TRAF5 Antibody

Code CSB-PA024153ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA024153ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRAF5 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
MGC:39780 antibody; RING finger protein 84 antibody; RNF 84 antibody; RNF84 antibody; TNF receptor associated factor 5 antibody; TNF receptor-associated factor 5 antibody; TRAF 5 antibody; Traf5 antibody; TRAF5_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human TNF receptor-associated factor 5 protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Gene References into Functions
  1. High TRAF5 expression is associated with colorectal cancer. PMID: 29328486
  2. These findings indicate that miR-26b might influence TRAF5-MAPK signaling pathways to facilitate the malignant progression of melanoma cells. PMID: 26872428
  3. findings reveal a direct link between TRAF5-mediated ubiquitination and RORgammat protein regulation PMID: 26453305
  4. This study provides evidence that TRAF5 and TRAF3IP2 genes are involved in the development of Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome. PMID: 24416204
  5. Data indicate that TNF receptor-associated factor 5 (TRAF5) gene is involved in the development of acute anterior uveitis (AAU) and pediatric uveitis. PMID: 24020968
  6. TRAF3 and TRAF5 are overexpressed in inflammatory bowel disease PMID: 23329887
  7. Numbl interacted with tumor necrosis factor receptor-associated factor 5, which signals upstream and is required for the activation of NF-kappaB, and committed it to proteasomal degradation by promoting K48-linked polyubiquitination of TRAF5 PMID: 22593207
  8. Resutls indicate that TRAF5 may be a key molecule in the innate response against viral infection. PMID: 20161788
  9. TRAF5 has a role in TNF-alpha induced IKK phosphorylation of NF-kappaB p65 PMID: 12842894
  10. These findings provide evidence for the association of an SNP upstream of a strong candidate RA susceptibility gene, TRAF5. PMID: 17277003

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Subcellular Location
Cytoplasm. Cytoplasm, cytosol.
Protein Families
TNF receptor-associated factor family, A subfamily
Tissue Specificity
Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
Database Links

HGNC: 12035

OMIM: 602356

KEGG: hsa:7188

STRING: 9606.ENSP00000261464

UniGene: Hs.523930

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