SPAM1 Antibody

Code CSB-PA022471LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) SPAM1 Polyclonal antibody
Uniprot No.
Target Names
SPAM1
Alternative Names
epididymis secretory sperm binding protein Li 96n antibody; HEL-S-96n antibody; HYA1 antibody; HYAL PH-20 antibody; HYAL PH20 antibody; Hyal-PH20 antibody; HYAL1 antibody; HYAL3 antibody; HYAL5 antibody; HYALP_HUMAN antibody; Hyaluronidase PH-20 antibody; Hyaluronoglucosaminidase PH-20 antibody; MGC26532 antibody; PH-20 Hyaluronidase antibody; PH20 antibody; PH20 Hyaluronidase antibody; SPAG15 antibody; SPAM-1 antibody; Spam1 antibody; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) antibody; Sperm adhesion molecule 1 antibody; Sperm surface protein PH-20 antibody; Sperm surface protein PH20 antibody; zona pellucida binding antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Hyaluronidase PH-20 protein (36-490AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The SPAM1 Antibody (Product code: CSB-PA022471LA01HU) is Non-conjugated. For SPAM1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA022471LB01HU SPAM1 Antibody, HRP conjugated ELISA
FITC CSB-PA022471LC01HU SPAM1 Antibody, FITC conjugated
Biotin CSB-PA022471LD01HU SPAM1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The polyclonal antibody CSB-PA022471LA01HU was produced in rabbits against SPAM1 using recombinant human Hyaluronidase PH-20 protein (36-490aa) as the immunogen. After the purification process using protein G affinity chromatography, the antibody achieved a purity level of up to 95%.

This SPAM1 polyclonal antibody is specific to human SPAM1 proteins and may be used to detect the endogenous levels of SPAM1 protein. Quality testing has been conducted specifically for ELISA, allowing users to quantitatively or qualitatively measure the SPAM1 protein with this antibody.

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Target Background

Function
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
Gene References into Functions
  1. Human posterior head 20 (hPH20) and homo sapiens sperm acrosome associated 1 (hSPACA1) immunocontraceptive epitopes reduced fertility in male/female mice. PMID: 25209425
  2. results indicate that neither rHuPH20 nor its directly generated HA catabolites have inflammatory properties in the air pouch model, and rHuPH20 can instead inhibit some aspects of inflammation, such as neutrophil infiltration into the air pouch. PMID: 24778442
  3. HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A and SPAM1. PMID: 23247813
  4. The interaction between SPAM1, ARSA and HSPA2 in a multimeric complex mediating sperm-egg interaction. PMID: 23209833
  5. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination. PMID: 23463525
  6. SPAM1 mRNA & protein occur in all 3 regions of epididymis & vas deferens. It has hyaluronidase activity at pH 7.0. The proximal promoter has epididymal transcription factor sites including androgen receptor elements. Its role may be in sperm maturation. PMID: 12932297

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Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families
Glycosyl hydrolase 56 family
Tissue Specificity
Testis.
Database Links

HGNC: 11217

OMIM: 600930

KEGG: hsa:6677

STRING: 9606.ENSP00000345849

UniGene: Hs.121494

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