small, dose-dependent QT prolongation. PMID: 25287214
  35. rapid reduction of endothelial cell surface expression of S1PR1 subsequent to Y143 phosphorylation is a crucial mechanism of modulating S1PR1 signaling, and hence the endothelial barrier repair function of S1P. PMID: 25588843
  36. Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. PMID: 25188412
  37. both S1PR1 and S1PR2 play a pivotal role in hyperglycemia-induced EC dysfunction and endothelial injury by reducing and enhancing the production of oxidative stress. PMID: 25673082
  38. S1PR1 expression was associated with unfavourable clinicopathological features and the expression of several anti-apoptosis/proliferation-related markers in urothelial carcinoma. PMID: 26238015
  39. Data suggest an SNP in S1PR1 (rs41287280) is associated with protection against coronary artery disease; some SNPs in S1PR1 have the effect that endocytosis is resistant to S1PR1 antagonists (fingolimod) or S1PR1 agonists (sphingosine 1-phosphate). PMID: 25293589
  40. Activation of the S1PR1-PLC-IP3 R-Ca(2+) -Rac1 pathway governs the low-dose S1P-enhanced endothelial barrier integrity. PMID: 25557733
  41. S1P interacts with its receptors on neutrophils, resulting in NADPH oxidase activation by the PI3K-Akt cell signaling pathway and induction of the neutrophil respiratory burst. PMID: 25872153
  42. S1P1 is widely expressed across tissues and, when activated, has broad functions in the immune, vascular and nervous systems. [Review] PMID: 25498971
  43. Our data demonstrate that neuronal cell death evoked by ceramide is regulated by PARP/PAR/AIF and by S1P receptor signalling. PMID: 24420784
  44. Expression of functional S1PR1 is reduced by B cell receptor signaling and increased by inhibition of PIK3CD but not SYK or BTK in chronic lymphocytic leukemia cells. PMID: 25632006
  45. The data demonstrates that S1P1 expression is differentially modulated in grey matter and white matter lesions in multiple sclerosis. PMID: 23551178
  46. S1PR1 was a target of miR-125b-1-3p in the placenta. Overexpression of S1PR1 could reverse the inhibitory effect of miR-125b-1-3p on the invasion of trophoblast cells. Abnormal expression of miR-125b-1-3p might contribute to the etiology of preeclampsia. PMID: 25251470
  47. Study demonstrates a stark contrast between the consequences of S1PR1 signaling in Treg cells in the periphery versus tumors. PMID: 24630990
  48. Aberrant S1PR1 expression in colorectal cancer was associated with metachronous liver metastasis and worse survival outcome PMID: 24972972
  49. Data show that sphingosine kinase SphK1 and sphingosine-1-phosphate (S1P) receptors S1P1, S1P2, S1P3, and S1P5 were expressed from primary, up to recurrent and secondary glioblastomas, with sphingosine kinase SphK2 levels were highest in primary tumors. PMID: 24903384
  50. study demonstrates loss of S1P and sphingosine kinase activity early in AD pathogenesis, and prior to AD diagnosis. Our findings establish a rationale for further exploring S1P receptor pharmacology in the context of AD therapy. PMID: 24456642
  51. Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis. PMID: 24679343
  52. the regulated expression of S1PR1 might modulate the egress of the leukemic clone from lymphoid tissues to peripheral blood. PMID: 25127862
  53. miR-363 is a negative regulator of S1PR1 expression in hepatocellular carcinoma cells. PMID: 24631531
  54. Edg-1 is a potential target gene of RTEF-1 and is involved in RTEF-1-induced angiogenesis in endothelial cells. PMID: 24520353
  55. Data indicate that the internalization of S1P1 receptor was induced by Syl930-P, the active phosphorylated form of selective S1P1 receptor agonist Syl930. PMID: 24780445
  56. we provide evidences that S1PR1/3, but not S1PR2, negatively regulate the expression of collagen in hMSCs using cellular and molecular approaches in vitro PMID: 24038457
