Recombinant Human B-cell receptor CD22(CD22),partial

Code CSB-MP004900HU
Product Type Recombinant Protein
Size US$1109
Uniprot No. P20273
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Tris-based buffer,50% glycerol
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Research Area Immunology
Source Mammalian cell
Gene Names CD22
Protein Names Recommended name: B-cell receptor CD22 Alternative name(s): B-lymphocyte cell adhesion molecule Short name= BL-CAM Sialic acid-binding Ig-like lectin 2 Short name= Siglec-2 T-cell surface antigen Leu-14 CD_antigen= CD2
Expression Region 20-687aa
Tag Info C-terminal 6xHis-tagged
Mol. Weight 79.1 kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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Function Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Subcellular Location Cell membrane, Single-pass type I membrane protein
Protein Families Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Tissue Specificity B-lymphocytes.
Database Links

HGNC: 1643

OMIM: 107266

KEGG: hsa:933

STRING: 9606.ENSP00000085219

UniGene: Hs.579691

Pathway B cell receptor signaling pathway
Hematopoietic cell lineage

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