TBPL1 Antibody

Datasheet

Code	CSB-PA023240LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA023240LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TBPL1 Polyclonal antibody

Uniprot No.

P62380

Target Names

TBPL1

Alternative Names

21 kDa TBP-like protein antibody; 21kDa TBP like protein antibody; Second TBP of unique DNA antibody; Second TBP of unique DNA protein antibody; STUD antibody; TATA box binding protein like protein 1 antibody; TATA box binding protein-related factor 2 antibody; TATA box-binding protein-like protein 1 antibody; TATA box-binding protein-related factor 2 antibody; TBP like 1 antibody; TBP like protein antibody; TBP related factor 2 antibody; TBP-like factor antibody; TBP-like protein 1 antibody; TBP-related factor 2 antibody; TBP-related protein antibody; tbpl1 antibody; TBPL1_HUMAN antibody; TLF antibody; TLP antibody; TRF2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human TATA box-binding protein-like protein 1 protein (1-185AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TBPL1 Antibody (Product code: CSB-PA023240LA01HU) is Non-conjugated. For TBPL1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA023240LB01HU	TBPL1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA023240LC01HU	TBPL1 Antibody, FITC conjugated
Biotin	CSB-PA023240LD01HU	TBPL1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes. Seems to also mediate the transcription of NF1. Does not bind the TATA box.

Gene References into Functions

TLP Prevents p53 Degradation through Disrupting the p53-MDM2 Interaction. PMID: 28082682
The interaction of TBP-like protein with TFIIA is essential to suppress proteasome-dependent turnover of TBP-like protein PMID: 27696626
miR18a exhibits a protective role in colorectal cancer (CRC) via inhibiting proliferation, invasion and migration of CRC cells by directly targeting the TBPL1 gene. PMID: 26398009
results suggest that activation of the p21 upstream promoter is mediated by interaction between specific regions of TLP and p53 PMID: 24594805
Western blotting and immunohistochemistry both indicated a higher TBPL1 protein expression level in colorectal cancer tissue. siRNA for TBPL1 transfection obviously slowed down the cell proliferation in both SW-620 and HT-29 cells. PMID: 24870791
TLP mediates p53-governed transcriptional activation of the p21 upstream promoter. PMID: 22511763
Data show that during interphase, endogenous or exogenously expressed TRF2 is located almost exclusively in the nucleolus PMID: 15269281
TLF is a functional regulator of transcription with targets distinct from those of TBP. PMID: 15767669

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

TBP family

Tissue Specificity

Ubiquitously expressed, with highest levels in the testis and ovary.

Database Links

HGNC: 11589

OMIM: 605521

KEGG: hsa:9519

STRING: 9606.ENSP00000237264

UniGene: Hs.486507

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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