SOX2 Antibody

1. SOX2 role in the squamous cancer progression.CCAT1 is a key target co-regulated by TP63 and SOX2 through a super-enhancer in squamous cancer cells. PMID: 30190462
2. Results demonstrated that SOX2 is a target of miR200c in MCF7/Tax cells. Knockdown of SOX2 expression increased chemosensitivity to paclitaxel and upregulated miR200c expression in MCF7/Tax cells. PMID: 30272330
3. BCL11A is integral to lung squamous cell carcinoma pathology and highlights the disruption of the BCL11A-SOX2 transcriptional programme as a novel candidate for drug development. PMID: 30127402
4. Hedgehog signaling (HH) and SOX2 function are inclined to developmental cues and arbitrating malignant growth in prostate cancer. SOX2 inhibition reduces cell proliferation and induces apoptosis. Conjoint inhibition of SOX2 and HH pathway induce apoptosis, reduce proliferation and migration. PMID: 27816521
5. The results remind us that clinical anophthalmia may be accompanied by sensorineural hearing loss and may be associated with SOX2 mutation, and it will contribute to improving diagnosis and patient care. PMID: 30262714
6. Metastatic double primary endometrioid endometrial and ovarian carcinoma sections expressed a higher level of SOX2 compared to the corresponding DPEEOC tissues. PMID: 29569698
7. The invasion and migration of osteosarcoma cells were down-regulated significantly through the inhibition of Sox2 by inactivating Wnt/beta-catenin signaling pathway related proteins PMID: 29619662
8. SOX2 is a critical oncogene linked to cancer stemness properties in urothelial carcinoma of the bladder. PMID: 29180467
9. Six SOX2 positive synovial sarcoma cases were analyzed by FISH using a SOX2/CEN3 dual color FISH probe PMID: 29773426
10. Tumor tissue Sox2 expression was not positively correlated with histologic grade, pathological tumor size and prognosis in surgical patients with triple-negative breast cancer. PMID: 29536377
11. Study in glioma stem-like cells (GSCs) identified SOX2 as one of downstream METTL3 targets and further recruitment of HuR onto m6A-modified sites in SOX2 is essential for SOX2 mRNA stabilization. METTL3 alters the DNA repair efficiency and radiation sensitivity partially via SOX2 in GSCs. PMID: 28991227
12. Myeloid Zinc Finger 1 and GA Binding Protein Co-Operate with Sox2 in Regulating the Expression of Yes-Associated Protein 1 in Cancer Cells PMID: 28905448
13. Human cytomegalovirus IE1 causes SOX2 downregulation by promoting the nuclear accumulation and inhibiting the phosphorylation of STAT3, a transcriptional activator of SOX2 expression. PMID: 29950413
14. hypopharyngeal squamous cell carcinomas characteristically almost completely lacking SOX2 expression appeared to be aggressive neoplasms with high recurrence rates. Promoter hypermethylation was determined to be a major mechanism underlying epigenetic SOX2 silencing PMID: 29143365
15. this study shows that basaloid squamous cell carcinoma and basal cell carcinoma of the head and neck can be readily distinguished by a limited panel consisting primarily of EMA, and supported by SOX2 and p16 PMID: 27438511
16. Results show that the levels of small nucleolar RNA host gene 5 (SNHG5) and SRY (sex determining region Y)-box 2 protein (SOX2) were significantly downregulated in osteoarthritis (OA) tissues, while the level of miR-26a was upregulated. PMID: 29409014
17. SOX2 copy number increases are detectable in a substantial proportion of high-grade HPV-positive vulvar carcinomas with basaloid differentiation. PMID: 28700423
18. The staining patterns did not reliably distinguish cervical intraepithelial neoplasia, grade 3 (CIN 3) from CIN 3-like Squamous cell carcinoma (SCC). Small infiltrative tumor nests around the margins of CIN 3 or deeply invasive CIN 3-like SCC often showed a localized reduction in SOX2 expression suggesting SOX2 downregulation during the transition to invasive growth. PMID: 28319578
19. Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage PMID: 29596469
20. SOX2 overexpression in DPSCs promoted the regulation of odontoblast differentiation of DPSCs PMID: 29039570
21. SOX2 expression is dependent on contact with enhancers 700 kb downstream via CTCFdependent chromatin looping. PMID: 29091765
22. LncRNA SOX2-OT is a novel prognostic biomarker for osteosarcoma patients, it regulates osteosarcoma cells proliferation and motility through SOX2 modulation, and is correlated with patients' survival. PMID: 28960757
23. SOX2 overexpression is associated with cancer. PMID: 29587142
24. Histone acetyltransferase EP300 is necessary for the transcription factor SOX2 activity in basal cells, including for induction of the squamous fate. EP300 copy number gains are common in squamous cell carcinoma SQCCs, including lung cancer SQCC cell lines. PMID: 28794006
25. NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ ALDH1A1 axis in lung adenocarcinoma. PMID: 28737489
26. Block the activation of the VRK1 promoter by Sox2. PMID: 27334688
27. Heterozygous loss-of-function mutations in SOX2 are the commonest cause of severe microphthalmia and anophthalmia. PMID: 28635421
28. This data demonstrated immunogenicity of SOX2, which is specifically overexpressed on pediatric glial tumor cells. PMID: 28620836
29. OCT4 and SOX2 work as transcriptional activators in reprogramming human fibroblasts. PMID: 28813671
30. Sox2-expressing cells mark a subpopulation of tumor cells that fuel the growth of established BCa. SOX2-positive cells also expressed other previously reported BCa CSC markers, including Keratin14 (KRT14) and CD44v6. Ablation of Sox2-expressing cells within primary invasive BCa led to enhanced tumor regression PMID: 28793245
31. studies on the role of SOX2 in breast cancer may provide effective biomarkers and potential therapeutic targets for the diagnosis and treatment of breast cancer PMID: 28674712
32. In conclusion, targeted sequencing for SOX2 and VSX2 identified the etiology in two patients (7.4%) and this is the first report of SOX2 mutation from Egypt. PMID: 28121235
33. Kat2b are essential to the differentiation through enhancing recruitment neuroectodermal factors Sox2 and Pax6 to their target sites. PMID: 28475175
34. combined administration of small-interfering RNA (siRNA) transfection with PPARgamma ligands induced downregulation of SOX2 and MMP2 activity together with inhibition of sphere-forming activity regardless of poly(ADP-ribose) polymerase (PARP) cleavage. Taken together, our findings suggest that a combination therapy using PPARgamma ligands and its inhibitor could be a potential therapeutic strategy targeting glioblastom... PMID: 28642874
35. DDX53 directly regulates the SOX-2 expression in drug-resistant melanoma cells. PMID: 28535666
36. Rectal tumor tissue OCT4 (p<0.001), SOX2 (p=0.003), and NANOG (p<0.001) expressions were higher than those in adjacent tissue. PMID: 29214774
37. Thus, SOX2 is a master regulator of the acinar cell lineage essential to the establishment of a functional organ. PMID: 28623666
38. Results provide evidence that SOX2 expression is regulated by the transcription factor HSF1. PMID: 29316077
39. SOX2 overexpression and the loss of Rb1 protein expression might have a pivotal role in the divergent differentiation of pluripotent embryonic-like epithelial cells and the development of esophageal small-cell carcinoma. PMID: 28106103
40. In SOX2-deficient cells, BMP signaling is inhibited, but NODAL signaling is not activated. Thus, SOX2 appears to be downstream of BMP signaling but upstream of NODAL activation. PMID: 27283990
41. Results show lower SOX2 in the lymph node metastases from head and neck squamous cell carcinomas (HNSCCs) and in cervical cancer of unknown primary patients compared with the primary tumor. Tumors from N1 to N3 stage exhibit decreasing SOX2 expression in the lymphatic metastases. Its expression is showed to be involved in the proliferation and migration of HNSCC cell lines. PMID: 28002801
