SESN1 Antibody

Datasheet

Code	CSB-PA021095LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: K562 whole cell lysate, Hela whole cell lysate, NIH/3T3 whole cell lysate All lanes: SESN1 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 57, 64, 50 kDa Observed band size: 57 kDa Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA021095LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SESN1 Polyclonal antibody

Uniprot No.

Q9Y6P5

Target Names

SESN1

Alternative Names

1110002G11Rik antibody; AU044290 antibody; MGC118148 antibody; MGC138241 antibody; MGC142129 antibody; OTTMUSP00000022799 antibody; p53 activated gene 26 antibody; p53 regulated PA26 nuclear protein antibody; p53 regulated protein PA26 antibody; p53-regulated protein PA26 antibody; PA26 antibody; RP11-787I22.1 antibody; sesn1 antibody; SESN1_HUMAN antibody; SEST1 antibody; sestrin 1 antibody; Sestrin-1 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Sestrin-1 protein (224-337AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SESN1 Antibody (Product code: CSB-PA021095LA01HU) is Non-conjugated. For SESN1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA021095LB01HU	SESN1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021095LC01HU	SESN1 Antibody, FITC conjugated
Biotin	CSB-PA021095LD01HU	SESN1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.

Gene References into Functions

Study shows that SESN1 mRNA, UHRF1BP11 mRNA and miRNA-377-3p levels are prognostically relevant in human papillomavirus-negative head and neck squamous cell carcinoma patients. PMID: 28886272
The antitumor efficacy of pharmacological EZH2 inhibition depends on SESTRIN1, indicating that mTORC1 control is a critical function of EZH2 in lymphoma. PMID: 28659443
Mass spectrometry analysis, western blot and surface plasmon resonance (SPR) of affinity purified sesn1 and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 and sesn2 have a predominant a-helical structure. PMID: 28707664
this study shows that sestrin1 genetic ablation results in broad reconstitution of immune function in stressed T cells and enhanced vaccine responsiveness in old mice PMID: 28114291
Rapamycin may prohibit sestrin1 downregulation through targeting mTORC2 in appeasing low shear stress induced EC oxidative apoptosis PMID: 24587596
PA26 mutations are an infrequent cause of heterotaxia (situs inversus) in humans. PMID: 12607115
results show that sestrins, a family of proteins whose expression is modulated by p53, are required for regeneration of peroxiredoxins containing Cys-SO(2)H PMID: 15105503

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Subcellular Location

Nucleus. Cytoplasm.

Protein Families

Sestrin family

Tissue Specificity

Widely expressed.

Database Links

HGNC: 21595

OMIM: 606103

KEGG: hsa:27244

STRING: 9606.ENSP00000393762

UniGene: Hs.591336

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

p53 signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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