STAT6 Antibody

Code CSB-PA022816LA01HU
Size US$299Purchase it in Cusabio online store
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  • Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA022816LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA022816LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) STAT6 Polyclonal antibody
Uniprot No. P42226
Target Names STAT6
Alternative Names 12S1644 antibody; D12S1644 antibody; IL 4 STAT antibody; IL-4 Stat antibody; IL4 STAT antibody; Interleukin 4 Induced antibody; Interleukin 4 Induced Transcription Factor IL4 STAT antibody; Signal transducer and activator of transcription 6 antibody; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced antibody; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1 antibody; Signal transducer and activator of transcription 6, interleukin 4 induced antibody; STAT 6 antibody; STAT interleukin4 induced antibody; STAT, interleukin4 induced antibody; Stat6 antibody; STAT6_HUMAN antibody; STAT6B antibody; STAT6C antibody; Transcription factor IL 4 STAT antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Signal transducer and activator of transcription 6 protein (1-319AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Alternatively activated macrophages are associated with the α2AP production that occurs with the development of dermal fibrosis. Y Kanno,Arthritis Research & Therapy volume,2020

Applications: Western Blot
Sample type: mice
Review: The expression of each protein in the skin from mice was examined by a Western blot analysis. The histogram shows quantitative representations of each protein. We showed that the administration of IL-4Rα neutralization antibodies to the bleomycin-treated mice attenuated the STAT6 activation in the skin.
PMID: 32272967

