Recombinant Bovine Cellular tumor antigen p53(TP53)

Code CSB-YP024077BO
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Source Yeast
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Code CSB-EP024077BO
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Source E.coli
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Code CSB-EP024077BO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP024077BO
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Source Baculovirus
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Code CSB-MP024077BO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names TP53
Uniprot No. P67939
Alternative Names TP53; Cellular tumor antigen p53; Tumor suppressor p53
Species Bos taurus (Bovine)
Expression Region 1-386
Target Protein Sequence MEESQAELNV EPPLSQETFS DLWNLLPENN LLSSELSAPV DDLLPYTDVA TWLDECPNEA PQMPEPSAPA APPPATPAPA TSWPLSSFVP SQKTYPGNYG FRLGFLQSGT AKSVTCTYSP SLNKLFCQLA KTCPVQLWVD SPPPPGTRVR AMAIYKKLEH MTEVVRRCPH HERSSDYSDG LAPPQHLIRV EGNLRAEYLD DRNTFRHSVV VPYESPEIDS ECTTIHYNFM CNSSCMGGMN RRPILTIITL EDSCGNLLGR NSFEVRVCAC PGRDRRTEEE NLRKKGQSCP EPPPRSTKRA LPTNTSSSPQ PKKKPLDGEY FTLQIRGFKR YEMFRELNDA LELKDALDGR EPGESRAHSS HLKSKKRPSP SCHKKPMLKR EGPDSD
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
Gene References into Functions
  1. The effect of p53 expression on the development of cloned embryos, and its interaction with HDAC1 and DNMT3A are reported. PMID: 25753134
  2. Bov-A2 insertion into the TP53 promoter in Antilopinae and Tragelaphini may not only provide a genetic network that regulates mammary involution, but can also answer the need for rapid mammary involution in Savanna antelopes PMID: 25653076
  3. PI3K/Akt and p53 are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide PMID: 14588144
  4. Results demonstrate that embryonic developmental potential is related to the time of first cleavage and that p66(shc), but not p53, is up-regulated in early arrested in vitro-produced bovine embryos. PMID: 15064348
Involvement in disease p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.
Subcellular Location Cytoplasm, Nucleus, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix
Protein Families P53 family
Database Links

KEGG: bta:281542

STRING: 9913.ENSBTAP00000001420

UniGene: Bt.49712

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  Email: [email protected]
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