TNNI3

TNNI3 encodes cardiac troponin I (cTnI), a core component of the troponin complex in cardiac muscle fibers. Common aliases include troponin I cardiac isoform. It modulates muscle contraction by binding actin-tropomyosin to block myosin-actin interaction at rest; when calcium ions bind troponin C, cTnI undergoes a conformational shift, relieving this inhibition to allow contraction.
Pathogenic TNNI3 mutations are associated with hypertrophic, dilated, or restrictive cardiomyopathies. cTnI is a gold-standard biomarker for acute myocardial infarction, as its release into circulation indicates cardiac tissue damage. While direct targeted drugs are in preclinical stages, current management for TNNI3-related conditions includes beta-blockers and ACE inhibitors; gene editing approaches to correct pathogenic mutations are also under active research.

Validated Data

IHC image of CSB-RA448852A0HU diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

IHC image of CSB-RA448852A0HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

Human cardiac troponin Ⅰ,cTn-ⅠELISA Kit (CSB-E05139h)

Validated Data

Code: CSB-E05139h

Size: 96T,5×96T,10×96T

Sensitivity: 11.75 pg/mL

Detection Range: 47 pg/mL-3000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following TNNI3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TNNI3 Antibodies

TNNI3 Proteins

TNNI3 ELISA Kits

TNNI3 Antibodies

TNNI3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA07936A0Rb	TNNI3 Antibody	Human	ELISA
CSB-PA07936B0Rb	TNNI3 Antibody, HRP conjugated	Human	ELISA
CSB-PA07936D0Rb	TNNI3 Antibody, Biotin conjugated	Human	ELISA
CSB-PA948523	Phospho-TNNI3 (Thr142) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA182407	Phospho-TNNI3 (Ser43) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA004335	TNNI3 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA050276	Phospho-TNNI3 (T142) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA050277	Phospho-TNNI3 (S43) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA050278	TNNI3 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA119248	TNNI3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA133116	TNNI3 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA07939A0Rb	TNNI3 Antibody	Human, Rat	ELISA, IHC, IF, IP
CSB-PA07939B0Rb	TNNI3 Antibody, HRP conjugated	Human	ELISA
CSB-PA07939C0Rb	TNNI3 Antibody, FITC conjugated	Human
CSB-PA07939D0Rb	TNNI3 Antibody, Biotin conjugated	Human	ELISA
CSB-RA448852A0HU	TNNI3 Recombinant Monoclonal Antibody	Human	ELISA, IHC

TNNI3 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA006344	Phospho-TNNI3 (S22/S23) Antibody	Mouse,Rat	WB, IHC, ELISA
CSB-PA006356	TNNI3 Antibody	Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA341785LA01MO	Tnni3 Antibody	Mouse, Rat	ELISA, WB
CSB-PA341785LB01MO	Tnni3 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA341785LC01MO	Tnni3 Antibody, FITC conjugated	Mouse
CSB-PA341785LD01MO	Tnni3 Antibody, Biotin conjugated	Mouse	ELISA

TNNI3 Antibodies for Rattus norvegicus (Rat)

Code	Product Name	Species Reactivity	Application
CSB-PA006352	TNNI3 Antibody	Rat	WB, IF, ELISA

TNNI3 Proteins

TNNI3 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP024013CH CSB-EP024013CH CSB-BP024013CH CSB-MP024013CH CSB-EP024013CH-B	Recombinant Chicken Troponin I, cardiac muscle (TNNI3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Source
CSB-YP024013RB CSB-EP024013RB CSB-BP024013RB CSB-MP024013RB CSB-EP024013RB-B	Recombinant Rabbit Troponin I, cardiac muscle (TNNI3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP024013BO CSB-EP024013BO CSB-BP024013BO CSB-MP024013BO CSB-EP024013BO-B	Recombinant Bovine Troponin I, cardiac muscle (TNNI3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP340566RA CSB-EP340566RA CSB-BP340566RA CSB-MP340566RA CSB-EP340566RA-B	Recombinant Rat Troponin I, cardiac muscle (Tnni3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)

Code	Product Name	Source
CSB-YP340901DXJ CSB-EP340901DXJ CSB-BP340901DXJ CSB-MP340901DXJ CSB-EP340901DXJ-B	Recombinant Coturnix coturnix japonica Troponin I, cardiac muscle (TNNI3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP341785MO CSB-BP341785MO CSB-MP341785MO CSB-EP341785MO-B	Recombinant Mouse Troponin I, cardiac muscle (Tnni3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP341785MO	Recombinant Mouse Troponin I, cardiac muscle (Tnni3)	E.coli

TNNI3 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP342702XBE CSB-EP342702XBE CSB-BP342702XBE CSB-MP342702XBE CSB-EP342702XBE-B	Recombinant Xenopus laevis Troponin I, cardiac muscle (tnni3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Equus caballus (Horse)

Code	Product Name	Source
CSB-YP719026HO CSB-BP719026HO CSB-MP719026HO CSB-EP719026HO-B	Recombinant Horse Troponin I, cardiac muscle (TNNI3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Felis catus (Cat) (Felis silvestris catus)

Code	Product Name	Source
CSB-YP772925CA CSB-BP772925CA CSB-MP772925CA CSB-EP772925CA-B	Recombinant Cat Troponin I, cardiac muscle (TNNI3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP853992DO CSB-BP853992DO CSB-MP853992DO CSB-EP853992DO-B	Recombinant Dog Troponin I, cardiac muscle (TNNI3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TNNI3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP024013HU CSB-EP024013HU-B	Recombinant Human Troponin I, cardiac muscle (TNNI3)	Yeast In Vivo Biotinylation in E.coli

TNNI3 ELISA Kit

TNNI3 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Sample Types	Sensitivity
CSB-E08772c	Canine Cardiac Troponin Ⅰ(cTn-Ⅰ) ELISA kit	serum, plasma, tissue homogenates	5.8 pg/mL

TNNI3 ELISA Kit for Rattus norvegicus (Rat)

Code	Product Name	Sample Types	Sensitivity
CSB-E08594r	Rat Cardiac Troponin Ⅰ(cTn-Ⅰ) ELISA kit	serum, plasma, tissue homogenates	7.81 pg/mL

TNNI3 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E05139h	Human cardiac troponin Ⅰ,cTn-ⅠELISA Kit	serum, plasma, urine	11.75 pg/mL

TNNI3 ELISA Kit for Oryctolagus cuniculus (Rabbit)

Code	Product Name	Sample Types	Sensitivity
CSB-E11286Rb	Rabbit cardiac troponin Ⅰ,cTn-ⅠELISA Kit	serum, plasma, tissue homogenates	11.75 pg/mL

TNNI3 ELISA Kit for Mus musculus (Mouse)

Code	Product Name	Sample Types	Sensitivity
CSB-E08421m	Mouse cardiac troponin Ⅰ(cTn-Ⅰ) ELISA kit	serum, plasma	3.9 pg/mL

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily? Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application

TNNI3

Popular Product: