TRAC Antibody

Datasheet

Code	CSB-PA024144LA01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TRAC Polyclonal antibody

Uniprot No.

P01848

Target Names

TRAC

Alternative Names

TRAC antibody; TCRA antibody; T cell receptor alpha constant antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human T cell receptor alpha constant protein (1-140AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TRAC Antibody (Product code: CSB-PA024144LA01HU) is Non-conjugated. For TRAC Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA024144LB01HU	TRAC Antibody, HRP conjugated	ELISA
FITC	CSB-PA024144LC01HU	TRAC Antibody, FITC conjugated
Biotin	CSB-PA024144LD01HU	TRAC Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

CUSABIO's product CSB-PA024144LA01HU is a polyclonal antibody raised in rabbits against the recombinant human TRAC protein (1-140AA). It occurs as an unconjugated IgG. Its purity is greater than 95% using protein G purified. It only shows reactivity with human TRAC protein, a subunit chain of the T-cell receptor (TCR) that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules. This TRAC antibody is suitable for the detection of TRAC protein in ELISA analysis.

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Target Background

Function

Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.

Involvement in disease

Immunodeficiency 7 (IMD7)

Subcellular Location

Cell membrane.

Database Links

HGNC: 12029

OMIM: 186880

UniGene: Hs.74647

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