Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1), partial

1. PLCbeta1 is a candidate signature gene for proneural subtype high-grade glioma. PMID: 26614510
2. Dysregulation of primary PLC signaling is linked to several brain disorders including epilepsy, schizophrenia, bipolar disorder, Huntington's disease, depression and Alzheimer's disease. (Review) PMID: 26639088
3. Phospholipase C beta connects G protein signaling with RNA interference. (Review) PMID: 26746047
4. The role of PLCb1 nuclear isoform is being analyzed in relation to the cell cycle regulation, the cell differentiation, and different physiopathological pathways focusing on the importance of the nuclear localization from both molecular and clinical point of view. (Review) PMID: 28106288
5. PI-PLCbeta1 is a modulator of hematopoiesis. [review] PMID: 26525203
6. Polymorphism of the PLCB4/B1 genes might be involved in the coronary artery aneurysm pathogenesis of Kawasaki disease. PMID: 26434682
7. Reduction in plasma membrane PI(4,5)P2 abundance by PTPRN2 and PLCbeta1 releases the PI(4,5)P2-binding protein cofilin from its inactive membrane-associated state into the cytoplasm where it mediates actin turnover dynamics. PMID: 26620550
8. The rs6108160 polymorphism in the PLCB1 gene reached statistical significance after antidepressant drug use. PMID: 25649181
9. results show that PI-PLCbeta1 quantification in MDS predicts the response to azacitidine and is associated with an increased myeloid differentiation. PMID: 25977289
10. one specific Egr-1 binding site was identified at nt-451/-419 and PLCB1 promoter activity was increased more than 5-fold PMID: 25192965
11. Cholesterol regulates HERG K+ channel activation by increasing phospholipase C beta1 expression PMID: 23793622
12. Our data indicate that the amplification of PLCb1a expression, following treatment with kinamycin F, confers a real advantage to K562 cells viability and protects cells themselves from apoptosis. PMID: 25160985
13. PLCB1 is now reported in a number of different EIEE (early infantile epileptic encephalopathy) phenotypes and our report provides further evidence for phenotypic pleiotropy encountered in early infantile epilepsy syndromes. PMID: 24684524
14. Phospholipase C-beta1 and beta4 contribute to non-genetic cell-to-cell variability in histamine-induced calcium signals in HeLa cells. PMID: 24475116
15. Novel variations in PLCB1 do not allow prediction of functional phenotypes that might explain, at least in part, the symptoms of malignant migrating partial seizures of infancy (MMPSI). PMID: 24315024
16. PLC-beta1 and DAGL-alpha are detected in discrete brain regions, with a marked predominance of pyramidal morphologies of positive cortical cells.[review] PMID: 24076015
17. nuclear PI-PLCb1 signalling is involved in diseases showing an altered myogenic differentiation and affecting the hematopoietic system.[review] PMID: 24296032
18. Interaction between PLCbeta1 and TRAX affect the function of TRAX as part of the machinery involved in RNA interference. [review] PMID: 23916604
19. PLCbeta1-linked signaling pathways may be involved in the neural system in schizophrenia. [review] PMID: 24035496
20. The selectivity of PLCbeta toward certain genes lies in the rate at which the RNA is hydrolyzed by C3PO. PMID: 24338081
21. PLCbeta1 positively targets cyclin D3, likely through a PKCalpha mediatedpathway, and that, as a downstream effect of its activity, K562 cells undergo to an accumulation in the S phase of the cell cycle, leading to a decrease of cell proliferation. PMID: 23656785
22. a concerted gp120-mediated signaling involving both PC- and PI-specific phospholipase C beta1 is required for the expression of CCL2 in macrophages PMID: 23555755
23. A peptide that mimics part of the alpha-synuclein binding site to PLCbeta prevents aggregation. PLCbeta1 can reduce cell damage under oxidative stress and offers a potential site that might be exploited to prevent alpha-synuclein aggregation. PMID: 23659438
24. Nuclear signaling elicited by phospholipase C beta1 plays an important role in the control of the balance between cell cycle progression and apoptosis in myelodysplastic syndrome cells. (Review) PMID: 23058275
25. PLCbeta1 is enriched at the plasma membrane. PMID: 23006664
26. Data show a novel role of phospholipase Cbeta1 (PLCbeta1) in gene regulation through translin-associated factor X (TRAX) association. PMID: 22889834
27. existence of a susceptibility locus on the short arm of chromosome 20 moved us to analyse PLCB1, the gene codifying for PI-PLC beta1 enzyme, which maps on 20p12 PMID: 22507702
