STAT6, signal transducer and activator of transcription 6, is a transcription factor encoded by the STAT6 gene, which plays a role mainly in the immune system.The mechanism of action of STAT6 is activated by phosphorylation of Janus kinase (JAK) through binding to the receptor for cytokines such as IL-4 and IL-13, which in turn form homo- or heterodimers and translocate to the nucleus, regulating the expression of specific genes. It regulates the expression of specific genes. The signalling pathway involves the JAK/STAT6 pathway, which plays an important role in regulating the Th2-type immune response, promoting IgE production by B cells, and influencing cell proliferation and differentiation. Biologically, STAT6 is essential for the maintenance of immune homeostasis and is involved in inflammatory responses and anti-parasite immunity, etc. Abnormal activation of STAT6 has been associated with a variety of diseases, including allergic diseases such as asthma, and some types of cancer.
STAT6 Recombinant Monoclonal Antibody (CSB-RA988543A0HU)
Validated Data
Western Blot
Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate, K562 whole cell lysate
All lanes: STAT6 Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 95, 75, 82 kDa
Observed band size: 100 kDa
IHC image of CSB-RA988543A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
The following STAT6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
STAT6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA022816GA01HU | STAT6 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA073316 | Phospho-STAT6 (Tyr641) Antibody | Human | ELISA,WB,IHC |
CSB-PA204581 | Phospho-STAT6 (Thr645) Antibody | Human | ELISA,WB,IHC |
CSB-PA904385 | STAT6 (Ab-641) Antibody | Human | ELISA,WB,IHC |
CSB-PA596879 | STAT6 (Ab-645) Antibody | Human | ELISA,WB,IHC |
CSB-PA000624 | Phospho-STAT6 (T645) Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
CSB-PA000625 | Phospho-STAT6 (Y641) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA004183 | STAT6 Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
CSB-PA050171 | STAT6 Antibody | Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
CSB-PA138665 | STAT6 Antibody | Human,Mouse | ELISA,WB |
CSB-PA171110 | STAT6 Antibody | Human,Mouse | ELISA,WB |
CSB-PA022816LA01HU | STAT6 Antibody | Human | ELISA, IHC, IF |
CSB-PA022816LB01HU | STAT6 Antibody, HRP conjugated | Human | ELISA |
CSB-PA022816LC01HU | STAT6 Antibody, FITC conjugated | Human | |
CSB-PA022816LD01HU | STAT6 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA988543A0HU | STAT6 Recombinant Monoclonal Antibody | Human, Mouse | ELISA, WB, IHC |
STAT6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP022816HU CSB-EP022816HU CSB-BP022816HU CSB-MP022816HU CSB-EP022816HU-B |
Recombinant Human Signal transducer and activator of transcription 6 (STAT6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
STAT6 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP022816MO CSB-EP022816MO CSB-BP022816MO CSB-MP022816MO CSB-EP022816MO-B |
Recombinant Mouse Signal transducer and transcription activator 6 (Stat6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |