Recombinant Chicken Cellular tumor antigen p53(TP53)

Code CSB-YP024077CH
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Source Yeast
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Code CSB-EP024077CH
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Source E.coli
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Code CSB-EP024077CH-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP024077CH
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Source Baculovirus
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Code CSB-MP024077CH
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names TP53
Uniprot No. P10360
Alternative Names TP53; Cellular tumor antigen p53; Tumor suppressor p53
Species Gallus gallus (Chicken)
Expression Region 1-367
Target Protein Sequence MAEEMEPLLE PTEVFMDLWS MLPYSMQQLP LPEDHSNWQE LSPLEPSDPP PPPPPPPLPL AAAAPPPLNP PTPPRAAPSP VVPSTEDYGG DFDFRVGFVE AGTAKSVTCT YSPVLNKVYC RLAKPCPVQV RVGVAPPPGS SLRAVAVYKK SEHVAEVVRR CPHHERCGGG TDGLAPAQHL IRVEGNPQAR YHDDETTKRH SVVVPYEPPE VGSDCTTVLY NFMCNSSCMG GMNRRPILTI LTLEGPGGQL LGRRCFEVRV CACPGRDRKI EEENFRKRGG AGGVAKRAMS PPTEAPEPPK KRVLNPDNEI FYLQVRGRRR YEMLKEINEA LQLAEGGSAP RPSKGRRVKV EGPQPSCGKK LLQKGSD
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).
Gene References into Functions
  1. Protein p53 occurs at key stages of development: in the esophagus during the remodeling of esophageal glands, in the proventriculus during the differentiation of the epithelium of the mucosa and in the gizzard during the formation of tubular glands. PMID: 24068480
  2. p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes. PMID: 21447558
  3. Results suggest that extensive deletions are efficient mechanisms of TP53 inactivation, occurring as early events during the immortalization of v-src-transformed chicken cells. PMID: 15723564
  4. An initial down-regulation of p53 allowed the SC-2 cells to bypass senescence. The inactivation of p53, and consequently p21WAF1, likely contributed to the SC-2 cells becoming a fully immortal cell line. PMID: 16813656
  5. results suggest that the short form of p53 could play a role in the initiation of apoptosis induced by the chemotherapeutic compound, and that the regulation of its expression may be important for the maintenance of transformation status. PMID: 16820712
  6. Nitric oxide-induced cell death operates through p53-independent pathways, including a mitochondrial apoptotic pathway in chick embryo cardiomyocytes. PMID: 17630850

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Subcellular Location Cytoplasm, Nucleus
Protein Families P53 family
Database Links

KEGG: gga:396200

UniGene: Gga.706

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  Email: [email protected]
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