Recombinant Bovine Peroxisome proliferator-activated receptor gamma(PPARG) ,partial

Code CSB-YP018424BO
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Source Yeast
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Code CSB-EP018424BO
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Source E.coli
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Code CSB-EP018424BO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP018424BO
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Source Baculovirus
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Code CSB-MP018424BO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names PPARG
Uniprot No. O18971
Alternative Names PPARG; NR1C3; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3
Species Bos taurus (Bovine)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

(From Uniprot)
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels.
Gene References into Functions
  1. Three novel SNPs of the bovine PPARgamma gene were identified in 514 individuals from six Chinese cattle breeds: SNP1 (AC_000179.1 g.57386668 C > G) in intron 2 and SNP2 (AC_000179.1 g.57431964 C > T) and SNP3 (AC_000179.1 g.57431994 T > C) in exon 7. PMID: 28481711
  2. These results indicated that docosahexaenoic acid may attenuate lipopolysaccharide-stimulated inflammatory response in bovine mammary epithelial cells by suppressing NF-kappaB activation through a mechanism partly dependent on PPARgamma activation. PMID: 28095338
  3. PPARgamma is a positive regulator of milk fat synthesis in dairy cow mammary epithelial cells. PMID: 27287918
  4. An Asp7Gly substitution in PPARG is associated with adiposity. PMID: 24466299
  5. upregulation of PPARgamma was observed in the backfat tissue of Lilu cattle with increasing age PMID: 24200561
  6. Co-culture of adipocytes and myoblasts elicited an increase in C/EBPbeta and PPAR-gamma gene expression in differentiated myoblasts and an increase in GPR43 gene expression in adipocytes. PMID: 22748806
  7. A potential association of an single nucleotide polymorphism (72472 GT in exon7) of the bovine PPAR-gamma gene with carcass and meat quality traits, was evaluated. PMID: 22930427
  8. study demonstrates the co-expression of DLX3, PPARG and SP1 in trophoblast binucleated cell(BNC)nuclei; this suggests a possible role of these transcription factors through BNC specific genes at the time of pre-placental differentiation PMID: 21937107
  9. Single nucleotide polymorphisms in coding region of the PPARgamma gene, were examined. PMID: 20306301
  10. oxidative stress attenuates PPAR gamma expression and activity in vascular endothelial cells PMID: 20302927
  11. The effects of dietary fat components on the expression of PPAR-gamma AND PPAR-gamma coactivator 1 in cultured bovine preadipocytes are reported. PMID: 20154154
  12. Intramammary infection elicited a strong transcriptomic response, leading to potent activation of pro-inflammatory pathways that were associated with a marked inhibition of lipid synthesis, stress-activated kinase signaling cascades, and PPAR signaling. PMID: 19925655
  13. PPARgamma1 has bifunctional properties in the regulation of KDR gene expression mediated via interaction with both Sp1 and Sp3 PMID: 15111490
  14. There is evidence of cotranscription and intergenic splicing events between the PPARG gene and the neighboring gene TSEN2 in cattle. Two types of chimeric transcripts are observed. PMID: 16595010

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Subcellular Location Nucleus, Cytoplasm
Protein Families Nuclear hormone receptor family, NR1 subfamily
Tissue Specificity Highest expression in adipose tissue. Lower in spleen and lung. Also detected in ovary, mammary gland and small intestine.
Database Links

KEGG: bta:281993

STRING: 9913.ENSBTAP00000041555

UniGene: Bt.3862


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