Recombinant Chicken Interferon regulatory factor 3(IRF3)

Code CSB-YP011818CH
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Source Yeast
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Code CSB-EP011818CH
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Source E.coli
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Code CSB-EP011818CH-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011818CH
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Source Baculovirus
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Code CSB-MP011818CH
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names IRF3
Uniprot No. Q90643
Alternative Names IRF3Interferon regulatory factor 3; IRF-3
Species Gallus gallus (Chicken)
Expression Region 1-491
Target Protein Sequence MAALDSEGDA QKLRFGPWLL NAVSSGLYRG LCWIDPDRRI FRIPWKHNAR KDVTSSDVEI FKAWAKASGR YEGNAEDPAK WKTNFRCALR STHMFMLLED RSKCNDDPHK VYAVASGVPN DRGSGGPVAG ALQQQPQLLL NHHDLALENT PTDSTEGVAA AALTQVDLDL LQSVLQHCNI SALGSQPTLW AHTGDALPED ALLLPGQDGC LPGPQFQDWR QLEEPLLLGN QPLTGGGCGQ DGAGALPVSE ECAIPAPSPA EELLFQSANP APPPPAGDIG GLPPLLDITI YYRGKMVYQE QVDDSRCVLA YQPLDPAVAE QRLVLFPSPA SLPDPRQRRY TEDLLEVAGL RLEQRAGQLL ATRLKKCKVF WALSQQLEGG EPPLNLLHRD QETTIFDFRV FCTELRDFRD SRRERSPDFT IFLCFGQCFS STKPKESKLI LVKLVPQFCE YWYEQVQRGG ASSLNSGNVS LQLSDSFNLF ELIEQYHMQT D
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the IRF-1 binding site PRD-I.
Gene References into Functions
  1. chTBK1 may be an important immunoregulator for IRF3 and IFNbeta induction in response to viral stimulation in chicken. PMID: 28493975
  2. IRF7 may have conserved functional activity in the avian antiviral response, and plays a crucial role in type I IFN regulation. PMID: 26186542
Subcellular Location Cytoplasm. Nucleus.
Protein Families IRF family
Tissue Specificity Widely expressed with higher expression in lung, spleen and intestine.
Database Links

KEGG: gga:396330

STRING: 9031.ENSGALP00000023072

UniGene: Gga.1087

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Address
7505 Fannin St. Ste 610-312, Houston, TX 77054, USA
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