Vegfc Antibody

1. As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiogenesis through regulation of, and direct interaction with, VEGF-C. PMID: 28545716
2. Fluid shear stress regulates vascular remodeling via VEGFR-3 activation, independently of its ligand, VEGF-C, in the uterus during pregnancy. PMID: 28849193
3. A novel heparin conjugate (LHbisD4) is shown to prevent lymphangiogenesis by blocking the vascular endothelial growth factor C (VEGF-C) induced signaling pathway. PMID: 28586719
4. lymphangiogenesis is regulated by two distinct proteolytic mechanisms of ligand activation: one in which VEGFC activation by ADAMTS3 and CCBE1 spatially and temporally patterns developing lymphatics, and one in which VEGFD activation by a distinct proteolytic mechanism may be stimulated during inflammatory lymphatic growth PMID: 27159393
5. These results reveal an unexpected role for VEGF-C, a major lymphangiogenic growth factor, in the transition to fetal liver erythropoiesis. PMID: 27343251
6. Data show that in the MCF-7 breast cancer cell line, only MT1X metallothioneins (MTs) positively correlated with vascular endothelial growth factor C (VEGFC). PMID: 27107086
7. The authors show that VEGF-C is necessary for perinatal lymphangiogenesis, but required for adult lymphatic vessel maintenance only in the intestine. PMID: 26459520
8. MT1-MMP directly cleaves LYVE-1 on lymphatic endothelial cells to inhibit LYVE-1-mediated lymphangiogenic responses and restrains the production of VEGF-C. PMID: 26926389
9. Results showed that the VEGF-C/VEGFR-3 system underlies the protective effect of ischemic preconditioning against forebrain ischemia in the mouse hippocampus PMID: 25637798
10. Vascular endothelial growth factor C/VEGFR-3 signaling modifies HS and CCL21 gradients around lymphatics, regulating lymphocyte migration. PMID: 25606800
11. Coronary artery stem development first requires VEGF-C to stimulate vessel growth around the outflow tract. PMID: 25271623
12. Data show that the expression of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE 1) was similar with vascular endothelial growth factor C (VEGF-C), but its peak appeared 1-2 d later than that of VEGF-C. PMID: 25270205
13. reveal the evolutionary conservation of the lymphatic-like phenotype of the Schlemm's canal (SC), implicate VEGF-C and VEGFR-3 as critical regulators of SC lymphangiogenesis PMID: 25061878
14. Sinus venosus-derived and endocardial-derived migratory routes unite to form the coronary vasculature, with the former requiring VEGFC - a tissue-specific mediator of blood endothelial development. PMID: 25377552
15. suggest that correction of defective lymphatic function with VEGF-C has potential as a therapeutic strategy for inflammatory bowel disease. PMID: 25105363
16. VEGF-C/VEGFR3 signaling plays an important role in the resolution of skin inflammation PMID: 24252749
17. The findings indicate that VEGF-C overexpression can induce pulmonary lymphangiectasia during a critical period in perinatal development. PMID: 24429550
18. Our findings indicate that tumors may develop resistance to anti-VEGF therapy by activating the VEGF-C pathway PMID: 24333721
19. Epidermal keratinocyte proliferation in vitro was not affected by VEGF-C or VEGF-D. PMID: 23695550
20. VEGFC genetically interacts with Sox17 to regulate lymphangiogenesis in zebrafish. PMID: 23520166
21. High vascular endothelial growth factor-C leads to tumor lymphangiogenesis and growth of gastric cancer. PMID: 23475632
22. Vascular endothelial growth factor-C and -D are involved in lymphangiogenesis in mouse unilateral ureteral obstruction. PMID: 22932121
23. VEGF-C promotes immune tolerance in murine melanoma. PMID: 22832193
24. VEGF-C derived from CD11b(+) cells play a critical role in angiogenesis and lymphangiogenesis in a murine model of hind limb ischemia. PMID: 23219511
25. Vegfc acts in two distinct modes during development: as a paracrine factor secreted from arteries to guide closely associated lymphatic vasculature and as an autocrine factor to drive migratory persistence during angiogenesis. PMID: 23462469
