TLN2 Antibody

Code CSB-PA897282HA01HU
Size US$166
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  • Western blot
    All lanes: TLN2 antibody at 12μg/ml
    Lane 1: Hela whole cell lysate
    Lane 2: Jurkat whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 272 kDa
    Observed band size: 230 kDa

  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA897282HA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA897282HA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TLN2 Polyclonal antibody
Uniprot No.
Target Names
TLN2
Alternative Names
DKFZp451B1011 antibody; DKFZp686I0976 antibody; DKFZp686K0979 antibody; ILWEQ antibody; KIAA0320 antibody; Talin-2 antibody; talin2 antibody; TLN 2 antibody; TLN2 antibody; TLN2_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Talin-2 protein (88-406AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TLN2 Antibody (Product code: CSB-PA897282HA01HU) is Non-conjugated. For TLN2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA897282HB01HU TLN2 Antibody, HRP conjugated ELISA
FITC CSB-PA897282HC01HU TLN2 Antibody, FITC conjugated
Biotin CSB-PA897282HD01HU TLN2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity.
Gene References into Functions
  1. The central role of talin and vinculin in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM interactions and remodeling of the tissue. PMID: 27816808
  2. These results suggest that a strong interaction of talin2 with integrins is required to generate traction, which in turn drives invadopodium-mediated matrix degradation, which is key to cancer cell invasion. PMID: 27694340
  3. data suggest a potential molecular link between TLN2 and camptodactyly pathogenesis. PMID: 27223613
  4. Both TLN-1 and TLN-2 levels correlate with tumorigenicity in human HCC, indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma . PMID: 26822056
  5. Data indicate the role of vinculin in inducing the talin mediated integrin activation. PMID: 24446374
  6. Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload. PMID: 23266827
  7. Data show that SCGB3A1 was down-regulated in invasive compared with DCIS, whereas talin 2 (TLN2) and PTGS1 were up-regulated in invasive compared with DCIS. PMID: 21812955
  8. This review discusses the general function of talin 1 and talin 2, as well as vinculin/metavinulin, with emphasis on what is understood about their role in the cardiac myocyte and in whole heart. PMID: 19952892
  9. Structural diversity in integrin/talin interactions. PMID: 21134644
  10. the differential concentration of CSF and serum-talin 2 in the drug-refractory postencephalitic epilepsy group is an intractability-related phenomenon that might be involved in the development of RPEE PMID: 20620133
  11. we show that the predominant brain splice variant of PtdInsPKI gamma (PtdInsPKI gamma-90) binds, by means of a short carboxy-terminal peptide, to the FERM domain of talin, and is strongly activated by this interaction PMID: 12422219
  12. The F-actin binding capacity of Talin 2 is regulated by intrasteric occlusion of primary actin-binding determinants within the talin I/LWEQ module. PMID: 15581353
  13. Talin2 may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated muscle. PMID: 17183545
  14. Data show that TLN2n presents only in the CSF of temporal lobe epilepsy patients. PMID: 19109932

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Subcellular Location
Cytoplasm. Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.
Database Links

HGNC: 15447

OMIM: 607349

KEGG: hsa:83660

STRING: 9606.ENSP00000303476

UniGene: Hs.569438

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