Recombinant Human Sequestosome-1(SQSTM1)

1. Study shows that p62 hijacked NOXA for its degradation during autophagy. PMID: 29758299
2. A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy. PMID: 30022074
3. Study demonstrated that the expression of p62 was upregulated in 4nitroquinoline1oxideinduced oral carcinogenesis, accompanied with myeloidderived suppressor cells and regulatory T cells accumulation. PMID: 30272335
4. High p62 cytoplasmic expression on its own (p PMID: 29897944
5. the complex structures between the ZZ-domain of p62 and various type-1 and type-2 N-degrons, are reported. PMID: 30120248
6. the role of p62 in energy metabolism was studied in fibroblasts. PMID: 28490746
7. p62 and ubiquitinated proteins spontaneously coalesce into larger clusters. Efficient cluster formation requires substrates modified with at least two ubiquitin chains longer than three moieties and is based on p62 filaments cross-linked by the substrates. PMID: 29343546
8. 27-OH induced autophagy is dependent on the relation between nuclear factor erythroid 2 p45-related factor 2 (Nrf2)-dependent antioxidant response and p62. PMID: 29879549
9. our results showed that high CD44 led to p62-associated NRF2 activation in CD44(high) breast CSC-like cells. NRF2 activation contributed to the aggressive phenotype, tumor growth, and anticancer drug resistance of CD44(high) CSCs PMID: 29729523
10. results suggested that p62 plays a protective role in adipogenesis of human adipose-derived stromal cells through regulating mitophagy. PMID: 29866118
11. The results of the present study demonstrated that p62 may aggravate LPSinduced acute kidney injury in mice by promoting apoptosis in renal tubular epithelial cells. PMID: 29620262
12. Study supports HuR's role as an upstream regulator of p62 expression in ARPE-19 cells, helps to understand better the early events in response to a proautophagy stimulus. PMID: 29576851
13. Therefore in this review we discuss the role of p62 in autophagy, apoptosis and cancer through its different domains and outline the importance of modulating cellular levels of p62 in cancer therapeutics. PMID: 29738493
14. Both the metastatic and recurrent tumor tissues expressed less p62 than the patient-matched primary tumor. A significant inverse correlation has been found between p62 expression and both the disease-free survival and overall survival. PMID: 29699801
15. p62 deficiency in stromal fibroblasts promotes resistance to glutamine deprivation by the direct control of ATF4 stability through its p62-mediated polyubiquitination. PMID: 28988820
16. AGG is also found to trigger ubiquitination of PUMA which in turn interacted with p62 for prompting mitophagy suggesting that AGG turns on PUMA-mediated mitophagy in U87MG cells in both p62-dependent as well as in p62-independent manner PMID: 29229477
17. The results suggest that p62 may be an effective predictor of prognosis and a potential target for therapy in osteosarcoma. PMID: 29617702
18. The model reveals a compensatory autophagic pathway, mediated by a SQSTM1/p62-dependent clearance of accumulated polyubiquitinated proteins. In addition to mediating the sequestration of ubiquitinated cargos into phagophores, the precursors to autophagosomes, SQSTM1 is also important for polyubiquitinated aggregate formation upon proteasomal inhibition. PMID: 28792301
19. ESI induces protective autophagy of lung cancer cells through Nrf2-p62-keap1 feedback loop PMID: 28617433
20. IFN-gamma induces activated but insufficient autophagy and thus contributes to a degree to p62-dependent apoptosis of nasal epithelial cells in chronic rhinosinusitis with nasal polyps. PMID: 28258963
21. The underling mechanism of autophagy/p62/Nrf2 pathway discovered may provide a new direction for drug development. PMID: 28737825
22. Study show the proteasome autophagy mechanism is mediated by the p62/SQSTM1 adapter and requires its ubiquitin-associated domain. Independently, p62 serves also as a shuttling protein for ubiquitinated substrates, using its PB1 domain. This places p62 in a pivotal position where under certain conditions it binds to the proteasome as a protease, whereas in other conditions it recognizes the proteasome as a prey. PMID: 27791183
23. The study describes a previously uncharacterized cellular response induced by heme: the formation of p62/SQSTM1 aggregates containing ubiquitinated proteins in structures known as aggresome-like induced structures (ALIS). This action is part of a response driven by the transcription factor NRF2 to the excessive generation of reactive oxygen species induced by heme. PMID: 27821769
24. The data identify an intricate mechanism of hepatitis C virus-dependent inhibition of Nrf2/ antioxidant response elements-mediated gene expression which counteracts serine 349-phosphorylated p62-induced activation of Nrf2. PMID: 28673615
