TNNI3 Antibody, HRP conjugated

Code CSB-PA07939B0Rb
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) TNNI3 Polyclonal antibody
Uniprot No. P19429
Target Names TNNI3
Alternative Names cardiac muscle antibody; Cardiac troponin I antibody; cardiomyopathy; dilated 2A (autosomal recessive) antibody; Cardiomyopathy; familial hypertrophic; 7; included antibody; CMD1FF antibody; CMD2A antibody; CMH7 antibody; cTnI antibody; Familial hypertrophic cardiomyopathy 7 antibody; MGC116817 antibody; RCM1 antibody; Tn1 antibody; Tni antibody; TNN I3 antibody; TNNC 1 antibody; TNNC1 antibody; TNNI3 antibody; TNNI3_HUMAN antibody; Troponin I antibody; Troponin I cardiac antibody; Troponin I cardiac muscle antibody; Troponin I cardiac muscle isoform antibody; Troponin I type 3 cardiac antibody; troponin I; cardiac 3 antibody; TroponinI antibody; Ttroponin I type 3 (cardiac) antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Troponin I, cardiac muscle protein (2-210AA)
Immunogen Species Homo sapiens (Human)
Conjugate HRP
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Tested Applications ELISA
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Gene References into Functions
  1. Data show that the incident atrial fibrillation (AF) occurrence group had similar baseline troponin I (TnI) levels, but higher troponin T (TnT) levels [Review and Meta-Analysis]. PMID: 29631448
  2. Studies indicate that in patients with end-stage renal disease (ESRD), elevation of cardiac-specific troponin T (cTnT) was more frequent than elevation of troponin I (cTnI) [Review]. PMID: 28545334
  3. the frequency of h-FABP positivity among acute myocardial infarction patients was higher than that of hs-TnI, which would have missed six of them; however, hs-TnI area under curve was superior to that of h-FABP. PMID: 28650717
  4. Reversible Covalent Reaction of Levosimendan with Cardiac Troponin C in Vitro and in Situ. PMID: 29558109
  5. The QT interval has a strong positive linear correlation with cardiac troponin-I levels in Non-ST-elevation myocardial infarction. PMID: 28366473
  6. Apelin-12 influences troponin I levels in the acute phase of STEMI, whereas during the non-acute phase, low apelin levels were associated with a high rate of MACE. PMID: 28728608
  7. In clinical stable patients without known cardiovascular disease, a thorough chest-pain history in combination with hs-TnI testing can identify a significant low-risk group. PMID: 28031149
  8. Study showed that in patients who underwent liver transplantation elevation of preoperative high-sensitivity cardiac troponin I level was associated with 1-year mortality and 30-day mortality. PMID: 28542299
  9. Serial measurement of troponin I revealed a persistent elevation in patients with diabetes mellitus type 2. PMID: 28246236
  10. Plasma troponin C1 (cTnI) is biomarker of choice for diagnosing acute myocardial infarction (AMI) because of its high specificity as biomarker for damage to myocardial tissue. Data suggest the "best cut-off" for plasma cTnI is 0.014 micrograms/L in AMI. These studies were conducted in emergency department of a university hospital in Italy using point-of-care testing in patients presenting with chest pain, ages 18-101. PMID: 28377153
  11. NT-proBNP and hs-cTnI levels were higher in systemic sclerosis patients than controls. Both NT-proBNP and hs-cTnI were associated with the presence of echocardiographic abnormalities. PMID: 27601074
  12. value of cTnI level assessed 24 hours post-surgery was a reliable predictor of death following liver transplantation with optimal cut-off value of 0.215 ng/mL. The surgery time was the most important predictor of cTnI elevation. PMID: 28455997
  13. cTnI levels are common in Fabry disease patients, reflecting cardiac involvement. PMID: 27322070
  14. Report novel troponin I rule-out value below the upper reference limit for acute myocardial infarction. PMID: 27067356
  15. cTnI determined in hemodynamically stable patients with suspected AMI and wide QRS complex using optimized diagnostic thresholds improves rule-in and rule-out with respect to presence of a significant obstructive CAD PMID: 27148734
  16. 83 preterm infants with Bronchopulmonary dysplasia born <28-wk gestation and still inpatients at 36-wk corrected age received an echocardiogram and blood tests of B-type natriuretic peptide (BNP), troponin I, and YKL-40. PMID: 27760764
  17. Serum cardiac troponin I was increased in septic patients with myocardial depression compared to those without myocardial depression. PMID: 27238916
  18. Elevated BNP and hs-cTnI after kidney transplantation identify candidates for targeted risk reduction. PMID: 26910333
