UBA7 Antibody

Datasheet

Code	CSB-PA991105
Size	US$297
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Image	Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using UBE1L antibody. Western blot analysis of extracts from HeLa cells, using UBE1L antibody. Western blot analysis of extracts from JK cells (Lane 2), using UBE1L antiobdy. The lane on the left is treated with synthesized peptide.
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) UBA7 Polyclonal antibody

Uniprot No.

P41226

Target Names

UBA7

Alternative Names

D8 antibody; MGC12713 antibody; UBA1, ubiquitin activating enzyme E1 homolog B antibody; UBA1B antibody; UBA7 antibody; UBA7, ubiquitin activating enzyme E1 antibody; UBA7_HUMAN antibody; Ube 1L antibody; UBE 2 antibody; UBE1L antibody; UBE2 antibody; Ubiquitin activating enzyme 2 antibody; Ubiquitin activating enzyme E1 homolog antibody; Ubiquitin Activating Enzyme E1 Like antibody; Ubiquitin activating enzyme E1 related protein antibody; Ubiquitin-activating enzyme 7 antibody; Ubiquitin-activating enzyme E1 homolog antibody; ubiquitin-activating enzyme-2 antibody; ubiquitin-like modifier activating enzyme 7 antibody; Ubiquitin-like modifier-activating enzyme 7 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthesized peptide derived from C-terminal of Human UBE1L.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene References into Functions

RNF170, an endoplasmic reticulum (ER)-associated ubiquitin E3 ligase, interacted with pUL50 and promoted pUL50-mediated UBE1L degradation via ubiquitination. PMID: 29743376
the cellular effects of progerin expression in Hutchinson-Gilford progeria syndrome are transduced, at least in part, through reduced function of the Ran GTPase and E2 SUMOylation pathways. PMID: 21670151
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) PMID: 20601676
UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia PMID: 11891284
RA treatment of APL and other RA-responsive leukemic cells induced expression of UBE1L and ISG15 as well as intracellular ISG15 conjugates. A physical association was found between UBE1L and ISG15 in vivo. PMID: 14976209
Ube1L was required for transfer of ISG15 to UbcH8 and for binding of Ube1L to UbcH8 PMID: 18583345
UBE1L-ISG15 preferentially inhibits cyclin D1 in lung cancer PMID: 19074853

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Protein Families

Ubiquitin-activating E1 family

Tissue Specificity

Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines.

Database Links

HGNC: 12471

OMIM: 191325

KEGG: hsa:7318

STRING: 9606.ENSP00000333266

UniGene: Hs.16695

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Service

Phage Display Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Ubiquitin mediated proteolysis

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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