SESN1

Sestrin-1 is a protein in humans that is encoded by SESN1 gene. Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway.

The following SESN1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

SESN1 Antibodies

SESN1 Proteins

SESN1 Antibodies

SESN1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA021095GA01HU	SESN1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA195927	SESN1 Antibody	Human	ELISA,WB,IHC
CSB-PA008868	SESN1 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA569570	SESN1 Antibody	Human,Mouse	ELISA,WB
CSB-PA021095LA01HU	SESN1 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA021095LC01HU	SESN1 Antibody, FITC conjugated	Human
CSB-PA021095LD01HU	SESN1 Antibody, Biotin conjugated	Human	ELISA

SESN1 Proteins

SESN1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP021095MO CSB-EP021095MO CSB-BP021095MO CSB-MP021095MO CSB-EP021095MO-B	Recombinant Mouse Sestrin-1 (Sesn1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SESN1 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP021095XBE CSB-EP021095XBE CSB-BP021095XBE CSB-MP021095XBE CSB-EP021095XBE-B	Recombinant Xenopus laevis Sestrin-1 (sesn1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

SESN1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP706149MOV CSB-EP706149MOV CSB-BP706149MOV CSB-MP706149MOV CSB-EP706149MOV-B	Recombinant Macaca fascicularis Sestrin-1 (SESN1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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