SPAM1 Antibody, FITC conjugated

Code CSB-PA022471LC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) SPAM1 Polyclonal antibody
Uniprot No. P38567
Target Names SPAM1
Alternative Names epididymis secretory sperm binding protein Li 96n antibody; HEL-S-96n antibody; HYA1 antibody; HYAL PH-20 antibody; HYAL PH20 antibody; Hyal-PH20 antibody; HYAL1 antibody; HYAL3 antibody; HYAL5 antibody; HYALP_HUMAN antibody; Hyaluronidase PH-20 antibody; Hyaluronoglucosaminidase PH-20 antibody; MGC26532 antibody; PH-20 Hyaluronidase antibody; PH20 antibody; PH20 Hyaluronidase antibody; SPAG15 antibody; SPAM-1 antibody; Spam1 antibody; sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) antibody; Sperm adhesion molecule 1 antibody; Sperm surface protein PH-20 antibody; Sperm surface protein PH20 antibody; zona pellucida binding antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Hyaluronidase PH-20 protein (36-490AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid.
Gene References into Functions
  1. Human posterior head 20 (hPH20) and homo sapiens sperm acrosome associated 1 (hSPACA1) immunocontraceptive epitopes reduced fertility in male/female mice. PMID: 25209425
  2. results indicate that neither rHuPH20 nor its directly generated HA catabolites have inflammatory properties in the air pouch model, and rHuPH20 can instead inhibit some aspects of inflammation, such as neutrophil infiltration into the air pouch. PMID: 24778442
  3. HSPA2 regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A and SPAM1. PMID: 23247813
  4. The interaction between SPAM1, ARSA and HSPA2 in a multimeric complex mediating sperm-egg interaction. PMID: 23209833
  5. PH20 is elevated in demyelinating lesions and that increased PH20 expression is sufficient to inhibit oligodendrocyte precursor cell maturation and remyelination. PMID: 23463525
  6. SPAM1 mRNA & protein occur in all 3 regions of epididymis & vas deferens. It has hyaluronidase activity at pH 7.0. The proximal promoter has epididymal transcription factor sites including androgen receptor elements. Its role may be in sperm maturation. PMID: 12932297

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Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor
Protein Families Glycosyl hydrolase 56 family
Tissue Specificity Testis.
Database Links

HGNC: 11217

OMIM: 600930

KEGG: hsa:6677

STRING: 9606.ENSP00000345849

UniGene: Hs.121494

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