28. case report - homozygous deletion associated with malignant migrating partial seizures in infancy PMID: 22690784
29. PLCbeta1 expression is a key player in myoblast differentiation, functioning as a positive regulator in the correction of delayed differentiation of skeletal muscle in myotonic dystrophy myoblasts PMID: 22459146
30. Alpha-synuclein protects the integrity of PLCbeta1 and its ability to be activated by Galpha q, which may in turn impact calcium signaling. PMID: 22286107
31. PI-PLCbeta1 gene amplification seems to be correlated to clinicopathological parameters. PMID: 22076473
32. For the first time it is shown that SHP-2 and PLCbeta1 are present as a preformed complex. Complex PLCbeta1 is tyr-phosphorylated basally. Ang II increased SHP-2-PLCbeta1 complexes and caused complex associated PLCbeta1 tyr-phosphorylation to decline. PMID: 21663700
33. These studies suggest that Protein kinase C phosphorylation regulates the level of PLCB1 cytosolic and nuclear activity by regulating its cellular compartmentalization. PMID: 21338571
34. data confirm that phospholipase C beta 1 transcript levels are decreased in the dorsolateral prefrontal cortex from subjects with schizophrenia. However, the changes in levels of mRNA do not translate into a change at the level of protein. PMID: 21091263
35. These findings suggest that PLC/CAMK IV-NF-kappaB is involved in RAGE mediated signaling pathway in human endothelial cells. PMID: 20171262
36. An extracellular PI-PLC enzyme activity that may be acutely involved in the regulation of PtdIns levels in lung surfactant, was identified. PMID: 19491339
37. detailed analysis of the human PLC beta1 gene showing the existence of alternative splicing; complete determination of the exon/intron structure of the gene spanning 250 kb of DNA PMID: 12213492
38. PLC beta 3 and PLC beta 1 bind to calmodulin PMID: 12821674
39. The myelodysplastic syndrome patients, bearing the deletion, rapidly evolved to acute myeloid leukemia. PMID: 15085153
40. This review summarizes current knowledge about nuclear PI-PLC-beta 1, its localization, activity changes during cell cycle phases, and possible involvement in the progression of myelodisplastic syndrome to acute myeloid leukemia. PMID: 16136505
41. alternative pathway operates in the absence of Lck-dependent tyrosine-phosphorylation events and was initiated by the T cell receptor-dependent activation of raft-enriched heterotrimeric Galpha11 proteins PMID: 16860758
42. These results support the model that activation of selected PLC isoforms at the cleavage furrow controls progression of cytokinesis through regulation of PIP2 levels PMID: 17041247
43. New data in this review hints at the fact that the imbalance of nuclear versus cytoplasmic phosphatidylinositol-phospholipase C beta 1 signaling could affect the cell cycle progression of hematopoietic cells. PMID: 17335878
44. These results demonstrate that two waves of nuclear PI-PLCbeta(1b) activity occur in serum-stimulated cells during G(1) phase of the cell cycle and that the later increase in the PLC activity is equally important for the progression into the S phase. PMID: 17363325
45. PC-PLC and ROS were involved in chicken blastodisc differentiation to vascular endothelial cells. PC-PLC was an important factor in the blastodisc cell survival and differentiation, and it might perform its function associated with ROS. PMID: 17393430
46. Spontaneous calcium oscillations and nuclear translocation of PLC-beta1 may reflect some degree of oocyte maturity. PMID: 17620288
47. PC-PLC activation through CCR5 is specifically induced by gp120, since triggering CCR5 through its natural ligand CCL4 (MIP-1beta) does not affect PC-PLC cellular distribution and enzymatic activity, as well as CCL2 secretion PMID: 18203956
48. Ins(1,4,5)P(3) and IP(3)-receptor (type 2) regulate PLCbeta1 and thereby maintain levels of Ins(1,4,5)P(3), which implies some functional significance for Ins(1,4,5)P(3) in the heart PMID: 18692062
49. PLCb1 localization is regulated by its own substrate, phosphatidylinositol (4,5)-bisphosphate. PMID: 18957514
50. The association between the presence of phosphoinositide-phospholipase C beta1 (PI-PLCbeta1) mono-allelic deletion with the clinical outcome of myelodysplastic syndromes (MDS) patients was evaluated. PMID: 19114693

Show More

Hide All

HGNC: 15917

OMIM: 607120

KEGG: hsa:23236

STRING: 9606.ENSP00000338185

UniGene: Hs.431173