Recombinant Human Atrial natriuretic peptide receptor 1(NPR1),partial

In Stock
Code CSB-EP016023HU
Product Type Recombinant Protein
Size US$1726Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P16066
Relevance Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP016023HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NPR1.
  • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP016023HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) NPR1.
Storage Buffer Tris-based buffer,50% glycerol
Alias Atrial natriuretic peptide receptor type A ;ANP-A ;ANPR-A ;NPR-AGuanylate cyclase A ;GC-A
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLE
Research Area Cardiovascular
Source E.coli
Gene Names NPR1
Expression Region 33-473aa
Tag Info N-terminal 6xHis-SUMO-tagged
Mol. Weight 64.9kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Adenylyl cyclase class-4/guanylyl cyclase family
Database Links

HGNC: 7943

OMIM: 108960

KEGG: hsa:4881

STRING: 9606.ENSP00000357669

UniGene: Hs.490330

Pathway cAMP signaling pathway
Vascular smooth muscle contraction
cGMP-PKG signaling pathway

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