Recombinant Human Cystathionine beta-synthase (CBS), partial

The recombinant Human CBS protein is encoded by the gene of CBS (1-413aa). The gene of CBS was cloned in a system (E.coli) that supported the expression of CBS. Modification of CBS by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 6xHis-SUMO tag in the production. The purity is 90% determined by SDS-PAGE.

CBS is a protein coding gene that encodes Cystathionine beta-synthase. According to some studies, CBS may have the following features.
Commonly used pharmacological inhibitors are selective for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE). The CBS domain forms an energy sensor module, and its binding to adenosine ligands is disrupted by disease mutations. Anatomical differences between CBS-cortical basal degeneration and CBS-Alzheimer's disease. Cysteine β synthase (CBS) contributes to the progression and drug resistance of advanced ovarian cancer. The expression of cystathionine beta synthase (CBS) gene during mouse development and its immunolocalization in the adult brain. The function and structure of the CBS domain from the CLC chloride channel are preserved. The overproduction of H2S produced by CBS inhibits mitochondrial complex IV and inhibits the oxidative phosphorylation of Down syndrome.