42. SOX2 overexpression could be used as a positive prognostic factor in patients with stage III lung squamous cell carcinoma receiving adjuvant radiotherapy PMID: 26323639
43. The survival rate was increased by 11.1% in Oct4/Sox2-hAT-MSC-injected mice. PMID: 28438862
44. hypoxia-NOTCH1-SOX2 signaling axis is important for activation of ovarian cancer stem cells. PMID: 27489349
45. This severe movement disorder appears to be a feature of some types of SOX2-anophthalmia syndrome thus expanding the phenotype. We strongly recommend that all newborns with bilateral anophthalmia/microphthalmia be screened for mutations in SOX2 PMID: 27427475
46. Findings indicate that long-term exposure to IM results in dysregulation of stem cell renewal-regulatory Hippo (MST1/2)/YAP signaling, and that inhibition of miR-181a using a microRNA sponge inhibitor resulted in decreased transcription of SOX2 and SALL4. PMID: 28103766
47. The authors found that high/positive SOX2 alterations, either DNA amplification or protein expression, were favorable for overall survival (OS) in non-small cell lung cancer. On the contrary, high/positive Nestin protein expression was poor for OS. PMID: 27150062
48. Data show that tunicamycin reduces the expression of self-renewal regulator Sox2 at translation level. PMID: 27119230
49. Increasing SOX2 reduces growth inhibition mediated by MEK and AKT inhibitors; whereas knockdown of SOX2 further reduces growth when Pancreatic ductal adenocarcinoma cells are treated with these inhibitors. Thus, targeting SOX2, or its mode of action, could improve the treatment of Pancreatic ductal adenocarcinoma. PMID: 27145457
50. This study discloses novel SOX2 target genes driving neuroendocrine differentiation and spread of PC and proposes SOX2 as a functional biomarker of LN metastasization for prostate cancer. PMID: 26540632
51. These results suggest that SOX2 may play an important role in carcinogenesis and progression of invasive carcinoma ex pleomorphic adenoma PMID: 28842747
52. A positive feedback loop involving the Wnt/beta-catenin/MYC/Sox2 axis defines a highly tumorigenic cell subset in ALK + anaplastic large cell lymphoma. PMID: 27821172
53. highly conserved Sox2/Pax6 bound site near the Sprouty2 locus was verified to promote cooperative dimerization designating Sprouty2 as a potential target reliant on Sox2/Pax6 cooperativity in several neural cell types. PMID: 29050852
54. High SOX2 expression is associated with brain neoplasms. PMID: 28933914
55. we demonstrated that CD59 regulation by SOX2 is required for stem cell evasion of complement surveillance. This finding highlights the importance of complement surveillance in eliminating CSCs and may suggest CD59 as a potential target for cancer therapy. PMID: 28017655
56. SOX2 repression in TCam-2 cells can be abrogated by recruitment of the constitutively expressed H3K27 demethylase UTX to the SOX2 promoter through retinoid signaling, leading to expression of neuronal and other lineage genes. SOX17 has been shown to initiate human PGC specification, with its target PRDM1 suppressing mesendodermal genes PMID: 27132888
57. High SOX2 expression is associated with melanoma. PMID: 27105574
58. SOX2 induced human neonatal/adult retinal pigment epithelial cells to de-differentiate toward retinal progenitor cells. PMID: 28480968
59. The anterior pituitary gland comprised specialized cell-types that arise from stem cells expressing SOX2 and PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. [review] PMID: 27650955
60. Results show that AR inhibits BRN2 regulation of SOX2, another transcription factor associated with neuroendocrine prostate cancer. PMID: 27784708
61. Knockdown of SOX2 could reverse these phenotypes. PMID: 28182001
62. High SOX2 expression is associated with pancreatic ductal adenocarcinoma. PMID: 28867247
63. This study revealed that miR-101 plays a critical role in suppressing tumor progression by directly targeting SOX2. PMID: 28946143
64. Results show that BPA induced SOX2 mRNA and protein in MCF-7 mammospheres, resulting from enhanced CREB phosphorylation, and subsequent binding of pCREB to a SOX2 downstream enhancer. Also, BPA activation of SOX2 seems to enhance cancer stem-like cell activity which contributes to breast cancer tumor maintenance. PMID: 28244015
65. In our three patients and four further, reported "genotype first" SOX2 microdeletion patients, anophthalmia/microphthalmia was present in less than half of the patients. Thus, SOX2 is another example of a gene whose clinical spectrum is broadened by the generation of "genotype first" findings using hypothesis-free, genome-wide methods. PMID: 27862890
66. These data suggest that elevated expression of SOX2 can activate lncRNA PVT1 expression promoted breast cancer tumorigenesis and progression. PVT1 may be a prognostic predictive biomarker for breast cancer, and the interaction of PVT1-SOX2 could be a therapeutic target in breast cancer. PMID: 28882595
67. In addition to its angiogenic action, VEGFA upregulates Sox2 to drive stem cell expansion, together with miR-452 loss and Slug upregulation, providing a novel mechanism whereby cancer stem cells acquire metastatic potential. PMID: 28504716
68. SOX2 expression induces a cellular stem cell state in human colorectal cancer with a decreased expression of CDX2. PMID: 27411517
69. FOXG1 and SOX2 operate in complementary but distinct roles to fuel unconstrained self-renewal in Glioblastoma multiforme stem cells via transcriptional control of core cell cycle and epigenetic regulators. PMID: 28465359
70. Sox2 plays an essential role in melanocyte transformation and melanoma growth. PMID: 28368402
71. The lack of a tumorigenic role of Sox2 in melanoma might reflect a distinct stem cell program active in neural crest stem cells and during melanoma formation. PMID: 28368416
72. Results suggest that the simultaneous evaluation of SRY (sex determining region Y)-box 2 protein (SOX2) and cyclin dependent kinase inhibitor 1A (p21) in advanced endometrial cancer patients provides more accurate information for patient prognosis than either alone. PMID: 28188685
73. Results suggest that targeting SRY (sex determining region Y)-box 2 protein (SOX2) in ovarian cancer may be therapeutically beneficial. PMID: 28165651
74. Endogenous Plastic Somatic (ePS) cells in a latent state, i.e. lacking SOX2, OCT3/4 and NANOG (SON) expression, in non-diseased breast specimens through immunohistochemical analysis of previously identified ePS-specific biomarkers (CD73(+), EpCAM(+) and CD90(-)). PMID: 27705752
75. Our results not only revealed the genetic plasticity contributing to drug resistance and stemness but also demonstrated the dominant role of SOX2 in maintenance of glioblastoma cancer stem cells. PMID: 27530866
76. We show that the chromatin remodeling protein HMGA1 functions as a downstream effector of these biological responses to miR-296-5p and regulates Sox2 expression, a master driver of cell stemness, by modifying chromatin architecture at the Sox2 promoter PMID: 26898758
77. PARP-1 stabilizes Sox2 binding to nucleosomes at suboptimal sites through cooperative interactions on DNA to regulate Sox2 pioneer activity at intractable genomic loci. PMID: 28212747
78. Sox2 has a role in location and progression of gastric cancer PMID: 28046028
79. Model highlights the essential role of SOX2 in commanding the squamous cell fate from different cells of origin and represents an invaluable tool for developing better intervention strategies. PMID: 27728803
80. Our findings suggest that miR-429 represents a potential tumour-suppressive miRNA and plays an important role in glioblastoma multiforme (GBM)progression by directly targeting SOX2. PMID: 28749077
