VEGFC, also known as Vascular Endothelial Growth Factor C, is a crucial protein involved in the regulation of lymphangiogenesis and angiogenesis. It has several common aliases, including VEGF-3 and VPF-C. VEGFC acts by binding to its receptors VEGFR-2 and VEGFR-3, initiating a signaling cascade that promotes cell survival, proliferation, and migration of endothelial cells.
This protein is associated with various diseases such as lymphedema and certain types of cancer, where its overexpression can lead to abnormal lymphatic vessel formation and tumor growth. In drug development, agents targeting the VEGFC/VEGFR pathway are being actively investigated, with some showing promise in preclinical and early - stage clinical trials to inhibit tumor angiogenesis and lymphangiogenesis.
Recombinant Human Vascular endothelial growth factor C (VEGFC) (CSB-EP025835HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
VEGFC Antibody (CSB-PA07545A0Rb)
Validated Data
Western Blot
Positive WB detected in: 293T whole cell lysate
All lanes: VEGFC antibody at 2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 47 kDa
Observed band size: 47 kDa
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA07545A0Rb at dilution of 1:100
Human Vascular Endothelial cell Growth Factor C,VEGF-C ELISA KIT (CSB-E04759h)
Validated Data
Code: CSB-E04759h
Size: 96T,5×96T,10×96T
Sensitivity: 3.9 pg/mL
Detection Range: 15.6 pg/mL-1000 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following VEGFC reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
VEGFC Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA07545A0Rb | VEGFC Antibody | Human | ELISA, WB, IHC |
CSB-PA07545B0Rb | VEGFC Antibody, HRP conjugated | Human | ELISA |
CSB-PA07545C0Rb | VEGFC Antibody, FITC conjugated | Human | |
CSB-PA07545D0Rb | VEGFC Antibody, Biotin conjugated | Human | ELISA |
CSB-PA005364 | VEGFC Antibody | Human,Mouse,Rat | WB, ELISA |
VEGFC Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA07725A0Rb | Vegfc Antibody | Mouse | ELISA |
CSB-PA07725B0Rb | Vegfc Antibody, HRP conjugated | Mouse | ELISA |
CSB-PA07725C0Rb | Vegfc Antibody, FITC conjugated | Mouse | |
CSB-PA07725D0Rb | Vegfc Antibody, Biotin conjugated | Mouse | ELISA |
CSB-PA025835LA01MO | Vegfc Antibody | Mouse | ELISA |
CSB-PA025835LC01MO | Vegfc Antibody, FITC conjugated | Mouse | |
CSB-PA025835LD01MO | Vegfc Antibody, Biotin conjugated | Mouse | ELISA |
VEGFC Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-EP025835MO | Recombinant Mouse Vascular endothelial growth factor C (Vegfc) | E.coli |
CSB-YP025835MO | Recombinant Mouse Vascular endothelial growth factor C (Vegfc) | Yeast |
CSB-BP025835MO CSB-MP025835MO CSB-EP025835MO-B |
Recombinant Mouse Vascular endothelial growth factor C (Vegfc) | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFC Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP025835HU CSB-EP025835HU CSB-BP025835HU CSB-MP025835HU CSB-EP025835HU-B |
Recombinant Human Vascular endothelial growth factor C (VEGFC) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP025835HU | Recombinant Human Vascular endothelial growth factor C (VEGFC) | E.coli |
CSB-BP025835HU(A4) | Recombinant Human Vascular endothelial growth factor C (VEGFC) | Baculovirus |
CSB-BP025835HU(A4)c7 | Recombinant Human Vascular endothelial growth factor C (VEGFC) | Baculovirus |
VEGFC Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP025835RA CSB-EP025835RA CSB-BP025835RA CSB-MP025835RA CSB-EP025835RA-B |
Recombinant Rat Vascular endothelial growth factor C (Vegfc) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
VEGFC ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04759h | Human Vascular Endothelial cell Growth Factor C,VEGF-C ELISA KIT | serum, plasma, tissue homogenates | 3.9 pg/mL |
VEGFC ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E07361m | Mouse Vascular Endothelial cell Growth Factor C,VEGF-C ELISA kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 0.39 pg/mL |