TIPARP Antibody, Biotin conjugated

Code CSB-PA801800LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TIPARP Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
ADP-ribosyltransferase diphtheria toxin-like 14 antibody; ARTD14 antibody; AW558171 antibody; DDF1 antibody; DKFZp434J214 antibody; DKFZp686N0351 antibody; DKFZp686P1838 antibody; FLJ40466 antibody; PARP 1 antibody; PARP 7 antibody; PARP-7 antibody; PARPT_HUMAN antibody; pART14 antibody; Poly [ADP ribose] polymerase 7 antibody; Poly [ADP-ribose] polymerase 7 antibody; TCDD inducible poly(ADP ribose) polymerase antibody; TCDD-inducible poly [ADP-ribose] polymerase antibody; TIPARP antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TCDD-inducible poly [ADP-ribose] polymerase protein (74-178AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins. Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR.
Gene References into Functions
  1. TIPARP is a viral RNA-sensing pattern recognition receptors that mediates antiviral responses triggered by BAX- and BAK1-dependent mitochondrial damage PMID: 28213497
  2. Moreover, time course and promoter activity assays suggest that TIPARP and TIPARP-AS1 work in concert to regulate AHR signaling. Collectively, these data show an added level of complexity in the AHR signaling cascade which involves lncRNAs, whose functions remain poorly understood. PMID: 29274782
  3. Knockdown of TiPARP, but not AHRR, increased 2,3,7,8-tetrachlorodibenzo-p-dioxin - induced CYP1A1 mRNA and AHR protein levels. PMID: 24806346
  4. Single nucleotide polymorphism in TIPARP is associated with ovarian cancer. PMID: 20852632
  5. TIPARP (DKFZp434J214) gene is amplified in HNSCC. TIPARP, FLJ22693 and ZAP proteins with TPH, WW and PARP-like domains constitute the TIPARP family. PMID: 12851707

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Subcellular Location
Nucleus.
Database Links

HGNC: 23696

OMIM: 612480

KEGG: hsa:25976

STRING: 9606.ENSP00000295924

UniGene: Hs.744050

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