DDB2

DNA damage-binding protein 2 is a protein in humans that is encoded by DDB2 gene. Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

DDB2 Antibodies

DDB2 Antibodies for Homo sapiens (Human)

DDB2 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

DDB2 Antibodies for Oryza sativa subsp. japonica (Rice)

DDB2 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

DDB2 Proteins

DDB2 Proteins for Bos taurus (Bovine)

DDB2 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

DDB2 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

DDB2 Proteins for Gallus gallus (Chicken)

DDB2 Proteins for Arabidopsis thaliana (Mouse-ear cress)

DDB2 Proteins for Homo sapiens (Human)

DDB2 Proteins for Mus musculus (Mouse)

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