81. Data indicate that microRNA miR-625 targets the 3' untranslated region (3'-UTR) of SRY-box 2 transcription factor SOX-2 (SOX2). PMID: 28129648
82. SOX2 is a main downstream regulator of SIRT1-mediated self-renewal and tumorigenicity potential of liver cancer stem cells PMID: 27312708
83. SOX2 is a single-exon nuclear transcription factor with critical roles in stem cell and developmental biology, and is particularly important in the development of the lung. PMID: 28199128
84. antiandrogen resistance of prostate cancer can be reversed by inhibiting SOX2. PMID: 28059768
85. We observed an upregulation of the transcription factors OCT4 and SOX2 in leukemic cells as compared to normal cells. Conversely, SSEA1 protein was downregulated in leukemic cells. The expression of OCT4, SOX2, and SSEA3 was higher in CD34(+)CD38(-) than in CD34(+)CD38(+) subsets in leukemic cells. PMID: 28718379
86. SOX2 regulates the proliferation, migration and invasiveness of breast cancer cells through miR-181a-5p and miR-30e-5p which modulate TUSC3 protein levels PMID: 28288641
87. PI3K signaling enhanced SOX2 translation, which in turn induced the expression of genes regulating the stemness characteristics of cancer stem cells . PMID: 27634934
88. SOX2 loss is associated with oral cancer. PMID: 27123539
89. Aberrant DNA methylation of SOX2 and CDX2 genes contributes to the development of IM. Notably, SOX2 may play a role in establishing and maintaining the methylation status of the CDX2 gene in gastric tissues and cells. PMID: 27913994
90. Data show that Nanog homebox (NANOG) but not sex-determining region Y-box2 (SOX2) and octamer-binding protein 4 (OCT4) expression was overexpressed in the endometrium of women with intrauterine adhesion (IUA). PMID: 28253866
91. demonstrates the mitotic bookmarking property of SOX2 and reveals its functional importance in pluripotency maintenance and ES cell differentiation. PMID: 27920086
92. These findings reveal a novel regulation mechanism of SOX2 phosphorylation mediated by AURKA in mitosis and its function in stem cell pluripotency maintenance in cancer cells. PMID: 27249336
93. Pattern of p53 and particularly SOX2 protein expression in esophageal adenocarcinoma predicts response to neoadjuvant chemoradiotherapy. PMID: 28059963
94. photoinduced excess electron transfer assay can be used for analysing cooperativity of proteins in transcription complex using cooperative binding of Pax6 to Sox2 on the regulatory DNA element (DC5 enhancer) as an example. PMID: 27229137
95. Sox2 may be an important regulator in development of chemoresistance of lung cancer cells. PMID: 28259951
96. find that SOX2 cooperates with PI3K signaling, which is activated by smoking, to initiate the squamous injury response in basal cells. This response involves SOX9 repression, and, accordingly, SOX2 and PI3K signaling levels are high during dysplasia, while SOX9 is not expressed PMID: 27880766
97. The data indicate that both OCT4 and SOX2 play important roles in the development of Barrett Esophagus triggered by bile acid reflux. PMID: 27096226
98. Results show that Sox2 and PD-L1 expression are significantly higher in hepatocellular carcinoma tissues (HCC) and that Sox2 transactivates PD-L1 through its promoter providing a novel insight into the function and the interplay of Sox2 and PD-L1 in HCC. PMID: 28339084
99. Oct4/Lys-156-modulated Oct4/Sox2 interaction coordinately controls the epithelial-mesenchymal transition and mesendoderm specification induced by specific differentiation signals. PMID: 27369080
100. Osteosarcoma spheres are slowly-proliferating populations, overexpress SOX2, and KLF4 stemness-related genes and have enhanced tumorigenic potential. PMID: 26332365

Show More

Hide All

HGNC: 11195

OMIM: 184429

KEGG: hsa:6657

STRING: 9606.ENSP00000323588

UniGene: Hs.518438