TTR Antibody

Datasheet
Code CSB-PA143118
Size US$299
Uniprot No. P02766
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human stomach cancer tissue using CSB-PA143118(TTR Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA143118(TTR Antibody) at dilution 1/10, on the right is treated with fusion protein. (Original magnification: ×200)
Immunogen Fusion protein of Human TTR
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,IHC;ELISA:1:1000-1:5000,IHC:1:25-1:100
Relevance This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias Transthyretin
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Target Names TTR
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Involvement in disease Amyloidosis, transthyretin-related (AMYL-TTR); Hyperthyroxinemia, dystransthyretinemic (DTTRH); Carpal tunnel syndrome 1 (CTS1)
Subcellular Location Secreted, Cytoplasm
Protein Families Transthyretin family
Tissue Specificity Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Database Links

HGNC: 12405

OMIM: 105210

KEGG: hsa:7276

STRING: 9606.ENSP00000237014

UniGene: Hs.427202

Pathway Th17 cell differentiation
Thyroid hormone synthesis

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