26. primary tumors -via secretion of VEGF-C- can induce hyperplasia of the sentinel lymph node lymphatic vessel network and thereby promote their further spread. PMID: 23076721
27. The extent of both lymphatic proliferation and drainage parallels the progression of lesion severity, as does the up-regulation of pro-lymphangiogenic factors VEGF-C, VEGFR-3, ANG-1, and ANG-2. IL-4-stimulated cells PMID: 22574929
28. new function of CEBP-delta in lymphangiogenesis through regulation of VEGFR3 signaling in lymphatic endothelial cells PMID: 21666710
29. Data show that that OUBC induces profound lymphangiogenesis in the tumor and SLN and substantial lymphatic metastasis to SLN through VEGF-C/D-VEGFR-3 signaling pathway. PMID: 21481239
30. VEGF-C binds to heparan sulfate purified from primary lymphatic endothelia PMID: 21343305
31. AFP mRNA and VEGF-C mRNA in peripheral blood were significantly correlated with recurrence and metastasis of hepatocellular carcinoma. PMID: 20506647
32. In conclusion, these newly identified VEGF-C isoforms represent a new class of proteins, which are potentially involved in epithelial cell adhesion and proliferation through novel receptor pathways. PMID: 20415667
33. interaction between neuropilin-2 and VEGFR3 mediates proper lymphatic vessel sprouting in response to VEGF-C. PMID: 20065093
34. Increased level of VEGF-C stimulates cell growth and alters the metastatic pattern of orthotopic prostate tumors. PMID: 19821979
35. Results identify the IGF-IR as a positive regulator of VEGF-C expression and implicate it in the control of lymphatic metastasis. PMID: 12649170
36. Data demonstrate the expression of vascular endothelial growth factor receptor-3 and vascular endothelial growth factor-C on corneal dendritic cells, which implicate a potential relationship between lymphangiogenesis and leukocyte trafficking in the eye. PMID: 12819011
37. VEGF-C is required for sprouting of the first lymphatic vessels from embyronic veins. PMID: 14634646
38. Forty percent of functional lymphatics with VEGF-C-overexpressing tumors contained proliferating lymphatic endothelial cells. These lymphatic vessels displayed a retrograde draining pattern, indicating possible dysfunction of the intraluminal valves. PMID: 15231646
39. VEGF-C and VEGF-D are ligands for the integrin alpha9beta1 PMID: 15590642
40. Overexpression of VEGF-C causes transient lymphatic hyperplasia but not increased lymphangiogenesis in regenerating skin. PMID: 15890974
41. VEGF-C expression peaked at the initiation of lymphangiogenesis but was reduced to lower levels throughout organization and maturation. PMID: 16648194
42. VEGF-C facilitates lymphatic metastasis by increasing the delivery of cancer cells to lymph nodes. PMID: 16912183
43. results suggest the presence of lymphatic capillaries throughout the skeletal muscle, and present the localisation of VEGF-C and -D in the muscles PMID: 16924525
44. important role of VEGF-C-induced lymph node lymphangiogenesis in the promotion of cancer metastasis beyond the sentinel lymph nodes. PMID: 17032920
45. Chy-3 mice carry a large chromosomal deletion that includes Vegfc; phenotype includes a hypoplastic dermal lymphatic network, a lateral lymphatic pathway directly connecting the inguinal to the axillary lymph node, lower limb lymphatic abnormalities . PMID: 17584866
46. VEGF-C levels were not changed either in healthy or in diabetic muscle after the exercise training. PMID: 17766486
47. VEGF-C is a new RANKL target gene in osteoclasts and functions as an autocrine factor regulating osteoclast activity PMID: 18359770
48. These results suggest VEGF-C- and VEGF-D-independent functions for VEGFR-3 in the early embryo. PMID: 18519586
49. activation of VEGF-C-VEGF receptor 3 has critical roles in reconnection of the collecting lymph vessels in adult mice. PMID: 18951277
50. Data show that blood vessels can undergo VEGF-C-induced angiogenesis even after down-regulation of VEGFR-3 in embryos; but transient VEGF-C expression in adults can induce long-lasting lymphatic hyperplasia with no side effects on blood vasculature. PMID: 18988807

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KEGG: mmu:22341

STRING: 10090.ENSMUSP00000033919

UniGene: Mm.1402