SQSTM1 Antibody

Datasheet
Code CSB-PA022647GA01HU
Product Type Purified Rabbit Anti human PolyClonal Antibody
Size US$685
Uniprot No. Q13501
Immunogen Human SQSTM1
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB,IF
Storage Buffer PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias sequestosome 1;SQSTM1;A170;OSIL;PDB3;ZIP3;p60;p62;p62B ;
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Target Names SQSTM1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.
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Function Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family
Involvement in disease Paget disease of bone 3 (PDB3); Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (FTDALS3); Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset (NADGP); Myopathy, distal, with rimmed vacuoles (DMRV)
Subcellular Location Cytoplasm, cytosol, Late endosome, Lysosome, Cytoplasmic vesicle, autophagosome, Nucleus, Endoplasmic reticulum, Nucleus, PML body, Cytoplasm, myofibril, sarcomere
Tissue Specificity Ubiquitously expressed.
Database Links

HGNC: 11280

OMIM: 167250

KEGG: hsa:8878

STRING: 9606.ENSP00000374455

UniGene: Hs.587290

Pathway Cellular senescence
Necroptosis
Osteoclast differentiation

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