  57. Three-dimensional structure of the S1P1 receptor has been determined by X-ray crystallography and the specifics of the sphingosine 1 phosphate ligand binding pocket mapped. [review] PMID: 24728592
  58. pro-survival/anti-apoptotic signalling from S1P1 is intimately linked to its ability to promote the accumulation of pro-survival protein Mcl-1 and downregulation of pro-apoptotic BH3-only protein Bim via distinct signalling pathways. PMID: 24263101
  59. S1PR1 expression on macrophages might, therefore, be relevant for restoring tissue homeostasis during the resolution of inflammation. PMID: 23934754
  60. binding of sphingosine-1-phosphate to sphingosine-1-phosphate receptor 2 activates multiple Rho GTPases-dependent pathways that coordinate with PI3K pathway for secretion of IL-6 in BeWo cells. PMID: 23538947
  61. The role of protein kinase C (PKC) isozymes in phorbol myristate acetate (PMA)-induced sphingosine 1-phosphate (S1P) receptor 1 (S1P1) phosphorylation was studied. PMID: 24239722
  62. Data indicate that in cultured endothelial cell (umbilical vein endothelial cells) showed a co-localization of sphingosine-1-phosphate receptor S1P(1) and proteinase activated receptor-2 PAR2. PMID: 24131465
  63. key role of Sphk1, S1PR1 and S1PR3 in angiogenesis underlying the liver fibrosis process PMID: 23466305
  64. Impaired S1P1 phosphorylation enhances TH17 polarization and exacerbates autoimmune neuroinflammation. PMID: 24076635
  65. S1P1 overexpression or ERp29 absence is related to the carcinogenesis and progression, and may be potential biomarkers for early detection of gallbladder adenocarcinoma. PMID: 23558074
  66. subset of classical Hodgkin lymphoma cases (7/57; 12%) shows strong, membranous staining for S1PR1 in Hodgkin-Reed-Sternberg cells PMID: 23419711
  67. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways PMID: 23300082
  68. PI3K-C2alpha plays the crucial role in S1P(1) internalization into the intracellular vesicular compartment, Rac1 activation on endosomes, and thereby migration through regulating vesicular trafficking in ECs PMID: 23192342
  69. S1PR1 and ITGB4 transactivation are rate-limiting events in the transduction of HGF signals via a dynamic c-Met complex resulting in enhanced EC barrier integrity PMID: 23212923
  70. cell surface levels of S1P1 and levels of S1P1 in caveolin-enriched microdomains were higher after treatment with HDL-S1P as compared with albumin-S1P. PMID: 23135269
  71. S1P1 expression is controlled by the pro-oxidant activity of p66Shc and is impaired in B-CLL patients with unfavorable prognosis. PMID: 23033271
  72. S1P receptors S1P1,2,3 are expressed in human anaplastic thyroid cancer C643 and THJ-16T cells at both mRNA and protein levels PMID: 22889737
  73. Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes. PMID: 22898216
  74. The S1PR1 signaling inhibits angiogenic sprouting and enhances cell-to-cell adhesion. PMID: 22975327
  75. However, growing evidence strongly suggests that the assessment of Sphingosine-1-phosphate receptor 1/3 (S1P1/3) own advantages over present measurements in predicting the risk of developing diabetic cardiovascular diseases. PMID: 22595806
  76. Report role for S1PR1 in regulation venous endothelial barrier function. PMID: 22837470
  77. Persistent activated STAT3 colocalizes with elevated expression of S1PR1, a G-protein-coupled receptor for sphingosine-1-phosphate (S1P), in the tumor cells of the activated B cell-like subtype of diffuse large B-cell lymphoma. PMID: 22745305
  78. abdominal aortic aneurysms have down-regulation of the S1P2 protein with simultaneous up-regulation of the S1P3 protein, but not S1P1 PMID: 22547907
  79. the structure of S1P highlighted key interactions associated with the binding of S1P and agonists and suggested that the ligand may gain access to the binding pocket by lateral diffusion within the plasma membrane. PMID: 22623751
