SEC61G Antibody

Code CSB-PA020959GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SEC61G
Alternative Names
SEC61G; Protein transport protein Sec61 subunit gamma
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SEC61G
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER.
Gene References into Functions
  1. Sequencing of childhood ependymoma samples indicate Sec61 gamma subunit protein (SEC61G)-epidermal growth factor receptor (EGFR) chimeric mRNAs in one infratentorial ependymoma , arguing that this fusion occurs in a small proportion of these tumors. PMID: 29092923
  2. Cotransin, a substrate-selective Sec61 inhibitor, traps nascent transmembrane domains in the cytosolic vestibule, permitting detailed interrogation of an early pre-integration intermediate. PMID: 24497544
Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein Families
SecE/SEC61-gamma family
Database Links

HGNC: 18277

OMIM: 609215

KEGG: hsa:23480

STRING: 9606.ENSP00000341538

UniGene: Hs.488282

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