UBE2V2 Antibody

Datasheet

Code	CSB-PA025484DA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HL60 whole cell lysate, K562 whole cell lyaste, Mouse brain tissue, Rat brain tissue All lanes: UBE2V2 antibody at 1.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 17 kDa Observed band size: 17 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA025484DA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA025484DA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) UBE2V2 Polyclonal antibody

Uniprot No.

Q15819

Target Names

UBE2V2

Alternative Names

1 alpha 25 dihydroxyvitamin D3 inducible antibody; DDVit 1 antibody; DDVIT1 antibody; EDAF-1 antibody; EDAF1 antibody; EDPF-1 antibody; EDPF1 antibody; Enterocyte differentiation associated factor EDAF 1 antibody; Enterocyte differentiation promoting factor antibody; Enterocyte differentiation-associated factor 1 antibody; Enterocyte differentiation-promoting factor 1 antibody; Methyl methanesulfonate sensitive 2 antibody; MMS 2 antibody; MMS2 antibody; MMS2 homolog antibody; UB2V2_HUMAN antibody; UBE2V 2 antibody; UBE2V2 antibody; Ubiquitin conjugating enzyme E2 variant 2 antibody; Ubiquitin conjugating enzyme E2v2 antibody; Ubiquitin-conjugating enzyme E2 variant 2 antibody; UEV 2 antibody; UEV2 antibody; Vitamin D3 inducible protein antibody; Vitamin D3-inducible protein antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Ubiquitin-conjugating enzyme E2 variant 2 protein (2-145AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The UBE2V2 Antibody (Product code: CSB-PA025484DA01HU) is Non-conjugated. For UBE2V2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA025484DB01HU	UBE2V2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025484DC01HU	UBE2V2 Antibody, FITC conjugated
Biotin	CSB-PA025484DD01HU	UBE2V2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Gene References into Functions

Functional analysis of selected regulated proteins revealed that knockdown of HNRPD, PHB2 and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP resulted in decreased HCMV replication. PMID: 25910425
suppression of hMMS2 reverses L-OHP tolerance in differentiated human colorectal carcinoma cells by promoting apoptosis PMID: 24846979
UBE2v2 signalling through PCNA ubiquitination is not required for immunoglobulin diversification in DT40 cells. PMID: 15725630
Insight into the influence of protein dynamics on the affinity of ubiquitin for Mms2. PMID: 15952783
Mms2 physical association with ubiquitin is correlated with its ability to promote Lys63-linked ubiquitin chain assembly PMID: 17964296
These results point to a high level of redundancy in the DNA damage tolerance pathway and suggest the existence of another hMMS2 variant (hMMSv) or complex that can compensate for its loss. PMID: 18284681

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Protein Families

Ubiquitin-conjugating enzyme family

Tissue Specificity

Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.

Database Links

HGNC: 12495

OMIM: 603001

KEGG: hsa:7336

STRING: 9606.ENSP00000428209

UniGene: Hs.491695

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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