Target Data

Function Carries out a dual function
Gene References into Functions
  1. is a dependable marker to differentiate solitary fibrous tumors and myofibromas PMID: 28689369
  2. Inhibition of STAT6/Anoctamin-1 activation decreased proliferation, migration, or invasion of gastric cancer cells. PMID: 29466035
  3. Results of our structure-function studies on STAT6 shed light on mechanism of DNA recognition by STATs in general and explain the reasons underlying STAT6's preference for N4 site DNA over N3. PMID: 27803324
  4. There was no significant relationship between rs324011 and rs3024974 SNPs and psoriasis in the present study or in other studies, indicating that STAT6 is not a candidate gene for psoriasis susceptibility PMID: 28420002
  5. these results showed that allergy responses further accelerated the IL-4-induced inhibition of tumor development through the activation of STAT6 pathways. PMID: 28587956
  6. In this study, significant lower level of miR-214-3p and higher level of STAT6 in the intestinal mucosa of active UC patients compared with the health controls were confirmed by quantitative real-time PCR. PMID: 28752100
  7. IL-13, IL-13Ralpha1, STAT6 and ZEB1 have roles in promoting epithelial-mesenchymal transition and aggressiveness of colorectal cancer cells PMID: 27533463
  8. N4 DNA recognition by STAT6: structural and functional implications. PMID: 28220394
  9. Data suggest that STAT6 and RANKL are involved in regulation of apoptosis, gene expression, and cell proliferation in hepatocellular carcinoma cell lines; depletion of STAT6 using RNA interference increases apoptosis; this mechanism involves down-regulation of expression of RANKL. (STAT6 = signal transducer and activator of transcription 6; RANKL = receptor activator of nuclear factor kappa B ligand) PMID: 28525794
  10. The results showed that SARS coronavirus papain-like protease (PLPro) stimulated TGF-beta1-dependent expression of Type I collagen via activating STAT6 pathway. PMID: 28414040
  11. High STAT6 expression is associated with melanoma. PMID: 26993600
  12. Report a variant of t(14;18) negative nodal diffuse follicular lymphoma with CD23 expression, 1p36/TNFRSF14 abnormalities, and STAT6 mutations. PMID: 26965583
  13. Our data indicate that hypoxic inhibition of JMJD3 activity reduces demethylation of H3K27me3, nucleosome removal, and hence induction of the STAT6 target gene CCL18, while induction of other STAT6-inducible genes such as SPINT2 remained unaffected by JMJD3. PMID: 27737800
  14. The results suggest that nuclear localization and cleavage of STAT6 is important for modulating the viral latency and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). PMID: 28099521
  15. PVT1-derived miR-1207-5p promotes the proliferation of breast cancer cells by targeting STAT6. PMID: 28235236
  16. STAT6 single-nucleotide polymorphism is associated with migraine. PMID: 27322543
  17. STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both Grave's disease patients and experimental autoimmune Graves' disease mice. PMID: 27906181
  18. Here, we demonstrate that pulmonary adenofibromas are neoplastic lesions harbouring NAB2-STAT6 fusion genes ,the molecular hallmark of solitary fibrous tumours. PMID: 28072477
  19. STAT6 and ALDH1 immunohistochemistry can be used in the differential diagnosis of solitary fibrous tumor versus prostate-specific stromal neoplasms. PMID: 27068523
  20. Our results represented that meningeal solitary fibrous tumor/hemangiopericytoma were in a single biological spectrum with NAB2-STAT6 gene fusion as was nonmeningeal solitary fibrous tumor PMID: 26927892
  21. STAT6-TMEM16A-ERK1/2 signal pathway and TMEM16A channel activity are required for the IL-13-induced TMEM16A mediated mucus production PMID: 27588910
  22. The detection of nuclear relocation of STAT6 with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 fusion and helps to discriminate SFTs from histological mimics. PMID: 24702701
  23. The role of Th2 cytokines (IL-4, IL-13) and STAT6 in Th1/Th2 imbalance. PMID: 26781462
  24. STAT6 gene (G2964) polymorphism may play a role in development of eczema among Saudi children PMID: 27018548
  25. Variants of the NAB2-STAT6 fusion gene are found in solitary fibrous tumors of the meninges. PMID: 27271270
  26. It is a diagnostic tumor marker for Papillary' solitary fibrous tumor/hemangiopericytoma. PMID: 26746203
  27. nuclear immunohistochemistry staining can be used as a diagnostic criteria for unconventional fat-forming solitary fibrous tumors PMID: 25517867
  28. the majority of intrathoracic SFTs exhibited STAT6 nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type. PMID: 26686340
  29. Case Report: NAB2-STAT6 fusion in glioblastoma. PMID: 26817999
  30. A constitutively activated form of STAT6 is able to bypass IL-4 upstream signalling and instruct dendritic-cell-specific functional DNA methylation changes PMID: 26758199
  31. interleukin-4 regulates hematopoietic lineage choice by activating the JAK3-STAT6 pathway, which causes dendritic-cell-specific DNA demethylation PMID: 26829670
  32. Immunohistochemistry results indicate that combination with ALDH1 and STAT6 can improve the diagnostic value of CD34 for solitary fibrous tumors. PMID: 26617768
  33. T allele of rs324011 in STAT6 would increase the risk of atopic dermatitis (AD) occurrence in children. Haplotypes of rs324011/rs167769 were also significantly associated with childhood AD in Taiwanese population. PMID: 26048407
