Code | CSB-PA020650GA01HU |
Size | US$685 |
Uniprot No. | P21453 |
Target Names | S1PR1 |
Alternative Names | sphingosine-1-phosphate receptor 1;S1PR1;CHEDG1;D1S3362;ECGF1;EDG-1;EDG1;FLJ58121;S1P1 ; |
Raised in | Rabbit |
Species Reactivity | Human,Mouse,Rat |
Immunogen | Human S1PR1 |
Immunogen Species | Homo sapiens (Human) |
Isotype | IgG |
Purification Method | Antigen Affinity purified |
Concentration | It differs from different batches. Please contact us to confirm it. |
Buffer | 0.1M NaHCO3,0.1M Glycine, 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
Tested Applications | ELISA,WB |
Protocols | ELISA Protocol Western Blotting(WB) Protocol |
Troubleshooting and FAQs | Antibody FAQs |
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
Still Have Questions? | Leave a Message or Start an on-line Chat |
Function | G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. |
Subcellular Location | Cell membrane, Multi-pass membrane protein, Endosome, Membrane raft |
Protein Families | G-protein coupled receptor 1 family |
Tissue Specificity | Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. |
Database Links |
HGNC: 3165 OMIM: 601974 KEGG: hsa:1901 STRING: 9606.ENSP00000305416 UniGene: Hs.154210 |
2-hydroxyisobutyryl-HIST1H1C (K116) Antibody
Applications: ELISA, ICC, IF, ChIP
Species Reactivity: Human
Tel: 301-363-4651
Email: support@cusabio.com
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