Purity
Greater than 90% as determined by SDS-PAGE.
Alternative Names
300 kDa mannose 6 phosphate receptor; 300 kDa mannose 6-phosphate receptor; Cation independent mannose 6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CD222 antigen; CI Man 6 P receptor; CI Man-6-P receptor; CI MPR; CI-M6PR; CI-MPR; CIMPR; IGF 2 receptor; IGF 2R; IGF II receptor; IGF-II receptor; IGF2 receptor; Igf2r; Insulin like growth factor 2 receptor; Insulin like growth factor II receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P R; M6P/IGF2 receptor; M6P/IGF2R; M6PR; mannose 6 phosphate receptor; mannose 6 phosphate receptor, cation independent; MPR 300; MPR300; MPRI; MPRI_HUMAN
Species
Homo sapiens (Human)
Expression Region
2328-2491aa
Target Protein Sequence
KKERRETVISKLTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI
Note: The complete sequence including tag
sequence, target protein sequence and linker sequence could be provided upon request.
Tag Info
N-terminal GST-tagged
Form
Liquid or Lyophilized powder
Note: We will preferentially ship the format that
we have in stock, however, if you have any special requirement for the format, please remark your
requirement when placing the order, we will prepare according to your demand.
Buffer
Tris-based buffer,50% glycerol
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw
cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature
and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized
form is 12 months at -20°C/-80°C.
Lead Time
Basically, we can dispatch the products out in 1-3
working days after receiving your orders. Delivery time may differ from different purchasing way or
location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with
normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance
and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.
Description
The expression vector recombined with the recombinant DNA was transformed into the E.coli for expression. The recombinant DNA resulted from the fusion of the gene coding for the 2328-2491aa of the human IGF2R protein and the N-terminal GST tag gene. The product was purified and isolated to get the recombinant human IGF2R protein with N-terminal GST tag. The purity of this recombinant IGF2R protein reaches up to 90%. Under SDS-PAGE condition, this recombinant IGF2R protein showed a band with a molecular weight of about 45 kDa on the gel.
IGF2R is a gene encoding a protein named Insulin-like growth factor 2 receptor (IGF2R, also called the cation-independent mannose-6-phosphate receptor. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. IGF2R protein is a receptor for both insulin-like growth factor 2 (IGF2) and mannose 6-phosphate. This protein is a multifunctional protein receptor that binds IGF2 at the cell surface and mannose-6-phosphate (M6P)-tagged proteins in the trans-Golgi network. A study has revealed an unappreciated biological function of the IGF2-IGF2R axis in regulating the fate of maturing macrophages to acquire either a pro- or anti-inflammatory phenotype. It suggests that targeting IGF2R activation can potentially be used to reduce inflammation in the treatment of inflammatory disease.