  34. We delineate the common and rare NAB2-STAT6 fusion variants in solitary fibrous tumors PMID: 26226844
  35. STAT6 is a direct target of miR-361-5p and promotes Bcl-xL expression. PMID: 26461141
  36. This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 nuclear expression and NAB2-STAT6 fusion similar to their soft tissue counterparts. PMID: 26883114
  37. It is associated with local recurrence and late distance metastasis of brain tumors to extracranial sites. PMID: 25893823
  38. bovine milk activates STAT6 in a p44/42 and p38-dependent manner in skin cells PMID: 26134630
  39. IL13Ralpha2 knockdown and IL-13 treatment cooperatively upregulated the metastasis suppressor tumor protein 63 (TP63) in a STAT6-dependent manner. PMID: 26208975
  40. Igepsilon gene transcription is regulated by histone modifications in the IL-4/STAT6 pathway. PMID: 25952120
  41. Solitary fibrous tumor occurring in the ocular adnexa (OA) as orbital mass with proptosis. In the OA, solitary fibrous tumor demonstrates STAT6 nuclear expression. PMID: 25761539
  42. Immunostaining and semiquantitative analysis revealed increased presence of phosphor-STAT6 in the pulmonary vasculature of patients with connective tissue disease-associated PAH and Schistosoma-PAH compared with normal control subjects. PMID: 26192556
  43. IL-13/STAT6 signaling is modulated by Kaposi's sarcoma-associated herpesvirus to promote host cell proliferation and viral pathogenesis. PMID: 26246572
  44. Eosinophilic esophagitis was associate with increased expression of STAT6. PMID: 25407941
  45. This study validated the existence of the NAB2-STAT6 fusion gene in solitary fibrous tumors and examined its relation with pathological features. PMID: 25554652
  46. also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17 PMID: 26136329
  47. results show that Cbl-b suppresses human ORMDL3 expression through STAT6 PMID: 26112603
  48. TRAIL induces RANKL expression through a STAT-6 dependent transcriptional regulatory mechanism in bone marrow stromal/preosteoblast cells. PMID: 25445452
  49. Strong nuclear STAT6 is largely specific for solitary fibrous tumors (SFTs). Physiologic low-level cytoplasmic/nuclear expression is common in mesenchymal neoplasia and is of uncertain significance. PMID: 25873501
  50. There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201). PMID: 25582503
  51. We further demonstrated that STAT6 silencing elicited ER stress-mediated apoptosis in NCI-H460 cells through C/EBP homologous protein (CHOP) induction, alteration of BH3 only proteins expression and ROS production. PMID: 25451482
  52. The ANO1 promoter region contains putative binding sites for multiple transcription factors including signal transducer and activator of transcription 6 (STAT6), a downstream effector of IL-4. PMID: 25351986
  53. Taken together, these findings indicate that inhibiting IL-4-induced eotaxin-1 expression by synephrine occurs primarily through the suppression of eosinophil recruitment, which is mediated by inhibiting STAT6 phosphorylation. PMID: 25111027
  54. reverse transcriptase PCR analysis identified a nerve growth factor inducible-A binding protein 2-STAT6 gene fusion. Our case supports the utility of STAT6 immunohistochemistry as an adjunct in the diagnosis of soft-tissue SFT with loss of CD34 positivity PMID: 25667482
  55. Short GT repeats of rs71802646 in STAT6 contribute to higher risk for asthma, while rs324015 may have a protective effect on atopic asthma. PMID: 24952213
  56. The STAT6 rs324011 homozygous T/T genotype was significantly associated with asthma risk in a Saudi Arabian population. PMID: 24912007
  57. The genetic and functional data combined strengthen the recognition of the IL-4/JAK/STAT6 axis as a driver of FL pathogenesis. PMID: 25428220
  58. Upregulation of IL-9 induced by pSTAT6 may be involved in the pathogenesis of chronic lymphocytic leukemia. PMID: 24966942
  59. In conclusion, STAT6 is amplified in a subset of dedifferentiated liposarcoma, resulting in STAT6 protein expression that can be detected by immunohistochemistry. PMID: 24457460
  60. We found that Stat6 interacts with progesterone-activated PR in T47D cells. Stat6 synergizes with progesterone-bound PR to transactivate the p21 and p27 gene promoters at the proximal Sp1-binding sites. PMID: 24401087
  61. Collectively, these studies demonstrated that Mycoplasma pneumoniae induces airway mucus hypersecretion by modulating the STAT/EGFR-FOXA2 signaling pathways. PMID: 25287927
  62. The anti-apoptotic phenotype of chronic lymphocytic leukemia involves a sensitized response for IL4 dependent STAT6 phosphorylation, and an activation of NF-kB signaling due to an increased affinity of sCD40L to its receptor. PMID: 24828787
  63. Tumors with the most common fusion variant, NAB2ex4-STAT6ex2/3, corresponded to classic pleuropulmonary solitary fibrous tumors with diffuse fibrosis and mostly benign behavior and occurred in older patients PMID: 24513261
  64. Gene silencing of IFN-gamma R2 leads to down-regulation of STAT-6 and phosphorylation-STAT-6 expressions, so gene silencing of STAT-6 results in the reduction of HeLa cell programmed death. PMID: 24674464
  65. is a highly sensitive and almost perfectly specific immunohistochemical marker for SFT and can be helpful to distinguish solitary fibrous tumor from histologic mimics. PMID: 24030747
  66. These data show that IL-4 and IL-13 decrease kinin receptors in a STAT6-dependent mechanism, which can be one important mechanism by which these cytokines exert their anti-inflammatory effects and impair bone resorption PMID: 23351078
