Recombinant Delphinapterus leucas Cellular tumor antigen p53(TP53)

Product Type Recombinant Protein
Uniprot No. Q8SPZ3
Abbreviation TP53
Species Delphinapterus leucas (Beluga whale)
Gene Names TP53
Protein Names Recommended name: Cellular tumor antigen p53 Alternative name(s): Tumor suppressor p53
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
Involvement in disease p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.
Subcellular Location Cytoplasm, Nucleus, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix
Protein Families P53 family
Pathway MAPK signaling pathway
p53 signaling pathway
PI3K-Akt signaling pathway
Wnt signaling pathway
Apoptosis
Cell cycle
Mitophagy
Cellular senescence
Cell ageing and metabolism
Sphingolipid signaling pathway
Neurotrophin signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Delphinapterus leucas Cellular tumor antigen p53(TP53),Yeast
Code CSB-YP840473DJB
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MEESQAELGV EPPLSQETFS DLWKLLPENN LLSSELSPAV DDLLLSPEDV ANWLDERPDE APQMPEPPAP AAPTPAAPAP ATSWPLSSFV PSQKTYPGSY GFHLGFLHSG TAKSVTCTYS PALNKLFCQL AKTCPVQLWV SSPPPPGTRV RAMAIYKKSE YMTEVVRRCP HHERCSDYSD GLAPPQHLIR VEGNLRAEYL DDRNTFRHSV VVPYEPPEVG SDCTTIHYNF MCNSSCMGGM NRRPILTIIT LEDSNGNLLG RNSFEVRVCA CPGRDRRTEE ENFHKKGQSC PELPTGSAKR ALPTGTSSSP PQKKKPLDGE YFTLQIRGRE RFEMFRELNE ALELKDAQAG KEPGESRAHS SHLKSKKGQS PSRHKKLMFK REGPDSD
Expression Region 1-387
Protein Description full length protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Delphinapterus leucas Cellular tumor antigen p53(TP53),E.coli
Code CSB-EP840473DJB
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MEESQAELGV EPPLSQETFS DLWKLLPENN LLSSELSPAV DDLLLSPEDV ANWLDERPDE APQMPEPPAP AAPTPAAPAP ATSWPLSSFV PSQKTYPGSY GFHLGFLHSG TAKSVTCTYS PALNKLFCQL AKTCPVQLWV SSPPPPGTRV RAMAIYKKSE YMTEVVRRCP HHERCSDYSD GLAPPQHLIR VEGNLRAEYL DDRNTFRHSV VVPYEPPEVG SDCTTIHYNF MCNSSCMGGM NRRPILTIIT LEDSNGNLLG RNSFEVRVCA CPGRDRRTEE ENFHKKGQSC PELPTGSAKR ALPTGTSSSP PQKKKPLDGE YFTLQIRGRE RFEMFRELNE ALELKDAQAG KEPGESRAHS SHLKSKKGQS PSRHKKLMFK REGPDSD
Expression Region 1-387
Protein Description full length protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Delphinapterus leucas Cellular tumor antigen p53(TP53),Baculovirus
Code CSB-BP840473DJB
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MEESQAELGV EPPLSQETFS DLWKLLPENN LLSSELSPAV DDLLLSPEDV ANWLDERPDE APQMPEPPAP AAPTPAAPAP ATSWPLSSFV PSQKTYPGSY GFHLGFLHSG TAKSVTCTYS PALNKLFCQL AKTCPVQLWV SSPPPPGTRV RAMAIYKKSE YMTEVVRRCP HHERCSDYSD GLAPPQHLIR VEGNLRAEYL DDRNTFRHSV VVPYEPPEVG SDCTTIHYNF MCNSSCMGGM NRRPILTIIT LEDSNGNLLG RNSFEVRVCA CPGRDRRTEE ENFHKKGQSC PELPTGSAKR ALPTGTSSSP PQKKKPLDGE YFTLQIRGRE RFEMFRELNE ALELKDAQAG KEPGESRAHS SHLKSKKGQS PSRHKKLMFK REGPDSD
Expression Region 1-387
Protein Description full length protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Delphinapterus leucas Cellular tumor antigen p53(TP53),Mammalian cell
Code CSB-MP840473DJB
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MEESQAELGV EPPLSQETFS DLWKLLPENN LLSSELSPAV DDLLLSPEDV ANWLDERPDE APQMPEPPAP AAPTPAAPAP ATSWPLSSFV PSQKTYPGSY GFHLGFLHSG TAKSVTCTYS PALNKLFCQL AKTCPVQLWV SSPPPPGTRV RAMAIYKKSE YMTEVVRRCP HHERCSDYSD GLAPPQHLIR VEGNLRAEYL DDRNTFRHSV VVPYEPPEVG SDCTTIHYNF MCNSSCMGGM NRRPILTIIT LEDSNGNLLG RNSFEVRVCA CPGRDRRTEE ENFHKKGQSC PELPTGSAKR ALPTGTSSSP PQKKKPLDGE YFTLQIRGRE RFEMFRELNE ALELKDAQAG KEPGESRAHS SHLKSKKGQS PSRHKKLMFK REGPDSD
Expression Region 1-387
Protein Description full length protein
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Still Have Questions? Leave a Message or Start an on-line Chat

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.