  19. These perturbed biophysical and biochemical myofilament properties are likely to significantly contribute to the diastolic cardiac pump dysfunction that is seen in patients suffering from a restrictive cardiomyopathy that is associated with the cTnI R145W mutation. PMID: 27557662
  20. epigenetic modification caused cTnI expression decrease is one of the possible causes that result in a reduced cTnI level and diastolic dysfunction in older mouse hearts PMID: 27184165
  21. Among hospitalized patients with cardiac troponin I values above 30 ng/L, the majority will have myocardial injury. Cardiac nonischemic conditions are associated with very high troponin concentrations, but the outcome is rather good. In contrast, myocardial injury related to noncardiac or multiple conditions carries a very poor long-term prognosis. PMID: 26763756
  22. troponin I carboxy terminal mobile domain and linker sequence has a role in regulating cardiac contraction PMID: 26971468
  23. the last 5 C-terminal residues of cTnI influence the binding of cTnI with cTnC and cTnT and affect the Ca(2+) dependence of filament sliding PMID: 26919894
  24. Study found that N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I are independently associated with incident dementia and NT-proBNP with incident Alzheimer's disease PMID: 28039523
  25. The clones were selected using microtiter plate coated with human cardiac troponin I (hcTnI). Product of hybridoma cells that bind with high affinity to human cardiac troponin I were selected PMID: 27556913
  26. Sex, age, and systolic blood pressure belong to the strongest determinants of hs-cTnI in healthy adults. PMID: 27535138
  27. This review summarizes the recent proteomic data on aminoacid sequences of cTnT and cTnI in various species, as well as selected analytical characteristics of human cardiac troponin high-sensitivity assays PMID: 26876101
  28. In stable coronary artery disease patients successfully treated with PCI, pre-procedural cTnI levels, in the upper limits of the normal range, are associated with hard cardiac endpoints. PMID: 25405803
  29. Calcium channel blockers and adrenergic beta antagonists reduced hs-TnI levels significantly both at rest and during exercise in atrial fibrillation patients/. PMID: 27142292
  30. Compromised interactions of K206I with actin and hcTnC may lead to impaired relaxation and HCM. PMID: 26553696
  31. hsTnI at the time of presentation followed by early advanced coronary CTA assessment improves the risk stratification and diagnostic accuracy for acute coronary syndromes. PMID: 26476506
  32. These findings showed that a double heterozygous mutation in the TNNI3 gene is involved in the pathogenesis of hypertrophic cardiomyopathy via haploinsufficiency. PMID: 26506446
  33. The incidence of adverse cardiovascular events was significantly higher in patients with troponin elevation after carotid endarterectomy, which was mainly attributable to silent non-ST segment elevation MIs that occurred in the early post-operative phase. PMID: 26553374
  34. Four novel missense variants were identified in TNNI3. PMID: 26169204
  35. Letter/Case Report: acute decompensated heart failure with troponin I elevation in hereditary hemochromatosis. PMID: 25916738
  36. In this pilot study, the addition of CACS to hsTnI improves the identification of low-risk subjects in whom CTA might be avoided. PMID: 26049777
  37. Exclusion of acute myocardial infarction 2h after presentation in emergency patients with possible acute coronary syndrome can be achieved using hs-cTnT or hs-cTnI assays. PMID: 24316100
  38. Hybrid coronary revascularization is associated with lower postoperative cTn release, compared with off-pump coronary artery bypass surgery. PMID: 25217621
  39. Carotid endarterectomy is followed by a high incidence of asymptomatic cTnI increase that is associated with late cardiac events. PMID: 25601178
  40. mutations underlying restrictive cardiomyopathy all marked by right-sided cardiac manifestations in South African patients PMID: 25940119
  41. Circulating levels of sensitive cTnI and NT-proBNP are related to LV function and infarct size in patients with stable CAD after revascularization. PMID: 25788439
  42. Serum TnI detected significant myocardial necrosis in a majority of patients with chronic HF due to LVSD and when measured serially, provided independent risk information for poor CV outcomes and deleterious LV remodeling. PMID: 25777344
  43. The elevation of Tn I after PCI in patients with normal initial level is more significant predictor of early (30-day) mortality compared to later (within 12 months) mortality. PMID: 25617100
  44. AF patients both without and with CAD showed similar cTnI concentrations at admission. A second validation of cTnI is mandatory for all patients. PMID: 25653186
