SQSTM1 Antibody, HRP conjugated

Datasheet
Code CSB-PA615696LB01HU
Size US$299
Uniprot No. Q13501
Immunogen Recombinant Human Sequestosome-1 protein (16-310AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62), SQSTM1, ORCA OSIL
Immunogen Species Human
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names SQSTM1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family
Involvement in disease Paget disease of bone 3 (PDB3); Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 (FTDALS3); Neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset (NADGP); Myopathy, distal, with rimmed vacuoles (DMRV)
Subcellular Location Cytoplasm, cytosol, Late endosome, Lysosome, Cytoplasmic vesicle, autophagosome, Nucleus, Endoplasmic reticulum, Nucleus, PML body, Cytoplasm, myofibril, sarcomere
Tissue Specificity Ubiquitously expressed.
Database Links

HGNC: 11280

OMIM: 167250

KEGG: hsa:8878

STRING: 9606.ENSP00000374455

UniGene: Hs.587290

Pathway Cellular senescence
Necroptosis
Osteoclast differentiation

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