Recombinant Arabidopsis thaliana Protein DAMAGED DNA-BINDING 2 (DDB2), partial

Code CSB-YP740641DOA
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Source Yeast
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Code CSB-EP740641DOA
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Source E.coli
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Code CSB-EP740641DOA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP740641DOA
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Source Baculovirus
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Code CSB-MP740641DOA
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
DDB2
Uniprot No.
Alternative Names
DDB2; At5g58760; MZN1.20Protein DAMAGED DNA-BINDING 2; UV-damaged DNA-binding protein 2
Species
Arabidopsis thaliana (Mouse-ear cress)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex including DDB1A and CUL4. Required for DNA repair. Binds to DDB1A to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Involved in UV-B tolerance and genome integrity. In association with ATCSA-1, is necessary for repair of UV-B-induced DNA lesions.
Gene References into Functions
  1. DDB2 role in the repair of UV-induced DNA lesions PMID: 28325872
  2. DDB2 but not ATCSA-1 expression is upregulated upon UV treatment. PMID: 20128879
  3. AtUV-DDB2 functions in DNA repair and has a direct or indirect influence on cell proliferation in the plant meristem. [UV-DDB2] PMID: 16786303
Subcellular Location
Nucleus. Note=Broadly distributed over chromatin.
Protein Families
WD repeat DDB2/WDR76 family
Tissue Specificity
Expressed in roots and flowers. Expressed at low levels in stems.
Database Links

KEGG: ath:AT5G58760

STRING: 3702.AT5G58760.1

UniGene: At.29266

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