IRF3

IRF3, or interferon regulatory factor 3, is a transcription factor critical for innate immune responses. Upon activation by pathogen-associated molecular patterns, it undergoes phosphorylation, dimerization, and nuclear translocation to induce type I interferons and proinflammatory cytokines.
IRF3 mediates signaling through TLR3/4, RIG-I, and cGAS-STING pathways. Dysregulation contributes to autoimmune diseases like lupus, viral infections, and cancer. Small-molecule modulators targeting IRF3 phosphorylation or nuclear import are under preclinical evaluation for antiviral and inflammatory disorder therapies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

IRF3 Antibody (CSB-PA952191)

Validated Data

Western blot analysis of hela Cell Lysate, antibody was diluted at 1:1000. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-tonsils, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200

The following IRF3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IRF3 Antibodies

IRF3 Proteins

IRF3 Antibodies

IRF3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA011818GA01HU	IRF3 Antibody	Human	ELISA,WB,IHC,IF
CSB-PA029024	Phospho-IRF3 (Ser386) Antibody	Human	ELISA,WB
CSB-PA003063	IRF3 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA011238	Phospho-IRF3 (S396) Antibody	Human,Mouse,Rat	WB, ELISA
CSB-PA011239	Phospho-IRF3 (S386) Antibody	Human	WB, ELISA
CSB-PA011240	Phospho-IRF3 (S385) Antibody	Human	WB, IHC, IF, ELISA
CSB-PA011241	IRF3 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA011242	IRF3 Antibody	Human	WB, IHC, ELISA
CSB-PA572418	IRF3 Antibody	Human	ELISA,IHC
CSB-PA283183	IRF3 Antibody	Human	ELISA,WB,IHC
CSB-PA011818LA01HU	IRF3 Antibody	Human	ELISA, WB, IHC, IF
CSB-PA011818LB01HU	IRF3 Antibody, HRP conjugated	Human	ELISA
CSB-PA011818LC01HU	IRF3 Antibody, FITC conjugated	Human
CSB-PA011818LD01HU	IRF3 Antibody, Biotin conjugated	Human	ELISA
CSB-PA510322	IRF3 Antibody	Human	IHC,ELISA
CSB-PA952191	IRF3 Antibody	Human	IHC,ELISA
CSB-RA011818A386phHU	Phospho-IRF3 (S386) Recombinant Monoclonal Antibody	Human	ELISA, WB

IRF3 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA011818YA01MO	Irf3 Antibody	Mouse	ELISA
CSB-PA011818YB01MO	Irf3 Antibody, HRP conjugated	Mouse	ELISA
CSB-PA011818YD01MO	Irf3 Antibody, Biotin conjugated	Mouse	ELISA

IRF3 Proteins

IRF3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP011818MO	Recombinant Mouse Interferon regulatory factor 3 (Irf3)	Yeast
CSB-EP011818MO	Recombinant Mouse Interferon regulatory factor 3 (Irf3)	E.coli
CSB-BP011818MO CSB-MP011818MO CSB-EP011818MO-B	Recombinant Mouse Interferon regulatory factor 3 (Irf3)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRF3 Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP011818PI CSB-EP011818PI CSB-BP011818PI CSB-MP011818PI CSB-EP011818PI-B	Recombinant Pig Interferon regulatory factor 3 (IRF3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRF3 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP011818CH CSB-EP011818CH CSB-BP011818CH CSB-MP011818CH CSB-EP011818CH-B	Recombinant Chicken Interferon regulatory factor 3 (IRF3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

IRF3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP011818HU CSB-BP011818HU CSB-MP011818HU CSB-EP011818HU-B	Recombinant Human Interferon regulatory factor 3 (IRF3)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP011818HU	Recombinant Human Interferon regulatory factor 3 (IRF3)	E.coli

IRF3 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP011818BO CSB-EP011818BO CSB-BP011818BO CSB-MP011818BO CSB-EP011818BO-B	Recombinant Bovine Interferon regulatory factor 3 (IRF3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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IRF3

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