SOX2 Antibody

Datasheet
Code CSB-PA982860
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P48431
Image
  • Western blot analysis of extracts from human Umbilical cord mesenchymal stem cell using SOX2 Antibody.
Immunogen Peptide sequence around aa.76~80 (G-A-E-W-K) derived from SOX2
Raised in Rabbit
Species Reactivity Human,Mouse
Specificity The antibody detects endogenous level of total SOX2 protein.
Tested Applications ELISA,WB;WB:1:500-1:1000
Relevance Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency

Yuan H, et al. Genes Dev. 1995 Nov 1;9(21):2635-45
Muta M, et al. Genes Cells 2002 Aug;7(8):791-805
Tomioka M, et al. Nucleic Acids Res. 2002 Jul 15; 30(14): 3202-3213.
Form Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality Polyclonal
Alias Transcription factor SOX-2
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names SOX2
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Involvement in disease Microphthalmia, syndromic, 3 (MCOPS3)
Subcellular Location Nucleus
Database Links

HGNC: 11195

OMIM: 184429

KEGG: hsa:6657

STRING: 9606.ENSP00000323588

UniGene: Hs.518438

Pathway Hippo signaling pathway
Signaling pathways regulating pluripotency of stem cells

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