25. Results identified SQSTM1, a regulator of apoptosis and autophagy, to be hyper-phosphorylated and associated with development of cisplatin resistance in high-grade serous ovarian cancer. PMID: 28455291
26. p62 immunoreactivity was detected in 11% of colorectal adenoma and 31% of the adenocarcinoma cases, and almost negligible in the normal epithelium. p62 promotes cell proliferation in colorectal carcinoma cells, was significantly associated with synchronous liver metastasis in the colorectal carcinoma cases, and was an independent adverse prognostic factor for overall survival in the colorectal cancer patients. PMID: 28544335
27. NEDD4 is an autophagic E3 ubiquitin ligase that ubiquitylates SQSTM1, facilitating SQSTM1-mediated inclusion body autophagy. PMID: 29021346
28. SQSTM1/p62 senses the saturation of reactive oxygen species (ROS)-buffering systems, and that this redox-sensitivity is important to increase autophagy, and thus ensure the survival of cells under oxidative stress conditions. PMID: 29343728
29. This study is the first to show a cytoplasmic function of claudin 1 as an autophagy regulator and provides the evidence that claudin 1-mediated autophagy regulation is an integral part of the mechanism by which claudin 1 regulates cancer progression. PMID: 29307823
30. The autophagy induced by 2-PCPA requires LC3-II processing machinery..2-PCPA treatment induces the change of global gene expression program, including a series of autophagy-related genes, such as SQSTM1/p62. Taken together, our data indicate that KDM1A/LSD1 inhibitors induce autophagy through affecting the expression of autophagy-related genes and in a BECN1-independent manner PMID: 28800922
31. The results of this study reflect that Frontotemporal Dementia /SQSTM1 carriers show a right atrophy pattern in prefrontal-orbital-insular regions with relative preservation of the temporal lobes different from that observed in Sporadic Frontotemporal Dementia. PMID: 27163810
32. the L341V mutation limits the critical step of SQSTM1 recruitment to the phagophore PMID: 27158844
33. Endogenous p62 undergoes E2-dependent ubiquitylation during upregulation of Ubiquitin (Ub) homeostasis, a condition termed as Ub(+) stress, that is intrinsic to Ub overexpression, heat shock or prolonged proteasomal inhibition by bortezomib, a chemotherapeutic drug. PMID: 28322253
34. LC3 and p62/SQSTM1 have roles in early-stage non-small cell lung cancer PMID: 27250032
35. LC3B and p62 have roles in autophagy in esophageal adenocarcinoma PMID: 27250034
36. ALS-FTLD associated mutations of SQSTM1 disrupt Keap1 binding and disable Nrf2 signaling. PMID: 27554286
37. analysis of soluble SQSTM1 complexes and soluble complexes formed between SQSTM1 oligomers and LC3 using a combination of fluorescence microscopy-based biophysical approaches in living cells PMID: 27442348
38. CAL suppresses the expression of pro-inflammatory cytokines via p62/Nrf2-linked HO-1 induction in RASFs. PMID: 27678042
39. Vps34 stimulates tumor development mainly through PKC-delta- activation of p62. PMID: 28846113
40. casein kinase 1 phosphorylates the SQSTM1 S349 residue when harmful proteins accumulate under HSF1 stress PMID: 27846364
41. SQSTM1 binds and inhibits E3 ligase RNF168s activity, which is essential for H2A ubiquitination PMID: 27791533
42. this study proved that SYVN1 enhances SERPINA1(E342K)/ATZ degradation through SQSTM1-dependent autophagy and attenuates SERPINA1(E342K)/ATZ cytotoxicity. PMID: 28121484
43. The authors show that ufmylation regulates SQSTM1 by eliciting a cell type-specific endoplasmic reticulum stress response which induces SQSTM1 expression and results in its accumulation in the cytosol. PMID: 27351204
44. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy. PMID: 27498865
45. These data define that YOD1 antagonizes TRAF6/p62-dependent IL-1 signaling to NF-kappaB. PMID: 28244869
46. Data show that p62 interaction with LC3, leading to the delivery of p62 and its cargoes to the autophagosome. PMID: 28740232
47. These results demonstrate a novel SQSTM1 regulatory network that promotes a nickel-induced tumorigenic effect in human bronchial epithelial cells. PMID: 27467530
48. Thyroid hormone promotes selective autophagy via induction of DAPK2-SQSTM1 cascade, which in turn protects hepatocytes from diethylnitrosamine-induced hepatotoxicity or carcinogenesis. PMID: 27653365
49. P62 functions as a tumour metastasis promoter. PMID: 28968743
50. Silence of p62 promotes apoptosis induced by mitochondrial depolarization. PMID: 28433685

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HGNC: 11280

OMIM: 167250

KEGG: hsa:8878

STRING: 9606.ENSP00000374455

UniGene: Hs.587290