Recombinant Human Endothelial cell-specific molecule 1 (ESM1)

1. Results show that aerum ESM-1 levels were significantly higher in the idiopathic sudden sensorineural hearing loss group than the control group which may confirm endothelial dysfunction involvement. PMID: 30370871
2. suggest that measurement of endocan level may help clinicians to predict the development of coronary collateral circulation in patients with stable coronary artery disease PMID: 28393589
3. suggest that serum ESM-1 level may be a novel endothelial dysfunction biomarker PMID: 26927690
4. Plasma ESM-1 levels are decreased during pregnancy and increased in early- and late-onset preeclampsia. The source of ESM-1 is probably not the placenta, but most likely maternal endothelial cells. PMID: 29674200
5. Serial endocan concentration meets the major requirements for predicting outcome in patients with severe sepsis. An assay of endocan concentration may be a good prognostic biomarker in the clinic for severe sepsis. PMID: 29750963
6. The cutoff serum level of endocan predicting AD was >288.94 ng/mL in receiver operating characteristic curve analysis PMID: 29393258
7. A strong negative correlation was found between serum endocan levels and peak systolic velocity in men with severe erectile dysfunction. PMID: 29057489
8. Results show the endocan level in peripheral blood significantly elevated in patients newly diagnosed with multiple myeloma (MM), and associated with myeloma-specific clinical parameters. PMID: 30194153
9. The correlation between the secretion of endocan and that of IL-6 by endothelial cells suggests that endocan can be used as a predictive marker of inflammation for the quality assessment of transfusion grade PLTs PMID: 29238987
10. Serum ESM-1 levels correlate with stress hyperglycemia in patients with STEMI and are associated with short-term prognosis. PMID: 26685180
11. Endocan could be a common predictor of the endothelium-dependent inflammatory processes, rather than related with specific risk factors in coronary artery disease and microvascular angina. PMID: 26744512
12. Endocan is an inflammatory marker released by the endothelium and is associated with endothelial dysfunction and atherosclerosis in patients with systemic lupus erythematosus. PMID: 26614790
13. Endocan levels are higher in patients with large-artery atherosclerotic stroke and can help in predicting the short-term unfavourable outcome. PMID: 29287901
14. elevated expression on epidermal keratinocytes and dermal endothelial cells in lesional skin of atopic dermatitis; decreased expression in atopic dermatitis sera PMID: 28714079
15. Plasma ESM-1 is a novel biomarker for predicting the T status in OSCC patients. PMID: 29104463
16. ESM1 expression correlates with Gleason grade/score and with androgen receptor expression in prostate carcinoma tissue, so ESM1 should also be considered as a biomarker for diagnosis of prostate cancer. PMID: 29104483
17. Demonstrate an increased Endocan serum level in NAFLD patients, higher in those with type 2 diabetes mellitus and/or NASH because of an endothelial dysfunction in these pathologies. PMID: 28922438
18. Studied serum endocan levels in endometrial and ovarian cancer. Serum endocan levels were significantly higher in the entire patient group than in the controls. PMID: 27734523
19. This study showed that ESM-1 level in pleural effusion could be a potential diagnostic and prognostic marker in NSCLC patients with MPE. PMID: 28514746
20. Severe erectile dysfunction was associated with higher serum endocan levels than less severe erectile dysfunction or healthy controls. PMID: 28424502
21. Serum endocan levels >/= 2.05 ng/ml had a sensitivity of 76.1% and specificity of 85% for the diagnosis of bacterial infection in decompensated cirrhotic patients. The endocan measured at admission is a good clinical parameter predicting the occurrence of infection in these patients. Elevated endocan may reflect the degree of endothelial cell injury by a systemic inflammatory response. PMID: 28614777
22. study showed that higher endocan levels were significantly and independently related to the presence of slow coronary flow. PMID: 26607436
23. The results suggest that endocan may have a role in the pathogenesis of pterygium. PMID: 28410547
24. Endocan expression is increased in the human placenta from obese women with gestational diabetes, and in response to pro-inflammatory stimuli. Loss-of-function studies in villous trophoblast cells and HUVECs revealed that endocan is not directly involved in the genesis or in the expression of pro-inflammatory cytokines induced by LPS or IL-1beta. PMID: 27871471
