ST3GAL3 Antibody

Code CSB-PA606136LA01HU
Size US$299 How to order?
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  • Western blot
    All lanes: ST3GAL3 antibody at 2µg/ml + Mouse skeletal muscle tissue
    Secondary
    Goat polyclonal to rabbit lgG at 1/15000 dilution
    Predicted band size: 43, 44, 20, 50, 39, 22, 32, 13, 21, 14, 18, 49, 17, 41, 31, 16, 47, 26, 27, 12, 23, 6, 9 kDa
    Observed band size: 43 kDa
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Product Details

Description

The peptide corresponding to amino acid residues 29-375 of the human ST3GAL3 protein is used to immunize rabbits to produce the ST3GAL3 antibody. This resulting antibody is a polyclonal antibody and occurs as an unconjugated IgG. Its purity is 95%+ using protein G purified. It can cross-react with human and mouse ST3GAL3 protein. And it is available for use in ELISA and WB applications. The target protein ST3GAL3 is a type II membrane protein responsible for catalyzing the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. It is involved in the pathogenesis of mental retardation, autosomal recessive 12 (MRT12) and epileptic encephalopathy, early infantile, 15 (EIEE15).

Full Product Name Rabbit anti-Homo sapiens (Human) ST3GAL3 Polyclonal antibody
Uniprot No. Q11203
Target Names ST3GAL3
Alternative Names 3 sialyltransferase antibody; 3(4) GlcNAc alpha-2 antibody; 3-sialyltransferase 3 antibody; 3-sialyltransferase antibody; 3-ST 3 antibody; 4-galactoside alpha-2 antibody; 4GlcNAc alpha 2 3 sialyltransferase antibody; Alpha 2 3 sialyltransferase II antibody; Alpha 2 3 sialyltransferase III antibody; Alpha 2 3 ST 3 antibody; Alpha 2 antibody; Beta galactoside alpha 3 sialyltransferase 3 antibody; Beta-galactoside alpha-2 antibody; CMP N acetylneuraminate beta 1 4 galactoside alpha 2 3 sialyltransferase antibody; CMP-N-acetylneuraminate-beta-1 antibody; EC 2.4.99.6 antibody; Gal beta 1 3 antibody; Gal beta 1 3(4) GlcNAc alpha 2 3 sialyltransferase antibody; Gal beta 1 3(4)GlcNAc alpha 2 3 sialyltransferase antibody; Gal beta-1 antibody; N acetyllactosaminide alpha 2 3 sialyltransferase antibody; N-acetyllactosaminide alpha-2 antibody; OTTHUMP00000008820 antibody; OTTHUMP00000008821 antibody; OTTHUMP00000008822 antibody; OTTHUMP00000008823 antibody; Sialyltransferase 6 (N acetyllacosaminide alpha 2 3 sialyltransferase) antibody; Sialyltransferase 6 antibody; SIAT6 antibody; SIAT6_HUMAN antibody; ST3 beta galactoside alpha 2 3 sialyltransferase 3 antibody; ST3 beta galactoside alpha 2,3 sialyltransferase 3 antibody; ST3Gal III antibody; St3gal3 antibody; ST3GALII antibody; ST3GalIII antibody; ST3N antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase protein (29-375AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated

The ST3GAL3 Antibody (Product code: CSB-PA606136LA01HU) is Non-conjugated. For ST3GAL3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA606136LB01HU ST3GAL3 Antibody, HRP conjugated ELISA
FITC CSB-PA606136LC01HU ST3GAL3 Antibody, FITC conjugated
Biotin CSB-PA606136LD01HU ST3GAL3 Antibody, Biotin conjugated ELISA
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Applications : Immunohistochemistry

Sample type: cells

Review: ST3Gal3 immunostaining was observed in cytoplasmic (17samples, 94.44%) and membrane (1 sample, 5.56%) regions on GC cells.

By Anonymous

Target Background

Function
Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc.
Gene References into Functions
  1. CA19.9 appears as a physiological product whose synthesis strongly depends on the tissue specific and epigenetically-regulated expression of B3GALT5 and ST3GAL3. PMID: 27535614
  2. ST3Gal3 knockdown synergistically enhanced cisplatin-induced apoptosis in ovarian cancer cells PMID: 27871859
  3. ST3Gal III modulates breast cancer cell adhesion and invasion by altering the expression of invasion-related molecules. PMID: 27779707
  4. Dysfunctional ST3GAL3 may result in perturbation of the posttranslational sialylation of proteins in these pathways PMID: 23252400
  5. ST3GAL3 mutations impair the development of higher cognitive functions. PMID: 21907012
  6. Characterization of the promoter region of the ST3Gal III gene. PMID: 12697334
  7. 19 different transcripts of ST3GalIII were isolated and cloned; tissue distribution analysis showed complex patterns in neural and muscular tissues PMID: 12815231
  8. High levels of ST3GAL-III in the tumor tissue correlated with secondary local tumor recurrence (p = 0.005; p = 0.012). PMID: 12931020
  9. Identification of a new ST3Gal3 transcript from fetal brain. PMID: 15316282

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Involvement in disease Mental retardation, autosomal recessive 12 (MRT12); Epileptic encephalopathy, early infantile, 15 (EIEE15)
Subcellular Location Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Protein Families Glycosyltransferase 29 family
Tissue Specificity Highly expressed in adult skeletal muscle and in all fetal tissues examined and to a much lesser extent in placenta, lung and liver.
Database Links

HGNC: 10866

OMIM: 606494

KEGG: hsa:6487

UniGene: Hs.597915

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