  80. Data suggest that S1PR1 transactivation is dependent on sphingosine kinase 1, is upstream of MAP kinase signaling system, and is required for LDL-regulated expression of connective tissue growth factor in mesangial cells. PMID: 22422617
  81. analysis of quinolinone-based agonists of S1P PMID: 22104144
  82. 5- and 6-subtituted benzothiazoles with improved physicochemical properties are potent S1P agonists with in vivo lymphocyte-depleting activity PMID: 22100314
  83. Demonstrate that S1PR1-STAT3 signalling enables myeloid cells to intravasate, prime the distant organ microenvironment and mediate sustained proliferation and survival of their own and other stromal cells at future metastatic sites. PMID: 22624714
  84. the first report to link the two signaling events that control migration through the lymph nodes: CCR7 mediates entry into the lymph nodes and EDG-1 signaling controls their subsequent exit. PMID: 22334704
  85. These findings suggest that S1P/S1P1 signaling may play an important role in RANKL expression by MH7A cells and CD4(+) T cells. PMID: 22326262
  86. Purification and identification of activating enzymes of CS-0777, a selective sphingosine 1-phosphate receptor 1 modulator, in erythrocytes. PMID: 21613209
  87. FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2 PMID: 21719706
  88. Mobilization with rhG-CSF obviously down-regulates the expression of S1P1 in CD4+ T cells. PMID: 20416181
  89. SphK/S1P/S1PRs signaling axis plays an important role in liver fibrosis and is involved in the directed migration of hepatic myofibroblasts into the damaged areas. PMID: 21145832
  90. These data have identified an additional function regulated by S1P/S1PR1,3 axis involving migration and fibrogenic activation of hepatic stellate cells. PMID: 21660960
  91. The activation of S1PR results in increased chemotactic response of CD34(+) hematopoietic stem cells to SDF-1. PMID: 19778812
  92. These results support a model in which the interaction between sphingosine kinase 1, sphingosine 1-phosphate receptors 1 and/or 3, and ERK-1/2 might drive breast cancer progression PMID: 20889557
  93. Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1, and ICAM1 in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia. PMID: 20951945
  94. this study demonstrated that reactive astrocytes in MS lesions and cultured under proinflammatory conditions strongly enhance expression of S1P receptors 1 and 3. PMID: 20648639
  95. strong support for a role for S1PR1 gene variants in asthma susceptibility and severity. PMID: 20624651
  96. In four-and-a-half LIM domain protein (FHL)2-deficient bone marrow-derived dendritic cells (BMDC), repression of S1PR1 is lost, leading to its overexpression. Signaling via S1PR1 is responsible for increased migratory phenotype of FHL2-deficient BMDCs. PMID: 20592280
  97. S1PR1 is localized in astrocytes, and its expression level may change during the processes that occur after brain damage. PMID: 20566754
  98. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor1. PMID: 20348395
  99. Data hypothesize that VEGFR-2 forms a signaling complex with S1P(1) and and protein kinase C-alpha , evoking bidirectional signaling regulating both ERK1/2 phosphorylation and haptotaxis of ML-1 cells. PMID: 20501673
  100. Sphingosine-1-phosphate receptor 1 immunohistochemistry may be useful in the histological diagnosis of mantle cell lymphoma with formalin-fixed and paraffin-embedded sections. PMID: 20081804

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Subcellular Location Cell membrane, Multi-pass membrane protein, Endosome, Membrane raft
Protein Families G-protein coupled receptor 1 family
Tissue Specificity Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.
Database Links

HGNC: 3165

OMIM: 601974

KEGG: hsa:1901

STRING: 9606.ENSP00000305416

UniGene: Hs.154210

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