  45. cardiac troponin T or troponin I compared to creatine kinase in patients with revascularized acute myocardial infarction PMID: 25381953
  46. Even a single elevated Troponin I value increased the risk of myocardial infarction. PMID: 25195101
  47. Abbott high-sensitivity cardiac-TnI levels in a total of 3314 Korean patients with chest pain, were determined. PMID: 25887868
  48. Absolute delta performed significantly better than relative delta at all time intervals to measure changes in troponin I for early diagnosis of myocardial infarction. PMID: 25261587
  49. The high accordance with LGE, reflecting cardiac dysfunction, suggests that cTNI-elevation can be a useful laboratory parameter for assessing myocardial damage in FD. PMID: 24626231
  50. Using an overall 99th percentile for cTnI does not appear to increase the prevalence of myocardial injury or lead to further hospital admissions from the emergency department. PMID: 26185217
  51. CTnI level of > 0.25 mug L(-1) at presentation in patients with thrombotic thrombocytopenic purpura appears to be an independent factor associated with a three-fold increase in the risk of death or refractoriness. PMID: 25403270
  52. Plasma cTnI is detectable during long-term follow-up after heart transplantation and is associated with graft rejection. PMID: 25451703
  53. The functional integration of TnI phosphorylation may be a common mechanism to modulate Ser-23/24 phosphorylation function. PMID: 25252176
  54. hsTnI concentrations in the top tertile are associated with a 1st major cardiovascular event and all-cause mortality in a primary prevention cohort. Release may be due to myocardial cell necrosis, apoptosis, hemodynamic stress, or metabolic abnormalities. PMID: 25825410
  55. the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics PMID: 25296321
  56. cTnI levels were higher in ischemics compared with those without myocardial ischemia when pre- and post-ERCP periods were compared. PMID: 25141318
  57. Resting troponin I-NH2-terminal truncated cardiomyocytes had shorter length than wild-type cells with no change in sarcomere length. PMID: 25518962
  58. cTnI and cTnT concentrations are moderately correlated and measurable in plasma of most atrial fibrillation patients. The risk of stroke and cardiovascular events is highest when both troponins are above median concentrations. PMID: 25451868
  59. In this review, we will discuss classic and emerging biomarkers of cardiovascular disease and the role of these biomarkers in the diagnosis and prognosis of elderly patients. PMID: 25053882
  60. Further studies may reveal capability of salivary cTnI for being used for developing point-of-care testing for early detection of MI in pre-clinical settings. PMID: 24521627
  61. The levels of H-FABP, NT-proBNP, and cTnI were correlated with heart function, and can be used for the diagnosis of early-stageheart failure in children with congenital heart disease PMID: 24899611
  62. In adult Hypertrophic Cardiomyopathy patients, thin-filament gene TNNI3 mutations are associated with increased likelihood of advanced Left Ventricular dysfunction and heart failure compared with thick-filament disease. PMID: 25524337
  63. Development of pathological hypertrophy did not occur in mice expressing both Tm180 and TnI-PP. PMID: 24585742
  64. Troponin I levels were found to be a good biomarker to distinguish acute coronary syndrome from Takotsubo cardiomyopathy. PMID: 24794960
  65. Acute myocardial infarction was rapidly ruled out using undetectable levels of troponin I. PMID: 23876467
  66. Both absolute and relative changes in cardiac troponin I provided very high accuracy in the early diagnosis of acute myocardial infarction. PMID: 23910445
  67. There is a relationship between cTnI at the acute phase of acute myocardial infarction and extent of microvascular obstruction as assessed by 3-T cardiac MRI. PMID: 24886208
  68. Troponin I levels are often abnormal in atrial fibrillation patients. PMID: 24456881
  69. In clinically stable patients undergoing elective coronary artery bypass grafting, measurements of cTnI are useful in ruling out a type 5 myocardial infarction. PMID: 24468543
  70. Elevated high-sensitivity troponin-I in patients with diabetes mellitus type 2 is associated with increased cardiovascular mortality. PMID: 24661773
  71. Data indicate a high serum troponin I level after an acute episode of paroxysmal supraventricular tachycardia with normal coronary arteries via angiography. PMID: 24618063
  72. Cardiac TnI release is common before Norwood and BDG operations; then during the treatment protocol for hypoplastic left heart syndrome, cTnI release resolves. PMID: 24101702
