SLC27A2 Antibody

Code CSB-PA021534GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
SLC27A2
Alternative Names
ACSVL1 antibody; FACVL1 antibody; FATP 2 antibody; FATP-2 antibody; FATP2 antibody; Fatty acid coenzyme A ligase, very long chain 1 antibody; Fatty acid transport protein 2 antibody; Fatty-acid-coenzyme A ligase antibody; hFACVL1 antibody; HsT17226 antibody; Long chain fatty acid CoA ligase antibody; Long-chain-fatty-acid--CoA ligase antibody; S27A2_HUMAN antibody; Slc27a2 antibody; Solute carrier family 27 (fatty acid transporter), member 2 antibody; Solute carrier family 27 member 2 antibody; THCA CoA ligase antibody; THCA-CoA ligase antibody; Very long chain acyl CoA synthetase antibody; Very long chain fatty acid CoA ligase antibody; Very long chain fatty acid coenzyme A ligase 1 antibody; very long-chain 1 antibody; Very long-chain acyl-CoA synthetase antibody; Very long-chain-fatty-acid-CoA ligase antibody; VLACS antibody; VLCS antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human SLC27A2
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IHC,IF
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acyl CoA synthetase that activates long-chain and very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA. Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid. Does not activate C24 bile acids, cholate and chenodeoxycholate. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Exhibits long-chain fatty acids (LCFA) transport activity and plays an important role in hepatic fatty acid uptake.; Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids. Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol.; Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.
Gene References into Functions
  1. In overweight/obese pregnancies, the increased FATP2 placental expression could contribute to increased fatty acid delivery to the fetus. PMID: 27016784
  2. In mice Grassofermata decreased absorption of (13)C-oleate demonstrating its potential as a therapeutic agent. PMID: 26284975
  3. Protective effects of breastfeeding are reflected in higher expression levels of SLC27A2, FASN, PPARalpha and INSR in blood cells. PMID: 24277691
  4. these data support the conclusion that FATP2 has a dual function in the pathways linking the transport and activation of exogenous fatty acids. PMID: 24113382
  5. FATP2a functions in fatty acid transport and activation and provides specificity toward n-3 fatty acids in which the corresponding n-3 acyl-CoAs are preferentially trafficked into acyl-CoA pools destined for phosphatidylinositol incorporation PMID: 21768100

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Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Peripheral membrane protein. Cell membrane; Multi-pass membrane protein. Microsome.
Protein Families
ATP-dependent AMP-binding enzyme family
Tissue Specificity
Expressed in liver, kidney, placenta and pancreas.
Database Links

HGNC: 10996

OMIM: 603247

KEGG: hsa:11001

STRING: 9606.ENSP00000267842

UniGene: Hs.11729

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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