XIAP Antibody

Datasheet
Code CSB-PA968176
Size US$299
Uniprot No. P98170
Image
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human normal kidney tissue, Primary antibody: CSB-PA968176(XIAP Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
Immunogen Synthetic peptide of Human XIAP
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications ELISA,WB;ELISA:1:1000-1:2000,WB:1:200-1:1000
Relevance This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme.
Form Liquid
Conjugate Non-conjugated
Storage Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method Antigen affinity purification
Isotype IgG
Alias X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Target Names XIAP
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include
Involvement in disease Lymphoproliferative syndrome, X-linked, 2 (XLP2)
Subcellular Location Cytoplasm, Nucleus
Protein Families IAP family
Tissue Specificity Ubiquitous, except peripheral blood leukocytes.
Database Links

HGNC: 592

OMIM: 300079

KEGG: hsa:331

STRING: 9606.ENSP00000347858

UniGene: Hs.356076

Pathway Focal adhesion
NF-kappa B signaling pathway
Apoptosis
Necroptosis
Ubiquitin mediated proteolysis
NOD-like receptor signaling pathway

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