Recombinant Human TNF receptor-associated factor 5(TRAF5)

Code CSB-EP024153HU
Size US$1726
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP024153HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TRAF5.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP024153HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) TRAF5.
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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names TRAF5
Uniprot No. O00463
Research Area Immunology
Alternative Names MGC:39780 ; RING finger protein 84; RNF 84; RNF84; TNF receptor associated factor 5; TNF receptor-associated factor 5; TRAF 5; Traf5; TRAF5_HUMAN
Species Homo sapiens (Human)
Source E.coli
Expression Region 1-557aa
Target Protein Sequence MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 80.4kDa
Protein Length Full Length
Tag Info N-terminal 6xHis-SUMO-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

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Target Data

Function Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
Gene References into Functions
  1. High TRAF5 expression is associated with colorectal cancer. PMID: 29328486
  2. These findings indicate that miR-26b might influence TRAF5-MAPK signaling pathways to facilitate the malignant progression of melanoma cells. PMID: 26872428
  3. findings reveal a direct link between TRAF5-mediated ubiquitination and RORgammat protein regulation PMID: 26453305
  4. This study provides evidence that TRAF5 and TRAF3IP2 genes are involved in the development of Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) syndrome. PMID: 24416204
  5. Data indicate that TNF receptor-associated factor 5 (TRAF5) gene is involved in the development of acute anterior uveitis (AAU) and pediatric uveitis. PMID: 24020968
  6. TRAF3 and TRAF5 are overexpressed in inflammatory bowel disease PMID: 23329887
  7. Numbl interacted with tumor necrosis factor receptor-associated factor 5, which signals upstream and is required for the activation of NF-kappaB, and committed it to proteasomal degradation by promoting K48-linked polyubiquitination of TRAF5 PMID: 22593207
  8. Resutls indicate that TRAF5 may be a key molecule in the innate response against viral infection. PMID: 20161788
  9. TRAF5 has a role in TNF-alpha induced IKK phosphorylation of NF-kappaB p65 PMID: 12842894
  10. These findings provide evidence for the association of an SNP upstream of a strong candidate RA susceptibility gene, TRAF5. PMID: 17277003

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Subcellular Location Cytoplasm, Cytoplasm, cytosol
Protein Families TNF receptor-associated factor family, A subfamily
Tissue Specificity Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
Database Links

HGNC: 12035

OMIM: 602356

KEGG: hsa:7188

STRING: 9606.ENSP00000261464

UniGene: Hs.523930

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