TRIM59 Antibody

Code CSB-PA108876
Size US$297
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  • Western blot analysis of extracts from NIH-3T3 cells, using TRIM59 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue using TRIM59 antibody.
  • Immunofluorescence analysis of HeLa cells, using TRIM59 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TRIM59 Polyclonal antibody
Uniprot No.
Target Names
TRIM59
Alternative Names
TRIM59; RNF104; TRIM57; TSBF1; Tripartite motif-containing protein 59; RING finger protein 104; Tumor suppressor TSBF-1
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human TRIM59.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:100
IF 1:100-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May serve as a multifunctional regulator for innate immune signaling pathways.
Gene References into Functions
  1. TRIM59 expression is upregulated in hepatocellular carcinoma (HCC) cells; TRIM59 promotes cell proliferation, migration and invasion in HCC cells PMID: 29442042
  2. The level of TRIM59 is correlated with malignant features of colorectal carcinoma (CRC)and may serve as potential therapeutic and preventive strategies for CRC PMID: 28849218
  3. Knockdown of TRIM59 may be a promising strategy concerning the early detection and treatment of Renal cell carcinoma. PMID: 28719348
  4. TRIM59 overexpression is associated with colorectal cancer metastasis. PMID: 28534983
  5. our results suggest that rs1141023 polymorphism contributes to increased predisposition to gastric cancer PMID: 28009992
  6. The expression of TRIM59 was significantly elevated in cervical cancers. PMID: 27662486
  7. These data suggest the oncogenic abilities of TRIM59 in osteosarcoma, which promote osteosarcoma cell proliferation, migration and invasion PMID: 27121462
  8. we knocked down TRIM59 and found that p53 protein expression levels did not upregulate, so we proposed that TRIM59 may promote NSCLC cell growth through other pathways but not the p53 signaling pathway PMID: 26599082
  9. TRIM59 interacts with P53, promoting its ubiquitination and degradation, and TRIM59 might promote gastric carcinogenesis via this mechanism. PMID: 25046164
  10. These findings indicate that TRIM59 may serve as a multifunctional regulator for innate immune signaling pathways. PMID: 22588174
  11. PMID:12095697 pertains to mouse Mrf1 gene which appears to be the homolog of human TSBF1. PMID: 12095697

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Subcellular Location
Endoplasmic reticulum membrane; Single-pass membrane protein.
Protein Families
TRIM/RBCC family
Database Links

HGNC: 30834

OMIM: 616148

KEGG: hsa:286827

STRING: 9606.ENSP00000311219

UniGene: Hs.212957

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