Interferon regulatory factor 3 is a protein in humans that is encoded by IRF3 gene. Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases.

IRF3 Antibodies

IRF3 Antibodies for Homo sapiens (Human)

IRF3 Antibodies for Human

IRF3 Antibodies for Mouse

IRF3 Proteins

IRF3 Proteins for Mus musculus (Mouse)

IRF3 Proteins for Sus scrofa (Pig)

IRF3 Proteins for Gallus gallus (Chicken)

IRF3 Proteins for Homo sapiens (Human)

IRF3 Proteins for Bos taurus (Bovine)


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