Recombinant Guinea pig Cellular tumor antigen p53(TP53)

Code CSB-YP892992GU
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Source Yeast
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Code CSB-EP892992GU
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Source E.coli
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Code CSB-EP892992GU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP892992GU
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Source Baculovirus
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Code CSB-MP892992GU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names TP53
Uniprot No. Q9WUR6
Alternative Names TP53Cellular tumor antigen p53; Tumor suppressor p53
Species Cavia porcellus (Guinea pig)
Expression Region 1-391
Target Protein Sequence MEEPHSDLSI EPPLSQETFS DLWKLLPENN VLSDSLSPPM DHLLLSPEEV ASWLGENPDG DGHVSAAPVS EAPTSAGPAL VAPAPATSWP LSSSVPSHKP YRGSYGFEVH FLKSGTAKSV TCTYSPGLNK LFCQLAKTCP VQVWVESPPP PGTRVRALAI YKKSQHMTEV VRRCPHHERC SDSDGLAPPQ HLIRVEGNLH AEYVDDRTTF RHSVVVPYEP PEVGSDCTTI HYNYMCNSSC MGGMNRRPIL TIITLEDSSG KLLGRDSFEV RVCACPGRDR RTEEENFRKK GGLCPEPTPG NIKRALPTST SSSPQPKKKP LDAEYFTLKI RGRKNFEILR EINEALEFKD AQTEKEPGES RPHSSYPKSK KGQSTSCHKK LMFKREGLDS D
Protein Length full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2.
Gene References into Functions
  1. P53 may play an important role in impulse noise induced-hair cell apoptosis. PMID: 21429338
Involvement in disease p53 is found in increased amounts in a wide variety of transformed cells. p53 is frequently mutated or inactivated in many types of cancer.
Subcellular Location Cytoplasm, Nucleus, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix
Protein Families P53 family
Database Links

STRING: 10141.ENSCPOP00000012841

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