TRAF5

TRAF5, or TNF receptor-associated factor 5, is a cytoplasmic adaptor protein involved in mediating signaling from TNF receptors and Toll-like receptors. It functions as a scaffold, recruiting downstream kinases like MEKK3 to activate NF-κB and MAPK pathways, thereby regulating immune responses and inflammation.
Aberrant TRAF5 activity is linked to autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Its role in B-cell activation also implicates it in lymphoma development. While no direct TRAF5-targeted drugs are approved, preclinical studies explore small-molecule inhibitors to modulate its scaffolding function in inflammatory disorders.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP024153HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TRAF5.

TRAF5 Antibody (CSB-PA146040)

Validated Data

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA146040(TRAF5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA146040(TRAF5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Jurkat cells, Primary antibody: CSB-PA146040(TRAF5 Antibody) at dilution 1/450, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds

The following TRAF5 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TRAF5 Antibodies

TRAF5 Proteins

TRAF5 Antibodies

TRAF5 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA024153GA01HU	TRAF5 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA024153ESR1HU	TRAF5 Antibody	Human	ELISA, IHC
CSB-PA024153ESR2HU	TRAF5 Antibody	Human	ELISA, IHC
CSB-PA024153LA01HU	TRAF5 Antibody	Human	ELISA, IHC
CSB-PA146040	TRAF5 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA069375	TRAF5 Antibody	Human,Mouse	ELISA,IHC

TRAF5 Proteins

TRAF5 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP024153MO CSB-EP024153MO CSB-BP024153MO CSB-MP024153MO CSB-EP024153MO-B	Recombinant Mouse TNF receptor-associated factor 5 (Traf5)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

TRAF5 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP024153HU CSB-BP024153HU CSB-MP024153HU CSB-EP024153HU-B	Recombinant Human TNF receptor-associated factor 5 (TRAF5)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP024153HU	Recombinant Human TNF receptor-associated factor 5 (TRAF5)	E.coli

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TRAF5

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