  73. Cardiac troponin I blood levels were increased in runners and walkers dependent on exercise intensity. PMID: 24315342
  74. Familial hypertrophic cardiomyopathy mutants cTnI R145G and cTnT R278C were tested alone and together in motility assays. Sliding at low Ca2+ (diastolic dysfunction) with cTnI R145G is worsened by cTnT R278C. PMID: 24418317
  75. High troponin I levels are associated with epicardial coronary etiology for myocardial ischemia. PMID: 24383069
  76. Elevated TnI levels are independently associated with cardiac and all-cause mortality in asymptomatic hemodialysis patients. PMID: 24206774
  77. High-sensitive levels of troponin detected before pre-aortic valve transplantation predict survival following the procedure. PMID: 24063930
  78. Myocardial cTnI is an independent prognostic factor for cardiac outcomes in myocardial infarction. PMID: 24489430
  79. A structural study of troponin I mutations found in hypertrophic cardiomyopathy patients indicate that the mutations result in a decrease in protein stability and loss of important interactions between the three troponin subunits. PMID: 23967088
  80. Serum concentrations of cTnI but not CK-MB or myoglobin are an independent predictor of all-cause mortality in patients with IDC. PMID: 24794782
  81. A homozygous mutation in cardiac troponin I gene was found in a family with hypertrophic cardiomyopathy. PMID: 23270746
  82. Patients with brain injury following moderate head trauma have high levels of highly sensitive troponin I. PMID: 23398826
  83. Troponin I serial measurements are useful for determining damage to the heart in myasthenia gravis-related cardiomyopathy. PMID: 23886525
  84. Remote ischemic preconditioning does not contribute to exercise-induced increase in plasma troponin I. PMID: 23410486
  85. Elevations of cTnI not associated with ACS were common in patients with chronic kidney disease stage 3 to 5. PMID: 24660542
  86. Early increases in Troponin I levels are linked to increased risk of cardiotoxicity in breast cancer patients undergoing doxorubicin and trastuzumab therapy. PMID: 24291281
  87. Troponin I concentrations in healthy individuals are dependent on prevalent cardiovascular diseases and risk factors. PMID: 22560907
  88. In multivariable analysis, hs-TnI was significantly associated with stroke or systemic embolism, it was also significantly associated with cardiac death. PMID: 24226808
  89. Somatic mutations in MYH7, MYBPC3, TPM1, TNNT2, and TNNI3 do not represent an important etiologic pathway in HCM. PMID: 23782526
  90. Elevated serum cardiac troponin I values are seen in Friedreich ataxia. PMID: 22633670
  91. Cardiac troponin I levels are associated with thromboembolic risk in patients with atrial fibrillation. PMID: 22353438
  92. Persistence of troponin (Tn)I elevation in heart failure patients even at low levels is a worse survival indicator than recurrent TnI elevation, which portends a poor prognosis. PMID: 22119115
  93. Both highly sensitive and conventional TnI were increased in gynecological cancer patients. PMID: 23660299
  94. Conclude that dilated cardiomyopathy-causing mutations in thin filament proteins abolish the relationship between myofilament Ca(2+) sensitivity and troponin I phosphorylation by PKA. PMID: 23539503
  95. Higher plasma Troponin I levels in coronary artery disease patients are associated with higher plasma phosphorus and calcium levels, and lower vitamin D levels. PMID: 23552626
  96. cTnI release is more frequently associated with pressure than volume overload in children with congenital heart defects. PMID: 23163407
  97. TnI levels rise significantly during hemodialysis and a greater intra-dialysis rise in cTnI is associated with an increased incidence of cardiovascular events PMID: 23397594
  98. Report prognostic role of normal troponin values in diagnosis myocardial infarction. PMID: 23604180
  99. An elevated TnI in the context of acute liver injury or liver failure following paracetamol overdose is associated with a significantly worse patient outcome but it is not an independent prognostic factor. PMID: 23829708
  100. Our LFIA performance was additionally compared with electrochemiluminescence immunoassay (ECLI) detection for simultaneous determination of hs-cTnI and myoglobin in patients with suggestive of acute myocardial infarction . PMID: 23247055

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Involvement in disease Cardiomyopathy, familial hypertrophic 7 (CMH7); Cardiomyopathy, familial restrictive 1 (RCM1); Cardiomyopathy, dilated 2A (CMD2A); Cardiomyopathy, dilated 1FF (CMD1FF)
Protein Families Troponin I family
Database Links

HGNC: 11947

OMIM: 115210

KEGG: hsa:7137

STRING: 9606.ENSP00000341838

UniGene: Hs.709179

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