  67. Data show that STAT6 and NF-kappaB are central players in mediating IL-31 expression induced by IL-4/IL-33. PMID: 24943220
  68. The combination of NCOA2 FISH and Stat6 IHC proved effective for the differential diagnosis of soft-tissue angiofibroma, even when using small biopsy specimens. PMID: 24856853
  69. These results suggest that IL-4Ralpha locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation. PMID: 24960198
  70. activation of the IL-4/STAT6 signaling pathway has a crucial role in aberrant glycosylation of IgA1 secretion, which is mediated by HIPK2 PMID: 24107646
  71. Dtat shows that pSTAT6 is sufficient to transcriptionally repress BCL6. PMID: 23852366
  72. nuclear STAT6 immunoreactivity is a highly sensitive and specific marker of solitary fibrous tumors PMID: 24625420
  73. Two STAT6 polymorphisms were associated with altered immune responses already at birth. STAT6 rs324011 was associated with lower neonatal Treg and increased Th1 response. PMID: 24053457
  74. Data indicate that signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. PMID: 24491557
  75. STAT6 polymorphisms and their combinations have an important influence on IgE level and development of asthma PMID: 23752766
  76. 44 SFTs were studied to identify pathogenetically important genetic rearrangements. RT-PCR analysis identified a NAB2/STAT6 fusion in 37/41 cases. PMID: 23761323
  77. STAT6 G2964A polymorphism does not have an association with the susceptibility to asthma. PMID: 23861779
  78. TLR3-induced placental miR-210 down-regulates the STAT6/interleukin-4 pathway, and this may contribute to the development of preeclampsia. PMID: 23844087
  79. IL-4 induces cellular senescence through independent signaling pathways involving STAT6 and p38 MAPK in some human renal cell carcinoma cell lines. PMID: 23935100
  80. influence of paternal origin of the STAT6 haplotype on IgE levels in asthma PMID: 22660217
  81. STAT6 polymorphisms might influence the therapeutic outcomes of patients infected with HCV-1 under standard-of-care (SOC) treatment. PMID: 23651608
  82. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion PMID: 23575898
  83. The interaction term [IL13 (rs20541) x STAT6 (rs1059513)] was statistically significant in both studies. PMID: 23815671
  84. patients' sera inhibited STAT6 phosphorylation induced by IL4 binding to CD124, demonstrating that these autoantibodies are functional and suggesting that IL4 neutralization has a pathogenetic role in Autoimmune hepatitis. PMID: 22997428
  85. The study indicated that the STAT6 promoter polymorphism rs3024944 was associated with uncomplicated malaria, whereas the FOXP3 promoter variant rs11091253 was associated with significant Plasmodium falciparum parasitaemia levels. PMID: 23297791
  86. STAT6 plays important roles in regulating the expression of human ORMDL3 by directly binding to the promoter region. PMID: 23461825
  87. PPIs, in concentrations achieved in blood with conventional dosing, significantly inhibit IL-4-stimulated eotaxin-3 expression in EoE esophageal cells and block STAT6 binding to the promoter. PMID: 23185525
  88. The results suggest that sIgE levels and STAT6 gene variants may be important determinants for development of tolerance to cows milke allergy. PMID: 23535094
  89. A gene fusion of the transcriptional repressor NAB2 with the transcriptional activator STAT6 is the defining driver mutation of solitary fibrous tumor. PMID: 23313952
  90. A NAB2-STAT6 fusion is a distinct molecular feature of solitary fibrous tumors. PMID: 23313954
  91. STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children. PMID: 22534531
  92. Dysregulation of Th1 transcription may contribute to heightened expression of STAT6 and GATA3 leading to exaggerated Th2-driven manifestations of allergic disease. PMID: 22909160
  93. the STAT6 phosphorylation/activation induced by IL-13 is mediated by an activation of JAK1 in cultured human bronchial smooth muscle cells. PMID: 22661199
  94. A shift from predominant immune cell Stat6 activation to Stat3 activation accompanies the onset of dysplasia with concomitant increased epithelial cell Stat3 activation. PMID: 22021169
  95. STAT6 in2SNP3 is associated with penicillin allergy, but has no effect on the specific IgE levels of patients with penicillin allergy. PMID: 22578203
  96. JAK1 and STAT6 may be universal mediators of IL-4 in the suppression of prostaglandin production in human follicular denritic cells. PMID: 22406175
  97. Toxoplasma gondii induces SERPIN B3/B4 expression via STAT6 activation to inhibit the apoptosis of infected cells for survival of the parasites. PMID: 22451727
  98. Small interfering RNA against transcription factor STAT6 leads to increased cholesterol synthesis in lung cancer cell lines PMID: 22162773
  99. Chinese children differed in polymorphisms of STAT6 and in its relation with childhood asthma. PMID: 22365404
  100. Pretreated CCD-11Lu cells with noncytotoxic doses (0.1-10 muM) of CAPE inhibited the production of eotaxin under stimulation of IL-4 and tnf-alpha.CAPE pretreatment decreased the amount of pSTAT6 and STAT6 DNA binding complexes in nuclear extracts. PMID: 21601544

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Subcellular Location Cytoplasm, Nucleus
Protein Families Transcription factor STAT family
Database Links

HGNC: 11368

OMIM: 601512

KEGG: hsa:6778

STRING: 9606.ENSP00000300134

UniGene: Hs.524518

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