25. Systemic inflammation may be responsible for the rise in endocan levels following cardiopulmonary bypass. PMID: 26999704
26. Endocan expression was correlated with poor clinical outcomes in patients with Pancreatic Neuroendocrine Tumors . The results indicated that endocan expression may be a reliable marker for predicting tumor recurrence in patients with PNETs. PMID: 29019897
27. glomerular-derived Esm-1 as a potential non-invasive biomarker of diabetic nephropathy PMID: 28934365
28. Physical activity increases circulating endocan level. PMID: 28056805
29. These findings provide the first evidence that the imbalance of MMP-9/TIMP-1, is one of the regulation mechanisms by which ESM1 promotes tumorigenicity and metastasis of prostate cancer cells. PMID: 28108731
30. These results are consistent with the view that endocan measured in ICU patients is intact, stable, and accurate. Then, the low endocan level observed in ICU patients who developed acute respiratory distress syndrome is likely to be reliable. PMID: 28427918
31. Dopamine agonist resistance-related ESM1 promotes the angiogenesis and tumor cells growth of prolactinomas, suggesting that ESM1 may be a novel therapeutic target for prolactinomas. PMID: 26662185
32. These results suggest human cytomegalovirus infection leads to glioma progression through an upregulation of endocan and the secretion of inflammatory cytokines. PMID: 27474433
33. Endocan-expressing microvessel density significantly correlates with the expression of VEGF and VEGFR2 and is a valuable prognostic factor for survival in human gastric cancer. PMID: 27340359
34. Circulating P-selectin levels were closely associated with endocan levels in obese children and adolescents with non-alcoholic fatty liver disease. PMID: 28318371
35. this study shows that endocan may play an important role in the development of connective tissue disease related pulmonary arterial hypertension PMID: 27912147
36. The distribution of Gleason score and biochemical failure rate were significantly higher in patients with serum endocan >/=1.8 ng/mL (p = 0.031 and p = 0.047). PMID: 27470607
37. endocan plays an anti-carcinogenic role in gastric cancer development and progression and might serve as a prognostic biomarker as well as a potential therapeutic target for gastric cancer. PMID: 27644250
38. High ESM1 expression is associated with Meningiomas and Gliomas. PMID: 27528791
39. Serum and urinary endocan concentrations are significantly elevated in patients with bladder cancer. PMID: 26748103
40. Subclinical hypothyroidism is associated with increased levels of serum endocan, dimethylarginine, and TGF-beta, which are new markers for endothelial dysfunction. PMID: 27993872
41. The levels of ESM1, CLDN5, IL-1beta, IL-6, and TNF-alpha were significantly higher in the migraine attack group than in the control group PMID: 27010153
42. Results found that serum endocan levels were significantly lower in Alzheimer's disease (AD) patients with depression than in AD patients without depression or healthy controls suggesting that serum endocan levels might be associated with depression in AD. PMID: 26924874
43. serum levels of endocan, a new biomarker of endothelial dysfunction, increase in obstructive sleep apnea subjects. PMID: 26808694
44. Endocan may play a role in the progression of pregnancy and has a potential to be a new marker for the detection of pre-eclampsia PMID: 26823798
45. Serum endocan concentrations were significantly elevated in women with pre-eclampsia versus normotensive controls, and concentrations seem to be associated with the severity of the disease. PMID: 26418319
46. Suggest that serum endocan concentrations are elevated in patients with type 2 diabetes and decrease following anti-hyperglycemic treatment. PMID: 25969567
47. Median maternal plasma endocan concentrations were higher in preeclampsia and lower in acute pyelonephritis with bacteremia than in uncomplicated pregnancy. PMID: 25211383
48. Elevated endocan levels were more strongly associated with disease severity among Johnson Syndrome, Toxic Epidermal Necrolysis subjects than among less severe allergic reactions with skin involvement. PMID: 25394955
49. Detection of ESM-1 levels in the serum may serve as a tumor biomarker for assessing prognosis in colorectal cancer. PMID: 26125749
50. Serum endocan level is independently correlated with the presence and severity of coronary artery disease in hypertension patients. PMID: 26200037

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HGNC: 3466

OMIM: 601521

KEGG: hsa:11082

STRING: 9606.ENSP00000370812

UniGene: Hs.129944